Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Mauricio Castellano"'
1
Akademický článek
Paternal methotrexate exposure affects sperm small RNA content and causes craniofacial defects in the offspring
Autor: Nagif Alata Jimenez, Mauricio Castellano, Emilio M. Santillan, Konstantinos Boulias, Agustín Boan, Luisa F. Arias Padilla, Juan I. Fernandino, Eric L. Greer, Juan P. Tosar, Luisa Cochella, Pablo H. Strobl-Mazzulla
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Anti-folate drugs, such as methotrexate, have been largely prohibited for pregnant women because of the teratogenic effect on their descendant. Here, the authors report a intergenerational mechanism by why paternal methotrexate exposure causes cranio
Externí odkaz: https://doaj.org/article/bdbbd06065c1491b804a9835209c28eb
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2
Akademický článek
Serum amyloid A is a positive acute phase protein in Russian sturgeon challenged with Aeromonas hydrophila
Autor: Mauricio Castellano, Valeria Silva-Álvarez, Marcio Aversa-Marnai, María Lamas-Bervejillo, Ignacio Quartiani, Alejandro Perretta, Andrea Villarino, Ana María Ferreira
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract The immune system of sturgeons, one of the most ancient and economically valuable fish worldwide, is poorly understood. The lack of molecular tools and data about infection biomarkers hinders the possibility to monitor sturgeon health during
Externí odkaz: https://doaj.org/article/1210cd24feae4cd1882d11a5f7f294ee
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3
Akademický článek
RI-SEC-seq: Comprehensive Profiling of Nonvesicular Extracellular RNAs with Different Stabilities
Autor: Juan Pablo Tosar, Fabiana Gámbaro, Mauricio Castellano, Alfonso Cayota
Publikováno v: Bio-Protocol, Vol 11, Iss 4 (2021)
Exosomes and other extracellular vesicles (EVs) are considered the main vehicles transporting RNAs in extracellular samples, including human bodily fluids. However, a major proportion of extracellular RNAs (exRNAs) do not copurify with EVs and remain
Externí odkaz: https://doaj.org/article/10517c7ef8384f38a95e7784e17c8d20
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4
A different transcriptional landscape sheds light on Russian sturgeon (Acipenser gueldenstaedtii) mechanisms to cope with bacterial infection and chronic heat stress
Autor: Alicia Costábile, Mauricio Castellano, Marcio Aversa-Marnai, Ignacio Quartiani, Daniel Conijeski, Alejandro Perretta, Andrea Villarino, Valeria Silva-Álvarez, Ana María Ferreira
Publikováno v: Fish & Shellfish Immunology. 128:505-522
Sturgeons are chondrostean fish of high economic value and critically endangered due to anthropogenic activities, which has led to sturgeon aquaculture development. Russian sturgeon (Acipenser gueldenstaedtii), the second most important species reare
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c559329d61b00920e9cf0f2dd0fd4fd
https://doi.org/10.1016/j.fsi.2022.08.022
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5
Different response of Acipenser gueldenstaedtii CRP/SAP and SAA to bacterial challenge and chronic thermal stress sheds light on the innate immune system of sturgeons
Autor: Marcio Aversa-Marnai, Mauricio Castellano, Ignacio Quartiani, Daniel Conijesky, Alejandro Perretta, Andrea Villarino, Valeria Silva-Álvarez, Ana María Ferreira
Publikováno v: Fish & Shellfish Immunology. 121:404-417
Sturgeons are chondrostean fish critically endangered due to anthropogenic loss and degradation of natural habitat and overfishing for meat and caviar production. Consequently, sturgeon aquaculture has extensively developed lately, being Russian stur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0279cbef7553442592a4ac29bd71ea7
https://doi.org/10.1016/j.fsi.2021.12.029
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6
Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids
Autor: Bruno Costa, Marco Li Calzi, Mauricio Castellano, Valentina Blanco, Ernesto Cuevasanta, Irene Litvan, Pavel Ivanov, Kenneth Witwer, Alfonso Cayota, Juan Pablo Tosar
Nonvesicular extracellular RNAs (nv-exRNAs) constitute the majority of the extracellular RNAome, but little is known about their stability, function and potential use as disease biomarkers. Herein, we measured the stability of several naked RNAs when
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95da8cc5b819abba966f02d26612f75c
https://doi.org/10.1101/2022.08.31.506125
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7
Paternal methotrexate exposure affects sperm small RNA content and causes craniofacial defects in the offspring
Autor: Nagif Alata Jimenez, Mauricio Castellano, Emilio Santillan, Konstantinos Boulias, Agustin Boan, Luisa Arias Padilla, Juan Fernandino, Eric Greer, Juan Tosar, Luisa Cochella, Pablo strobl-mazzulla
Folate is an essential vitamin for vertebrate embryo development. Methotrexate (MTX) is a folate antagonist that is widely prescribed for autoimmune diseases, blood and solid organ malignancies, and dermatologic diseases. Although it is highly contra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea3c69c540f78afb2ea941b862690655
https://doi.org/10.21203/rs.3.rs-1841878/v1
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8
Serum amyloid A is a positive acute phase protein in Russian sturgeon challenged with Aeromonas hydrophila
Autor: Marcio Aversa-Marnai, María Lamas-Bervejillo, Alejandro Perretta, Ana M. Ferreira, Ignacio Quartiani, Valeria Silva-Álvarez, Andrea Villarino, Mauricio Castellano
Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
COLIBRI
Universidad de la República
instacron:Universidad de la República
The immune system of sturgeons, one of the most ancient and economically valuable fish worldwide, is poorly understood. The lack of molecular tools and data about infection biomarkers hinders the possibility to monitor sturgeon health during farming
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0060c477b8295bc90d61a01b4c48d4
http://europepmc.org/articles/PMC7746741
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9
Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome
Autor: Bruno Costa, Fabiana Gámbaro, Pavel Ivanov, Mauricio Castellano, Alfonso Cayota, Marcelo Hill, Tania Possi, Alvaro Olivera, Yasutoshi Akiyama, Juan Pablo Tosar, Pablo Fagúndez, Mercedes Segovia
Publikováno v: COLIBRI
Universidad de la República
instacron:Universidad de la República
Nucleic Acids Research
Extracellular RNAs (exRNAs) are implicated in intercellular communication pathways and show promising use as disease biomarkers in noninvasive liquid biopsies. To date, most research has focused in RNAs encapsulated inside extracellular vesicles (EVs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e066f20d2716771533668df51038d1f8
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10
Russian sturgeon cultured in a subtropical climate shows weaken innate defences and a chronic stress response
Autor: Andrea Villarino, Valeria Silva-Álvarez, Verónica Mauris, Elena Fernández-López, Daniel Conijeski, Ana M. Ferreira, Mauricio Castellano
Publikováno v: Fishshellfish immunology. 68
Russian sturgeon (Acipenser gueldenstaedtii) has been successfully farmed in Uruguay for the past ten years. However, during the Uruguayan summer fish endure high water temperatures and increased bacterial infections that threaten aquaculture. Our un
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c715392ca63b364ba59da7fd63214089
https://pubmed.ncbi.nlm.nih.gov/28743624
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