Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maurice S. Maidment"'
Autor:
Andrew Cooke, Alison Anderson, David K. Gemmell, D. Jonathan Bennett, Peter Vijn, Donald F.M. Stevenson, Hardy Sundaram, Maurice S. Maidment, Kirsteen Buchanan, Alan Byford, Petula McPhail, Niall M. Hamilton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1971-1975
A number of water soluble bis-amino-2,6-dimethoxyphenyl ester derivatives were found to exhibit improved anaesthetic activity in mice relative to propofol 1. Of the analogues disclosed, 44 was further profiled in rodents and found to be a superior ag
Autor:
Valerie May, Jeremy J. Lambert, David K. Gemmell, Alison Anderson, Maurice S. Maidment, Alexander C. Campbell, David R. Hill, Donald F. M. Stevenson, Claire Hill-Venning, David Rees, Richard J. Marshall, Andrew C. Boyd, Alan Byford, Hardy Sundaram, John A. Peters, Niall M. Hamilton
Publikováno v:
Journal of Medicinal Chemistry. 40:1668-1681
(3 alpha,5 alpha)-3-Hydroxypregnan-20-ones and (3 alpha,5 alpha)-3-hydroxypregnane-11,20-diones bearing a 2 beta-morpholinyl substituent were synthesized, and the utility of these steroids as anesthetic agents was evaluated through determination of t
Autor:
Petula McPhail, Andrew Cooke, Donald F.M. Stevenson, David K. Gemmell, Hardy Sundaram, Kirsteen Buchanan, Alison Anderson, Niall M. Hamilton, Maurice S. Maidment, Jonathan Bennett
Publikováno v:
ChemInform. 34
A novel series of alpha-amino-acid phenolic ester derivatives containing sulphide, sulphoxide, sulphone, ester and amide side chains were prepared and shown to display potent intravenous anaesthetic activity.
Autor:
Jeremy J. Lambert, McPhail P, John A. Peters, Sansbury Fh, Muntoni A, Hutchinson Ej, Bennett Dj, Donald F. M. Stevenson, Maurice S. Maidment, Alison Anderson, Feilden H, Miller S, Ross McGuire, Cooke A, Delia Belelli, Buchanan Ki, Casula A, Sundaram H, Gemmell Dk, Hamilton Nm
Publikováno v:
Journal of medicinal chemistry. 44(22)
In the search for a novel water-soluble general anesthetic agent the activity of an alpha-amino acid phenolic ester lead, identified from patent literature, was markedly improved. In addition to improving in vivo activity in mice, good in vitro activ
Autor:
John K. Clark, Alison Anderson, Petula McPhail, Lee Fielding, Andrew C. Boyd, Maurice S. Maidment, Hardy Sundaram, Robert Taylor, Valerie May, Ross McGuire, Francis H. Sansbury, David K. Gemmell, Niall M. Hamilton
Publikováno v:
Journal of medicinal chemistry. 43(22)
Various cyclic ether and other 3 alpha-hydroxyandrostane derivatives bearing a conformationally constrained hydrogen-bonding moiety were prepared. Their anesthetic potency and their binding affinity for GABA(A) receptors, measured by intravenous admi
Autor:
Andrew Cooke, Alan Byford, Alison Anderson, Petula McPhail, Maurice S. Maidment, D. Jonathan Bennett, David K. Gemmell, Niall M. Hamilton, Hardy Sundaram, Donald F.M. Stevenson, Kirsteen Buchanan, Peter Vijn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2939
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1799-1804
The rearrangement of 9α,11α-epoxy-5α-pregnane-3β-20β-diyl diacetate (3) to 11-oxo-5α,9β-pregnane-3β,20β-diyl diacetate (4) and 11α-hydroxy-9β-methyl-19-norpregn-5(10)-ene-3β,20β-diyl diacetate (5) is reported. Treatment of the 5(10)-ene
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1936-1940
Preparation of the four isomeric 3,11-diamino-5α-pregnanes is reported. Three (3β,11α-, 3α,11α-, and 3α,11β-) were prepared from 5α-pregnane-11,20-dione obtained from 20-oxo-5α-pregnane-3β,11α-diyl diacetate. The fourth (3β,11β-) was pre
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1783-1789
Autor:
John H. Pick, Gilbert F. Woods, Maurice S. Maidment, Donald F. M. Stevenson, Alexander C. Campbell
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :163-171
17,17-Dimethyl-18-nor-5β-androsta-8,11,13-trien-3α-yl acetate (6) has been prepared from 9α,11α-epoxy-17α-methyl-5β-androstane-3α,17β-diol 3-acetate (5) in good yield. An attempt to repeat the aromatisation with the analogous 9α,11α-epoxy-5