Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Maurice Green"'
Publikováno v:
Virology. 499:178-184
The adenovirus E1A 243R oncoprotein targets TRRAP, a scaffold protein that assembles histone acetyltransferase (HAT) complexes, such as the NuA4/Tip60 complex which mediates transcriptional activity of the proto-oncogene MYC and helps determine the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988b5e17ccd86dfe426794e4281bded3
https://doi.org/10.1016/j.virol.2016.09.005
https://doi.org/10.1016/j.virol.2016.09.005
Publikováno v:
Genes & Cancer
Human cancers frequently arise from increased expression of proto-oncogenes, such as MYC and HER2. Understanding the cellular pathways regulating the transcription and expression of proto-oncogenes is important for targeted therapies for cancer treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cf079050c34c25873cf07b8ff807d5
https://doi.org/10.18632/genesandcancer.99
https://doi.org/10.18632/genesandcancer.99
Publikováno v:
Genes & Cancer
We recently reported that adenovirus E1A enhances MYC association with the NuA4/Tip60 histone acetyltransferase (HAT) complex to activate a panel of genes enriched for DNA replication and cell cycle. Genes from this panel are highly expressed in exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8628cbfe6e3a62c248032175b172606a
https://pubmed.ncbi.nlm.nih.gov/30108681
https://pubmed.ncbi.nlm.nih.gov/30108681
Publikováno v:
Genes & Cancer
The proto-oncogene MYC is a transcription factor over-expressed in many cancers and required for cell survival. Its function is regulated by histone acetyltransferase (HAT) complexes, such as the GCN5 complex and the NuA4/Tip60 complex. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ef784b6d3bd4e0bafbe5a173b0678d
https://pubmed.ncbi.nlm.nih.gov/29321817
https://pubmed.ncbi.nlm.nih.gov/29321817
Publikováno v:
Genes & Cancer
Expression of the adenovirus E1A N-terminal transcription repression domain alone (E1A 1-80) represses transcription from specific promoters such as HER2 [1] and from reconstituted chromatin [2]. Significantly, E1A 1-80 can induce the death of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9b8a5f8d73bf41cc676b067f98e423
https://doi.org/10.18632/genesandcancer.47
https://doi.org/10.18632/genesandcancer.47
Cellular transformation by adenovirus E1A requires targeting TRRAP, a scaffold protein which helps assemble histone acetyltransferase complexes, including the NuA4 complex. We recently reported that E1A and E1A 1-80 (N-terminal 80 aa) promote associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68884cf2e0f031b380a5c2de1d45481e
https://europepmc.org/articles/PMC5790114/
https://europepmc.org/articles/PMC5790114/
Autor:
Kathryn Plant, Philip L. Ritter, Diana Laurent, Siobhan M. Case, Maurice Green, Valarie Blue Bird Jernigan, Kate Lorig
Publikováno v:
Diabetes Care. 33:1275-1281
OBJECTIVEWe hypothesized that people with type 2 diabetes in an online diabetes self-management program, compared with usual-care control subjects, would 1) demonstrate reduced A1C at 6 and 18 months, 2) have fewer symptoms, 3) demonstrate increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5b1df194998beda4f974c487d858da5
https://doi.org/10.2337/dc09-2153
https://doi.org/10.2337/dc09-2153
Publikováno v:
Oncogene. 27:4446-4455
Extensive mutational/functional analysis of the transcription-repression domain encoded in the N-terminal 80 amino acids of the adenovirus E1A 243R oncoprotein suggests a model for the molecular mechanism of E1A repression: E1A accesses transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27c1397214a0e6eaf7abbd926e0018a
https://doi.org/10.1038/onc.2008.85
https://doi.org/10.1038/onc.2008.85
Publikováno v:
Virology. 351:312-321
Adenovirus early gene 1A (E1A) possesses a potent transcriptional repression function within the first 80 amino acids (E1A 1–80). Our previous analysis of subdomain 1 (residues 1 to 30) revealed strong correlations between residues required for rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723aec6dbf9d961d53a696dad8eba64a
https://doi.org/10.1016/j.virol.2006.03.041
https://doi.org/10.1016/j.virol.2006.03.041
Autor:
Maurice Green, Larry H. Bernstein
Publikováno v:
Point of Care: The Journal of Near-Patient Testing & Technology. 1:199-204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a43fbc9ce0b7a2bc64a0fd79defeff74
https://doi.org/10.1097/00134384-200209000-00014
https://doi.org/10.1097/00134384-200209000-00014