Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Maurice Goeldner"'
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42101 (2012)
Classical benzodiazepines, such as diazepam, interact with α(x)β(2)γ(2) GABA(A) receptors, x = 1, 2, 3, 5 and modulate their function. Modulation of different receptor isoforms probably results in selective behavioural effects as sedation and anxi
Externí odkaz:
https://doaj.org/article/b827e7fc0bfa4590b5ab484170e87469
Autor:
Cyril Herbivo, Josef Wachtveitl, Alexandre Specht, Stephan Junek, Maurice Goeldner, Manuela A. H. Fichte, Florian Schäfer, Xenia M. M. Weyel, Alexander Heckel
Publikováno v:
Angewandte Chemie (International ed. in English). 55(31)
We successfully introduced two-photon-sensitive photolabile groups ([7-(diethylamino)coumarin-4-yl]methyl and p-dialkylaminonitrobiphenyl) into DNA strands and demonstrated their suitability for three-dimensional photorelease. To visualize the uncagi
Autor:
Frédéric Bolze, Richard H. Kramer, Cyril Herbivo, Alexandre Mourot, David Warther, Jean-François Nicoud, Christopher M. Davenport, Loïc Donato, Maurice Goeldner, Jérémie Léonard, Alexandre Specht
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, 51 (8), pp.1840-1843. ⟨10.1002/anie.201106559⟩
HAL
Angewandte Chemie International Edition, 2012, 51 (8), pp.1840-1843. ⟨10.1002/anie.201106559⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, 51, pp.1840-1843
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, 51 (8), pp.1840-1843. ⟨10.1002/anie.201106559⟩
HAL
Angewandte Chemie International Edition, 2012, 51 (8), pp.1840-1843. ⟨10.1002/anie.201106559⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, 51, pp.1840-1843
By using two-photon (TP)[1] photoreleasable neurotransmitters like glutamate (Glu) or γ-aminobutyric acid (GABA), neuronal processes can be activated or inhibited with high temporal and spatial control (with around one micron three-dimensional preci
Autor:
Alexandre Specht, Raymond Brouillard, Marie Kueny-Stotz, Junichi Nabekura, Stefan Chassaing, Maurice Goeldner, Akiko Miyamoto, Mogens Nielsen, Adeline Martz, Lia Prado de Carvalho, Thomas Grutter, Hitoshi Ishibashi, Ruotian Jiang
Publikováno v:
British Journal of Pharmacology. 162:1326-1339
BACKGROUND AND PURPOSE Flavonoids, important plant pigments, have been shown to allosterically modulate brain GABAA receptors (GABAARs). We previously reported that trans-6,4′-dimethoxyretrochalcone (Rc-OMe), a hydrolytic derivative of the correspo
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:1023-1029
The search for chemical probes which allow a controlled fluorescence activation in living cells represent a major challenge in chemical biology. To be useful, such probes have to be specifically targeted to cellular proteins allowing thereof the anal
Publikováno v:
Journal of Neurochemistry. 106:2353-2363
Classical benzodiazepines, for example diazepam, interact with alpha(x)beta(2)gamma(2) GABA(A) receptors, x = 1, 2, 3, 5. Little is known about effects of alpha subunits on the structure of the binding pocket. We studied here the interaction of the c
Autor:
Rómulo Aráoz, Alexandre Mourot, Florian Krieger, Ernst Bamberg, Maurice Goeldner, Florence Kotzyba-Hibert, Jordi Molgó
Publikováno v:
ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2008, 9 (7), pp.1146-53. ⟨10.1002/cbic.200700757⟩
ChemBioChem, Wiley-VCH Verlag, 2008, 9 (7), pp.1146-53. ⟨10.1002/cbic.200700757⟩
We have synthesized a series of fluorescent acylcholine derivatives carrying different linkers that vary in length and structure and connect the acylcholine unit to the environment-sensitive fluorophores 7-(diethylamino)coumarin-3-carbonyl (DEAC) or
Autor:
Giuseppe Zaccai, Patrick Masson, Dominique Bourgeois, Antoine Royant, Martin Weik, Alexandre Specht, Florian Nachon, Joel L. Sussman, Maurice Goeldner, Jacques-Philippe Colletier, Israel Silman, Benoît Sanson
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 63:1115-1128
Acetylcholinesterase plays a crucial role in nerve-impulse transmission at cholinergic synapses. The apparent paradox that it displays high turnover despite its active site being buried raises cogent questions as to how the traffic of substrates and
Publikováno v:
Journal of Biological Chemistry. 282:26316-26325
Benzodiazepines are widely used drugs. They exert sedative/hypnotic, anxiolytic, muscle relaxant, and anticonvulsant effects and act through a specific high affinity binding site on the major inhibitory neurotransmitter receptor, the gamma-aminobutyr
Publikováno v:
Current Chemical Biology. 1:271-277