Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Maurice J. Sauer"'
Publikováno v:
Analytical Biochemistry. 436:36-44
Prions are proteins that can exist in two (or more) folding states, a normal or cellular form and a series of infectious or prion forms, which are prone to aggregate. The prion form can induce conversion of the cellular form and so transmit phenotypi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8294f12491b90b4eee050e2ad8786d
https://doi.org/10.1016/j.ab.2013.01.015
https://doi.org/10.1016/j.ab.2013.01.015
Publikováno v:
Nutrition and Cancer. 63:300-305
The principal objectives of this study were to evaluate whether exposure of rats to low doses of isothiocyanates modulates the overall metabolism of heterocyclic amine 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ), as exemplified by urinary mutagenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27df59887e92443b502293ee359ce67
https://doi.org/10.1080/01635581.2011.530735
https://doi.org/10.1080/01635581.2011.530735
Publikováno v:
Cancer Letters. 284:15-20
The plasma pharmacokinetic characteristics of the chemopreventive isothiocyanate sulforaphane were determined in six human volunteers following single and repeated intake of raw broccoli. Initially, an analytical method utilising LC-MS/MS, capable of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0473f066acdff44bc79a2c65c0ccc07f
https://doi.org/10.1016/j.canlet.2009.04.004
https://doi.org/10.1016/j.canlet.2009.04.004
Publikováno v:
Journal of Mass Spectrometry. 44:384-396
New forms of transmissible spongiform encephalopathy (TSE) continue to be identified, and consequently sensitive differential diagnosis is increasingly important both for the management of disease in humans and livestock and in providing confidence i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88350c9de9148725dc7e71963497d4ba
https://doi.org/10.1002/jms.1516
https://doi.org/10.1002/jms.1516
Publikováno v:
Chemico-Biological Interactions. 177:115-120
The objective of this study was to evaluate the potential of the structurally related aliphatic isothiocyanates erucin and sulforaphane to modulate the pulmonary carcinogen-metabolising enzyme systems in rat lung, a target organ of their chemoprevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f299fbc3f15a45e3cc8ce6559a690f3
https://doi.org/10.1016/j.cbi.2008.08.015
https://doi.org/10.1016/j.cbi.2008.08.015
Publikováno v:
Journal of Agricultural and Food Chemistry. 56:7866-7871
Administration of dietary doses of the isothiocyanate erucin had no effect on rat hepatic cytochrome P450 activity or protein levels, but at higher doses a rise in CYP1A/B1 protein levels was evident. In lung, treatment with erucin, as well as sulfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27328f03fdb16ea5ce7ebf8af0e721a2
https://doi.org/10.1021/jf801456h
https://doi.org/10.1021/jf801456h
Autor:
Adriana Gielbert, Natalya Hanlon, Costas Ioannides, L. J. King, Maurice J. Sauer, Nick G. Coldham, Nikolai Kuhnert
Publikováno v:
British Journal of Nutrition. 99:559-564
Sulforaphane is a naturally occurring isothiocyanate with promising chemopreventive activity. An analytical method, utilising liquid chromatography-MS/MS, which allows the determination of sulforaphane in small volumes of rat plasma following exposur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ff821236500e449268244e4b63361c
https://doi.org/10.1017/s0007114507824093
https://doi.org/10.1017/s0007114507824093
Publikováno v:
Biomarkers. 13:393-412
Assessment of the different conformational states of the abnormal prion protein (PrP(Sc)) in the CNS provides an established basis for distinguishing transmissible spongiform encephalopathy (TSE) strains. PrP(Sc) conformers are variably resistant to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab402fe6990d3d5298931e7a07f157b
https://doi.org/10.1080/13547500801903719
https://doi.org/10.1080/13547500801903719
Autor:
Costas Ioannides, Peter Kentish, Victoria Yoxall, Nick G. Coldham, Maurice J. Sauer, Nikolai Kuhnert
Publikováno v:
International Journal of Cancer. 117:356-362
The principal objectives of our study were to ascertain whether sulforaphane, at dietary levels of intake, modulates rat hepatic cytochrome P450 and phase II enzyme systems and to evaluate the impact of such changes in the chemopreventive activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99771af579bde2a533c305a8aae6aa8b
https://doi.org/10.1002/ijc.21191
https://doi.org/10.1002/ijc.21191
Autor:
Susila Sivapathasundaram, Laurence Howells, Costas Ioannides, Nick G. Coldham, Paraskevi Magnisali, Maurice J. Sauer
Publikováno v:
Toxicology. 187:49-65
Cytochrome P450 expression in cervine liver was investigated using chemical probes and Western blot analysis, and compared with the rat. Deer liver, when compared with rat liver, was characterised by high ethoxyresorufin O -deethylase, coumarin 7-hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a3ce243062cb783ec1fd08a15d913a
https://doi.org/10.1016/s0300-483x(03)00026-x
https://doi.org/10.1016/s0300-483x(03)00026-x