Výsledky vyhledávání - "Mauricio E. Di Ianni"

Molecular Topology and Other Promiscuity Determinants as Predictors of Therapeutic Class - A Theoretical Framework to Guide Drug Repositioning?

Autor: Mauricio E. Di Ianni, Alan Talevi, María Esperanza Ruiz, Lucas Nicolás Alberca, Juan Francisco Morales, Sara Chuguransky

Publikováno v: Current Topics in Medicinal Chemistry. 18:1110-1122

Much interest has been paid in the last decade on molecular predictors of promiscuity, including molecular weight, log P, molecular complexity, acidity constant and molecular topology, with correlations between promiscuity and those descriptors seemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dd8696135b335d8e73ebe80c3f4133
https://doi.org/10.2174/1568026618666180801091642

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New anticonvulsant candidates prevent P-glycoprotein (P-gp) overexpression in a pharmacoresistant seizure model in mice

Autor: Andrea Enrique, Elena Girardi, Luisa Rocha, Mauricio E. Di Ianni, María Guadalupe Valle-Dorado, Alan Talevi, Alberto Lazarowski, Juan José López Costa, Sofía Goicoechea

Publikováno v: Epilepsybehavior : EB. 121

Despite the approval of a considerable number of last generation antiepileptic drugs (AEDs) (only in the last decade, six drugs have gained Food and Drug Administration approval), the global figures of seizure control have seemingly not improved, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41eea1deb1a5690416a119f92e0d78f
https://pubmed.ncbi.nlm.nih.gov/31420290

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The application of molecular topology for ulcerative colitis drug discovery

Autor: Carolina Leticia Bellera, Alan Talevi, Mauricio E. Di Ianni

Publikováno v: Expert opinion on drug discovery. 13(1)

Introduction: Although the therapeutic arsenal against ulcerative colitis has greatly expanded (including the revolutionary advent of biologics), there remain patients who are refractory to current medications while the safety of the available therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcadafc3b3e11973f559a370eac9301
https://pubmed.ncbi.nlm.nih.gov/29088918

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Interaction of Solid Lipid Nanoparticles and Specific Proteins of the Corona Studied by Surface Plasmon Resonance

Autor: Guillermo R. Castro, German Abel Islan, Cecilia Yamil Chain, María Elena Vela, Alan Talevi, Mauricio E. Di Ianni

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Journal of Nanomaterials, Vol 2017 (2017)

The applications of pharmaceutical and medical nanosystems are among the most intensively investigated fields in nanotechnology. A relevant point to be considered in the design and development of nanovehicles intended for medical use is the formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a29e39ebf7dfb7508f3cb8925de6306
https://www.hindawi.com/journals/jnm/2017/6509184/

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Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy

Autor: Andrea Enrique, Pablo Hernán Palestro, Guido Pesce, Alan Talevi, Manuel Couyoupetrou, María Esperanza Ruiz, Luis E. Bruno-Blanch, Luciana Gavernet, Melisa Edith Gantner, Mauricio E. Di Ianni

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

Despite the introduction of more than 15 third generation antiepileptic drugs to the market from 1990 to the moment, about one third of the epileptic patients still suffer from refractory to intractable epilepsy. Several hypotheses seek to explain th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b125d60b062e7122d2126747ec893a8
http://sedici.unlp.edu.ar/handle/10915/103425

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An Integrated Drug Development Approach Applying Topological Descriptors

Autor: Mauricio E. Di Ianni, Luis E. Bruno-Blanch, Pablo R. Duchowicz, Carolina Leticia Bellera, Eduardo A. Castro, Alan Talevi

Publikováno v: Current Computer Aided-Drug Design. 8:172-181

We describe the opportunities posed by computer-assisted drug design in the light of two aspects of the current drug discovery scenario: the decline of innovation due to high attrition rates at clinical stage of development and the combinatorial expl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891180f1928768ae2a4859bd9562cae8
https://doi.org/10.2174/157340912801619076

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Development of a highly specific ensemble of topological models for early identification of P-glycoprotein substrates

Autor: Alan Talevi, Eduardo A. Castro, Mauricio E. Di Ianni, Luis E. Bruno-Blanch

Publikováno v: Journal of Chemometrics. 25:313-322

P-glycoprotein (Pgp) is an ATP-dependent efflux transporter protein associated with multidrug resistance in several diseases such as cancer, epilepsy and AIDS. It is preferentially expressed in organs and tissues that function as a barrier (e.g. the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0dbadd089c612b5c5b165dd50d3cb2
https://doi.org/10.1002/cem.1376

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Computer-Aided Identification of Anticonvulsant Effect of Natural Nonnutritive Sweeteners Stevioside and Rebaudioside A

Autor: Mauricio E. Di Ianni, Andrea Enrique, María Elena del Valle, Luis E. Bruno-Blanch, Alan Talevi, Fiorella Gianina Bruno, María Adelaida Rosella

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6833f73b7fa509ecfbc577415dabb6f9
http://sedici.unlp.edu.ar/handle/10915/127131

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Systematic Comparison of the Performance of Different 2D and 3D Ligand-Based Virtual Screening Methodologies to Discover Anticonvulsant Drugs

Autor: Mauricio E. Di Ianni, Melisa Edith Gantner, Alan Talevi, Eduardo A. Castro, María Esperanza Ruiz, Luis E. Bruno-Blanch

Publikováno v: Combinatorial chemistryhigh throughput screening. 18(4)

Virtual screening encompasses a wide range of computational approaches aimed at the high-throughput, cost-efficient exploration of chemical libraries or databases to discover new bioactive compounds or novel medical indications of known drugs. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7948237da3ba96b951baf4da39ec0d
https://pubmed.ncbi.nlm.nih.gov/25747440

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