Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maureen Spit"'
Publikováno v:
Open Biology, Vol 8, Iss 9 (2018)
Rapidly renewing tissues such as the intestinal epithelium critically depend on the activity of small-sized stem cell populations that continuously generate new progeny to replace lost and damaged cells. The complex and tightly regulated process of i
Externí odkaz:
https://doaj.org/article/2e02d3d430a947cd8f934c8bafa7c84b
Publikováno v:
Haematologica, Vol 101, Iss 11 (2016)
Interleukin-7 and interleukin-7 receptor are essential for normal T-cell development and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated signaling promotes leukemogenesis. The protein kinase, casein kinase 2, is overexpre
Externí odkaz:
https://doaj.org/article/ccfa483d02344d67abd8c76fc34181a7
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology, 55(6), 691-715. TAYLOR & FRANCIS LTD
Transforming growth factor beta (TGF-beta) family members play an extensive role in cellular communication that orchestrates both early development and adult tissue homeostasis. Aberrant TGF-beta family signaling is associated with a pathological out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a701e3ebb0ecc42fc4f381886c0ef5
https://pubmed.ncbi.nlm.nih.gov/33081543
https://pubmed.ncbi.nlm.nih.gov/33081543
Autor:
Maureen Spit, Peter ten Dijke
Publikováno v:
Encyclopedia of Molecular Pharmacology ISBN: 9783030215736
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f251f22e8a6180acfbcb9b0d0a7fccb2
https://doi.org/10.1007/978-3-030-21573-6_10062-1
https://doi.org/10.1007/978-3-030-21573-6_10062-1
Autor:
Michiel Vermeulen, Madelon M. Maurice, Lars Ootes, Maureen Spit, Jeroen M. Bugter, Sylvia F. Boj, Tomasz Witold Radaszkiewicz, Jan Paul Medema, Alba Cristobal, Katerina Hanakova, Max van Osch, Eline Janssen, Vitezslav Bryja, Bon-Kyoung Koo, David Potesil, Zbynek Zdrahal, Kim E. Boonekamp, Rik G.H. Lindeboom, Ingrid Jordens, Nicola Fenderico
Publikováno v:
The EMBO Journal
EMBO journal, 39(18):e103932. Wiley-Blackwell
EMBO Journal, 39
EMBO Journal, 39, 18
EMBO journal, 39(18):e103932. Wiley-Blackwell
EMBO Journal, 39
EMBO Journal, 39, 18
Wnt/β‐catenin signaling is a primary pathway for stem cell maintenance during tissue renewal and a frequent target for mutations in cancer. Impaired Wnt receptor endocytosis due to loss of the ubiquitin ligase RNF43 gives rise to Wnt‐hypersensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b84d9dcdeaac5c466359d7c0fc3c390
https://pubmed.ncbi.nlm.nih.gov/32965059
https://pubmed.ncbi.nlm.nih.gov/32965059
Publikováno v:
Journal of cell science. 132(2)
Ubiquitination (also known as ubiquitylation) is a post-translational modification that creates versatility in cell signalling and regulates a multitude of cellular processes. Its versatility lies in the capacity to form eight different inter-ubiquit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1746445c9963310232cebaf3de0631
https://pubmed.ncbi.nlm.nih.gov/30659056
https://pubmed.ncbi.nlm.nih.gov/30659056
Autor:
Elodie, Lafont, Chahrazade, Kantari-Mimoun, Peter, Draber, Diego, De Miguel, Torsten, Hartwig, Matthias, Reichert, Sebastian, Kupka, Yutaka, Shimizu, Lucia, Taraborrelli, Maureen, Spit, Martin R, Sprick, Henning, Walczak
Publikováno v:
The EMBO journal. 36(9)
TNF receptor‐1 (TNFR1) and TRAIL death receptors preferentially induce pro‐inflammatory or cytotoxic signaling, respectively, via distinct plasma membrane and cytosolic complexes. New studies identifying the pro‐inflammatory factors TRAF2, RIP,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::307921ca7fcf85ab1319e44ccd41204f
https://pubmed.ncbi.nlm.nih.gov/28400401
https://pubmed.ncbi.nlm.nih.gov/28400401
Publikováno v:
Haematologica
Interleukin-7 and interleukin-7 receptor are essential for normal T-cell development and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated signaling promotes leukemogenesis. The protein kinase, casein kinase 2, is overexpre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37637086b954a2aec7ed204ee5c356b
Autor:
Hans Clevers, Albert J. R. Heck, Teck Yew Low, Johan H. van Es, Daniel E. Stange, Madelon M. Maurice, Marc van de Wetering, Ingrid Jordens, Shabaz Mohammed, Maureen Spit, Bon-Kyoung Koo
Publikováno v:
Nature; Vol 488
Nature, 488(7413), 665-669. Nature Publishing Group
Nature, 488(7413), 665-669. Nature Publishing Group
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the related RNF43 and ZNRF3 transmembrane E3 ubiquitin ligases are uniquely expressed in LGR5+ ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3695e8ef53f442887eead32b53d0cba6
http://ora.ox.ac.uk/objects/uuid:2e12aea4-5c33-4d9d-8ab1-cb65c2a31a39
http://ora.ox.ac.uk/objects/uuid:2e12aea4-5c33-4d9d-8ab1-cb65c2a31a39
Autor:
Saskia W.C. van Mil, Leo W.J. Klomp, Stefania Murzilli, Bas Oldenburg, Ellen C.L. Willemsen, Raffaella Maria Gadaleta, Peter D. Siersema, Maureen Spit, Karel J. van Erpecum, Lorena Salvatore
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (8):851-858
Hyperactivation of NF-κB is a key factor in the pathophysiology of inflammatory bowel disease (IBD). We previously showed that the bile salt nuclear Farnesoid X Receptor (FXR) counter-regulates intestinal inflammation, possibly via repression of NF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13de8db05cf7e70833234b82b33a97c