Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Maurice K.C. Ho"'
Publikováno v:
Xenobiotica. 42:1138-1150
7-Methoxy-6-(3-methoxy-benzyloxy)-2-methylisoquinolin-1(2H)-one (named as IS0042) is a newly identified melatoninergic agonist which exhibits selectivity to the type 2 melatonin receptor. Here, we examined the in vitro and in vivo pharmacokinetics pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1823d28287f65d1228fe704679bcb7f6
https://doi.org/10.3109/00498254.2012.691186
https://doi.org/10.3109/00498254.2012.691186
Publikováno v:
Cellular Signalling. 23:389-397
The recent identification of Gα(z) expression in C2C12 myoblasts and its demonstrated interaction with the transcription factor Eya2 inferred an unanticipated role of Gα(z) in muscle development. In the present study, endogenous Gα(z) mRNA and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e890b9fc86c904e8abc0c1b3b60a2c
https://doi.org/10.1016/j.cellsig.2010.10.009
https://doi.org/10.1016/j.cellsig.2010.10.009
Autor:
Andrew M.F. Liu, Yung Hou Wong, Rico K.H. Lo, Wendy W.S. Yeung, Maurice K.C. Ho, Maggie M. K. Lee, Yingchun Wang, Yan Su, Richard D. Ye
Publikováno v:
Cellular Signalling. 22:1448-1458
Many G protein-coupled receptors (GPCRs) are known to modulate cell growth and differentiation by stimulating the extracellular signal-regulated protein kinases (ERKs). In growth factor signaling, ERKs are typically stimulated through an elaborate ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891ffd1f6b14e20d5739ac7a28dda371
https://doi.org/10.1016/j.cellsig.2010.05.013
https://doi.org/10.1016/j.cellsig.2010.05.013
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2582-2585
A series of substituted N-[3-(3-methoxyphenyl)propyl] amides were synthesized and their binding affinities towards human melatonin MT1 and MT2 receptors were evaluated. It was discovered that a benzyloxyl substituent incorporated at C6 position of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ee659190257a8c8ff9c898fc9c3195
https://doi.org/10.1016/j.bmcl.2010.02.084
https://doi.org/10.1016/j.bmcl.2010.02.084
Autor:
Nancy Y. Ip, Fanny C.F. Ip, Jing Zhu, Haihong Pang, Maurice K.C. Ho, Stephanie Lee, Allison C. Chin, Yung Hou Wong, Calvin B. Harley, Yueqing Hu
Publikováno v:
Drug Metabolism and Pharmacokinetics. 25:477-486
Cycloastragenol (CAG) is the aglycone derivative of astragaloside IV which has recently been demonstrated to activate telomerase and represents a potential drug candidate for the treatment of degenerative diseases. In the present study, intestinal ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52edc7067896f2c1dedb3424f68e2f5a
https://doi.org/10.2133/dmpk.dmpk-10-rg-037
https://doi.org/10.2133/dmpk.dmpk-10-rg-037
Publikováno v:
Biochemical Journal. 380:361-369
A broad repertory of G-protein-coupled receptors shows effective coupling with the haematopoietic G16 protein. In the present study, individual residues along the C-terminal alpha5 helix of Galpha16 were examined for their contributions in defining r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92878012f0260da266a6decca961b4ad
https://doi.org/10.1042/bj20040231
https://doi.org/10.1042/bj20040231
Autor:
Anjali Hazari, Vicki L. Lowes, Jasmine H.P. Chan, Cecilia S.S. Wong, Maurice K.C. Ho, Yung Hou Wong
Publikováno v:
Cellular Signalling. 16:51-62
G16 can couple indiscriminately to a large number of G protein-coupled receptors (GPCRs), making it a prime candidate as a universal adaptor for GPCRs. In order to increase the promiscuity of Gα16, three chimeras incorporating increasing lengths of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::404fe6d8ebab7bbaeb7b4fde4a21362c
https://doi.org/10.1016/s0898-6568(03)00097-4
https://doi.org/10.1016/s0898-6568(03)00097-4
Gα16/z Chimeras Efficiently Link a Wide Range of G Protein–Coupled Receptors to Calcium Mobilization
Autor:
Jasmine H.P. Chan, Anson H.M. Pau, Andrew M.F. Liu, Yung Hou Wong, Maurice K.C. Ho, Cecilia S.S. Wong
Publikováno v:
SLAS Discovery. 8:39-49
G protein-coupled receptors (GPCRs) represent a class of important therapeutic targets for drug discovery. The integration of GPCRs into contemporary high-throughput functional assays is critically dependent on the presence of appropriate G proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77699781f72094b22612625e375769b4
https://doi.org/10.1177/1087057102239665
https://doi.org/10.1177/1087057102239665
Autor:
Yung Hou Wong, Maurice K.C. Ho
Publikováno v:
Journal of Neurochemistry. 68:2514-2522
The alpha subunit of Gz (alpha(z)) harbors two N-terminal serine residues (at positions 16 and 27) that serve as protein kinase C-mediated phosphorylation sites. The cognate residues in the alpha subunit of Gt1 provide binding surfaces for the beta1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f19524818fa34b7a20fe4af5c20f538
https://doi.org/10.1046/j.1471-4159.1997.68062514.x
https://doi.org/10.1046/j.1471-4159.1997.68062514.x
Publikováno v:
Neurosignals. 11:115-122
Combinations of two different types of opioid receptors - delta-, kappa-, mu-opioid receptors (DOR, KOR, and MOR) and opioid receptor-like receptor 1 (ORL(1)) - were co-expressed with the alpha subunit of G(16) in COS-7 cells, and the ability of vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18f38b8caa9c5c12c7a8a681ad755a3e
https://doi.org/10.1159/000058548
https://doi.org/10.1159/000058548