Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Maurice B Loughrey"'
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0300357 (2024)
BackgroundWe investigated the impact of the COVID-19 pandemic on trends of presentation, management and pathology findings in patients who underwent an appendicectomy for suspected acute appendicitis.MethodThe retrospective study reviewed patients (n
Externí odkaz:
https://doaj.org/article/4d0107d9319940a8b77cf48eda714401
Autor:
Ashleigh C. Hamilton, Finian J. Bannon, Philip D. Dunne, Jacqueline James, Stephen McQuaid, Ronan T. Gray, Manuel Salto-Tellez, Chris R. Cardwell, Maurice B. Loughrey, Helen G. Coleman
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 3, Pp 347-359 (2023)
Background and Aims: The observed increase in the incidence of early-onset colorectal cancer (EOCRC) is being driven by sporadic cases, but the molecular characteristics of these tumors are not fully understood. Our objective was to investigate the p
Externí odkaz:
https://doaj.org/article/8d691786c5d14cfba3e309cbd980f469
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gundaz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor sign
Externí odkaz:
https://doaj.org/article/685f337608c24440b7e084866104173a
Autor:
Stephanie G. Craig, Svenja Mende, Matthew P. Humphries, Victoria Bingham, Amélie Viratham Pulsawatdi, Maurice B. Loughrey, Helen G. Coleman, Stephen McQuaid, Richard H. Wilson, Sandra Van Schaeybroeck, Jacqueline A. James, Manuel Salto‐Tellez
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3317-3328 (2021)
Clinical trials for MET inhibitors have demonstrated limited success for their use in colon cancer (CC). However, clinical efficacy may be obscured by a lack of standardisation in MET assessment for patient stratification. In this study, we aimed to
Externí odkaz:
https://doaj.org/article/0b8be54a07784f57bd958f3c8b5f5b03
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gunduz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d890b609d092453794d4b110a230e27b
Autor:
Sandra Van Schaeybroeck, Manuel Salto-Tellez, Mark Lawler, Patrick G. Johnston, Elaine W. Kay, Daniel B. Longley, Peter W. Hamilton, David J. Waugh, Simon S. McDade, Wendy L. Allen, Maurice B. Loughrey, Ken Arthur, Tony O'Grady, Robert Cummins, Helen L. Barrett, Paul G. O'Reilly, Conor A. Bradley, Darragh G. McArt, Philip D. Dunne
Supplementary Table 4: Differentially expressed gene list contrasting tumour region of origin between Lymph Node and Invasive Front.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db6a0d15578bf77aaaf65daeebecfb3
https://doi.org/10.1158/1078-0432.22463084
https://doi.org/10.1158/1078-0432.22463084
Autor:
Philip D. Dunne, Nigel B. Jamieson, Viktor H. Koelzer, Felicity Lamrock, Owen J. Sansom, Mark Lawler, Tim Maughan, Simon Leedham, Maurice B. Loughrey, James Jackson, Enric Domingo, Svetlana Sakhnevych, Keara L. Redmond, Emily Rogan, Aoife J. McCooey, Raheleh Amirkhah, Sudhir B. Malla, Shania M. Corry, Baharak Ahmaderaghi, Andrew J. Cameron, Assya Legrini, Colin Wood, Holly Leslie, Ryan M. Byrne, Natalie C. Fisher
Supplementary Figure from Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0771c16776581bd680a135636aaa9b65
https://doi.org/10.1158/1078-0432.22487885
https://doi.org/10.1158/1078-0432.22487885
Autor:
Sandra Van Schaeybroeck, Manuel Salto-Tellez, Mark Lawler, Patrick G. Johnston, Elaine W. Kay, Daniel B. Longley, Peter W. Hamilton, David J. Waugh, Simon S. McDade, Wendy L. Allen, Maurice B. Loughrey, Ken Arthur, Tony O'Grady, Robert Cummins, Helen L. Barrett, Paul G. O'Reilly, Conor A. Bradley, Darragh G. McArt, Philip D. Dunne
Purpose: A number of independent gene expression profiling studies have identified transcriptional subtypes in colorectal cancer with potential diagnostic utility, culminating in publication of a colorectal cancer Consensus Molecular Subtype classifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2659102c09a5860345e0b7360d9dc6f3
https://doi.org/10.1158/1078-0432.c.6525305
https://doi.org/10.1158/1078-0432.c.6525305
Autor:
Marie M. Cantwell, Vivienne McConnell, Patrick B. Allen, Shivaram K. Bhat, Martha J. Shrubsole, Anna T. Gavin, Brian T. Johnston, Liam J. Murray, Maurice B. Loughrey, Helen G. Coleman
Supplementary Table 1. Sensitivity analysis excluding 1 year follow-up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67361839dc6e106533c229f07e62907e
https://doi.org/10.1158/1055-9965.22438101
https://doi.org/10.1158/1055-9965.22438101
Autor:
Marie M. Cantwell, Vivienne McConnell, Patrick B. Allen, Shivaram K. Bhat, Martha J. Shrubsole, Anna T. Gavin, Brian T. Johnston, Liam J. Murray, Maurice B. Loughrey, Helen G. Coleman
Background: Randomized controlled trials have demonstrated significant reductions in colorectal cancer incidence and mortality associated with polypectomy. However, little is known about whether polypectomy is effective at reducing colorectal cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0302827da9fb8a64900c41116e758a
https://doi.org/10.1158/1055-9965.c.6516207.v1
https://doi.org/10.1158/1055-9965.c.6516207.v1