Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Maurice L. Slevin"'
Autor:
Theresa Davis, Matthew T. Seymour, Maurice L. Slevin, Dimitri Papamichael, Vassili Aslanis, Kathryn Locke, Etienne Chatelut, Simon P. Joel, Fiona Richards
Publikováno v:
Clinical Pharmacology & Therapeutics. 76:45-54
Objective Our objective was to investigate the influence of oxaliplatin on the pharmacokinetics of 5-fluorouracil (5FU) administered in a bolus plus infusional regimen. Patients and methods All patients had advanced/metastatic colorectal cancer. In s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65332ee10c2b3d3c13ff3d3981e56437
https://doi.org/10.1016/j.clpt.2004.03.008
https://doi.org/10.1016/j.clpt.2004.03.008
Publikováno v:
Palliative Medicine. 17:185-190
Morphine, the recommended drug for the management of moderate to severe cancer pain, is metabolized predominantly to the glucuronides morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G). The quantitative clinical importance of these metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f5326fb61c505264c05af63e374e7e
https://doi.org/10.1191/0269216303pm658oa
https://doi.org/10.1191/0269216303pm658oa
Publikováno v:
British Journal of Cancer
Irinotecan, mitomycin and cisplatin all demonstrate activity in gastro-oesophageal cancers. This novel combination was administered to outpatients with previously untreated inoperable gastro-oesophageal or pancreatic cancer, in a 28-day cycle. A tota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101d08373c3efb35d9b61b750f27c2f0
https://doi.org/10.1038/sj.bjc.6600553
https://doi.org/10.1038/sj.bjc.6600553
Autor:
Michael S. Roberts, Maurice L. Slevin, Anna Gloyne, Stephen Beckwith, Simon P. Joel, Richard T. Penson
Publikováno v:
British Journal of Clinical Pharmacology. 53:347-354
Aims Morphine-6-glucuronide (M6G), one of the active metabolites of morphine, has attracted considerable interest as a potent opioid analgesic with an apparently superior therapeutic index. To date studies have used the intravenous route, which is ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::256f42ae6671cfe1457c85fdbed03f00
https://doi.org/10.1046/j.1365-2125.2002.01554.x
https://doi.org/10.1046/j.1365-2125.2002.01554.x
Publikováno v:
Journal of Pharmaceutical Sciences. 90:1810-1816
The toxicity of morphine-3-glucuronide (M3G) has been investigated in an open, uncontrolled, single-blinded, single dose study over a limited range of doses. Three cohorts each of three healthy volunteers received 7.5, 15, and 30 mg/70 kg intravenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b844ef64caa1f20c82c73061fba744
https://doi.org/10.1002/jps.1131
https://doi.org/10.1002/jps.1131
Publikováno v:
British Journal of Clinical Pharmacology. 49:207-214
Aims To investigate the pharmacokinetics of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) in healthy volunteers after the administration of morphine by subcutaneous bolus injection (s.c.b.) and subcutaneous infusion (s.c.i.)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08adca60b7c131678087bb3cd82d7520
https://doi.org/10.1046/j.1365-2125.2000.00141.x
https://doi.org/10.1046/j.1365-2125.2000.00141.x
Autor:
H. Cresswell, Demetris Papamichael, J. T. Dent, Maurice L. Slevin, G. Wilson, Matthew T. Seymour
Publikováno v:
Annals of Oncology. 10:1329-1333
Summary Background ECF (epirubicin, cisplatin, protracted venous fluorouracil) is superior to FAMTX in gastroesophageal cancer, but protracted fluorouracil adds to its morbidity and cost. In this dose-escalation pilot study, fluorouracil was replaced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763a50b077a58f967ce14144b6fc9410
https://doi.org/10.1023/a:1008329822726
https://doi.org/10.1023/a:1008329822726
Autor:
Markella Boudioni, Maurice L. Slevin, J King, Mary Boulton, E Wilson, Klim McPherson, J Mossman, Angela Jones
Publikováno v:
British Journal of Cancer
A retrospective comparison of cancer incidence data and, where relevant, population data with 16 955first-time users (patients, relatives and friends) of a national cancer information service (CancerBACUP) during the period April1995 to March 1996 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7e7e34bfeb5b0811f1e2640b59cc7c
http://europepmc.org/articles/PMC2362157
http://europepmc.org/articles/PMC2362157
Autor:
Maurice L. Slevin, Teresa Tate
Cancer is a major issue in the provision of health care. It is estimated that one in four people in developed countries are likely to develop it at some time. As longevity steadily increases, the incidence of malignant disease is expected to rise fur
Autor:
Stefan C. Grant, Graham A. Ross, Mark G. Kris, Hedy L. Kindler, Jacqueline B. Krebs, Vincent A. Miller, Ian E. Smith, Maurice L. Slevin
Publikováno v:
American Journal of Clinical Oncology. 21:438-441
Topotecan (9-dimethylaminoethyl-10-hydroxycamptothecin) is a topoisomerase I inhibitor. Twenty-six patients with stage IIIB or IV non-small-cell lung cancer (NSCLC) who had received no prior chemotherapy were treated in a multicenter study with topot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d602138a88dd1c795d2f8cff92af39
https://doi.org/10.1097/00000421-199810000-00003
https://doi.org/10.1097/00000421-199810000-00003