Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maurice D. Lee"'
Autor:
Wenye Sun, Zhenmin He, Adel M. Naylor-Olsen, Deming Xu, Joseph P. Vacca, Leanne Bedard, Ashlee M. Earl, Christina Scherer, Abigail L. Manson, Maurice D. Lee, Diane M Rush, Mark E. Fitzgerald, Mingliang Zhang, Huisheng Xu, Michelle Palmer, Joshua A. Bittker, Michael Foley, Jean-Charles Marie, Jeremy R. Duvall, Giovanni Muncipinto
Publikováno v:
ACS Infectious Diseases. 3:349-359
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options current
Autor:
Rachel Fearns, Qin Yu, Michael Foley, Paul Robert Fleming, Jeremy R. Duvall, Barbara Ludeke, Christina Scherer, Carol A. Mulrooney, Michelle Palmer, Maurice D. Lee, Karthick Vishwanathan, Sarah M. McLeod, Lynn VerPlank, Sebastian T. Le Quement
Publikováno v:
Antiviral Research. 131:19-25
Respiratory syncytial virus (RSV) infections affect millions of children and adults every year. Despite the significant disease burden, there are currently no safe and effective vaccines or therapeutics. We employed a replicon-based high throughput s
Publikováno v:
Future Medicinal Chemistry. 6:1927-1942
The development of resistance to existing antimicrobials has created a threat to human health that is not being addressed through our current drug pipeline. Limitations with the use of commercial vendor libraries and natural products have created a n
Autor:
Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis, Patrick McCarren, Giovanni Muncipinto, Ulf Norinder, Matthew W D Perry, Jeremy R Duvall, Jan Kihlberg
Publikováno v:
Nature chemical biology. 13(8)
Autor:
Daniela Masi, Keila N. Crespo-Llado, Amanda K. Lukens, Roger C. Wiegand, Dyann F. Wirth, Ann Rowley, Jeremy R. Duvall, Richard W. Heidebrecht, Mark E. Fitzgerald, Michael Foley, Adelfa E. Serrano, Nobutaka Kato, Stuart L. Schreiber, Marion Mercier, Benito Munoz, Carol A. Mulrooney, Christina Scherer, Eamon Comer, Maurice D. Lee, Michelle Palmer, Giovanni Muncipinto, Jennifer A. Beaudoin
Publikováno v:
Journal of Medicinal Chemistry
Here, we describe medicinal chemistry that was accelerated by a diversity-oriented synthesis (DOS) pathway, and in vivo studies of our previously reported macrocyclic antimalarial agent that derived from the synthetic pathway. Structure–activity re
Autor:
Carol A. Mulrooney, Morgan Welzel-O’Shea, Bérénice C. Lemercier, Edward B. Holson, Landon Durak, Sarathy Kesavan, Jeremy R. Duvall, Jingqiang Wei, Florence F. Wagner, Adrien Joliton, Laura M. Panko, Maurice D. Lee, Lisa A. Marcaurelle, Lakshmi B. Akella, Haibo Liu, Emeline L. Davoine, Jason T. Lowe, Méryl Thomas, Etienne J. Donckele, Michael Foley, Byung-Chul Suh, Giovanni Muncipinto, Ann Rowley, Jean-Charles Marie, Baudouin Gerard
Publikováno v:
The Journal of Organic Chemistry. 77:7187-7211
The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spirocyclic ring systems is described. The in vitro physicochemical and pharmacokinetic properties of represen
Autor:
Maurice D. Lee, Bhaumik A. Pandya, Jean-Charles Marie, Haibo Liu, Baudouin Gerard, Lisa A. Marcaurelle
Publikováno v:
The Journal of Organic Chemistry. 76:1898-1901
All stereoisomers of a highly functionalized 2,3-unsaturated C-glycoside can be accessed in 10-100 g quantities from readily available starting materials and reagents in 3-7 steps. These chiral scaffolds contain three stereogenic centers along with o
Autor:
Troy D. Ryba, Maurice D. Lee, Stephen J. Haggarty, Surya A. Reis, Eamon Comer, Nathan T. Ross, Jingqiang Wei, Byung-Chul Suh, Michael Foley, Lakshmi B. Akella, Haibo Liu, Jason T. Lowe, Yan-Ling Zhang, Wen-Ning Zhao, Jeremy R. Duvall, Daniel M. Fass, Damian W. Young, Carol Mulrooney, Lisa A. Marcaurelle, Bhaumik A. Pandya, Ann Rowley, Michelle Palmer, Baudouin Gerard, Sivaraman Dandapani, Sarathy Kesavan, Jean-Charles Marie
Publikováno v:
Journal of the American Chemical Society. 132:16962-16976
An aldol-based ‘build/couple/pair’ (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules. In the build phase, a series of asymmetric syn- and anti- aldol reactions were performed to produ
Autor:
Lanny S. Liebeskind, Maurice D. Lee, Wenyong Chen, Matthew J Armstrong, Heilam Wong, Bo Cheng, Thomas C. Coombs, and Alessandro F. Moretto
Publikováno v:
The Journal of Organic Chemistry. 73:882-888
A unified strategy for the high-throughput synthesis of multigram quantities of the eta(3)-oxopyranyl- and eta(3)-oxopyridinylmolybdenum complexes TpMo(CO)(2)(eta(3)-oxopyranyl) and TpMo(CO)(2)(eta(3)-oxopyridinyl) is described (Tp = hydridotrispyraz
Autor:
Stephen Johnston, Björn Over, Pär Matsson, Jeremy R Duvall, Constanze Hilgendorf, Richard J. Lewis, Giovanni Muncipinto, Jan Kihlberg, Per Artursson, Christian Tyrchan, Ulf Norinder, Michael Foley, Perry Matthew, Patrick McCarren, Maurice D. Lee, Bradley C. Doak
Publikováno v:
Nature chemical biology. 12(12)
Macrocycles are of increasing interest as chemical probes and drugs for intractable targets like protein-protein interactions, but the determinants of their cell permeability and oral absorption are poorly understood. To enable rational design of cel