Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Maurice A. Marsini"'
Autor:
Maxim Cheveliakov, Matt Hrapchak, Carl A. Busacca, Jonathan T. Reeves, Bachir Latli, Chris H. Senanayake, Maurice A. Marsini
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 61:764-772
1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide (1) and its analogs (2) and (3) are potent CCR1 antagonists intended for the treatment of rheumatoid arthritis. The detailed syntheses of the
Autor:
Jon C. Lorenz, Laurence J. Nummy, Xudong Wei, Jason Brazzillo, Irungu K. Luvaga, Chris H. Senanayake, Zhulin Tan, Jinhua J. Song, Bikshandarkoil A. Narayanan, Kanwar Sidhu, Nathan K. Yee, Maurice A. Marsini, Frederic G. Buono, Jonathan T. Reeves, Heewon Lee, Yongda Zhang, Max Sarvestani, Bing-Shiou Yang, Ning Li, Frank Roschangar, J. C. Chung
Publikováno v:
Green Chemistry. 19:1454-1461
A convergent, robust, and concise synthesis of a developmental CCR1 antagonist is described using continuous flow technology. In the first approach, following an expeditious SNAr sequence for cyclopropane introduction, a safe, continuous flow Curtius
Autor:
Melissa A. Herbage, Maurice A. Marsini, Jolaine Savoie, Daniel Rivalti, Jean-Nicolas Desrosiers, Keith R. Fandrick, Joshua D. Sieber, Yongda Zhang, Chris H. Senanayake
Publikováno v:
Organic Reactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed1a1241fc99dc180a23e84d00462ac8
https://doi.org/10.1002/0471264180.or099.01
https://doi.org/10.1002/0471264180.or099.01
Autor:
Maurice A. Marsini, Joshuaine Grant, Jon C. Lorenz, Christian Harcken, Frederic G. Buono, Jonathan T. Reeves, Hossein Razavi
Publikováno v:
ACS Symposium Series ISBN: 9780841234321
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a36e6f41d98e48bc6e0f8ed35a62e81
https://doi.org/10.1021/bk-2019-1332.ch008
https://doi.org/10.1021/bk-2019-1332.ch008
Autor:
Jaan A. Pesti, Ahmed F. Abdel-Magid, Rajappa Vaidyanathan, Yi-Yin Ku, Michael D. Wendt, Robert Dugger, Bryan Li, Paul Richardson, Rémy Angelaud, Steve Staben, Timothy Heffron, Andreas Schuster, Frédéric St-Jean, Stefan G. Koenig, Thomas H. Pillow, Andreas Stumpf, Daniel Sutherlin, Christoph M. Dehnhardt, Neil F. Langille, Daniel B. Horne, David C. Blakemore, Thomas Brandt, Craig Knight, Sarah E. Skerratt, Christian Harcken, Joshuaine Grant, Hossein Razavi, Maurice A. Marsini, Frederic G. Buono, Jon C. Lorenz, Jonathan T. Reeves, James J. Crawford, Haiming Zhang, David W. Piotrowski, Emma L. McInturff, Andrew J. Peat, Shiping Xie
Autor:
C. Avery Sader, Christian A. Malapit, Maurice A. Marsini, Frederic G. Buono, Kanwar Sidhu, Keith R. Fandrick, Chris H. Senanayake, Jonathan T. Reeves, Carl A. Busacca
Publikováno v:
Journal of the American Chemical Society. 137:9481-9488
An electrophilic cyanation of aryl Grignard or lithium reagents, generated in situ from the corresponding aryl bromides or iodides, by a transnitrilation with dimethylmalononitrile (DMMN) was developed. DMMN is a commercially available, bench-stable
Autor:
DiAndra M. Rudzinski, Frank Roschangar, Bo Qu, Jinhua J. Song, Shengli Ma, Anji Chen, Guijun Wang, Jean-Nicolas Desrosiers, Lalith P. Samankumara, Zhengxu S. Han, Nathan K. Yee, Chris H. Senanayake, Yibo Xu, Zhibin Li, Keith R. Fandrick, Nelu Grinberg, Jonathan T. Reeves, Nitinchandra D. Patel, Li Zhang, Maurice A. Marsini, Joshua D. Sieber
Publikováno v:
Angewandte Chemie. 127:5564-5567
The use of chiral phosphinamides is relatively unexplored because of the lack of a general method for the synthesis. Reported herein is the development of a general, efficient, and highly enantioselective method for the synthesis of structurally dive
Autor:
Michael D. Visco, Ivan Volchkov, Anita E. Mattson, Chris H. Senanayake, Jonathan T. Reeves, Carl A. Busacca, Maurice A. Marsini
Publikováno v:
Tetrahedron Letters. 57:1903-1905
Triisopropyl borate effects the condensation of aldehydes with sulfinamides to give N -sulfinyl imines. The reaction is amenable to 1°, 2°, and 3° alkyl aldehydes, as well as aryl, heteroaryl, and α,β-unsaturated aldehydes. In addition to tert -
Autor:
Nitinchandra D. Patel, Xudong Wei, Nizar Haddad, Marisa C. Kozlowski, Jon C. Lorenz, Frank Himmelsbach, Nathan K. Yee, Zhulin Tan, Scot Campbell, Sergei Tcyrulnikov, Jun Wang, Chris H. Senanayake, Jean-Nicolas Desrosiers, Stefan Peters, Xingzhong Zeng, Maurice A. Marsini, Frederic G. Buono, Zhibin Li, Jolaine Savoie, Frank Roschangar, Bing-Shiou Yang, Keith R. Fandrick, Matthias Eckhardt, Heewon Lee, Wenjun Tang, Bo Qu, Jinhua J. Song, Shengli Ma, Osvaldo Gutierrez
Publikováno v:
Journal of the American Chemical Society. 138(47)
A concise asymmetric synthesis of an 11β-HSD-1 inhibitor has been achieved using inexpensive starting materials with excellent step-economy at low catalyst loadings. The catalytic enantioselective total synthesis of 1 was accomplished in 7 steps and
Autor:
Dajun Chen, Bo Qu, Bruce Z. Lu, Carl A. Busacca, Keith R. Fandrick, Nicole Grět, Anjan Saha, Yaping Hong, Zhibin Li, Nizar Haddad, Diana C. Reeves, Shengli Ma, Jiang Ping Wu, Chris H. Senanayake, Magnus C. Eriksson, Heewon Lee, Nelu Grinberg, Maurice A. Marsini
Publikováno v:
Advanced Synthesis & Catalysis. 355:1455-1463
The modular nature of the BIPI ligands allows for systematic optimization of each ligand region. The development of ligands optimized for asymmetric hydrogenation of the challenging unfunctionalized olefin substrate class is described. The naphthyl p