Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maureen R, Newman"'
Publikováno v:
Curr Osteoporos Rep
PURPOSE OF REVIEW: The clinical significance, target pathways, recent successes, and challenges that preclude translation of RNAi bone regenerative approaches are overviewed. RECENT FINDINGS: RNA interference (RNAi) is a promising new therapeutic app
Autor:
Maureen R. Newman, David Fraser, Amy H. Van Hove, Yiming Li, Danielle S. W. Benoit, Jared A. Mereness, Sayantani Basu
Publikováno v:
ACS Appl Bio Mater
Craniofacial tissue injuries, diseases, and defects, including those within bone, dental, and periodontal tissues and salivary glands, impact an estimated 1 billion patients globally. Craniofacial tissue dysfunction significantly reduces quality of l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811375b032c4ee2678c9aa5177a40ebe
https://europepmc.org/articles/PMC9016342/
https://europepmc.org/articles/PMC9016342/
Publikováno v:
J Biomed Mater Res A
Despite efforts to achieve tissue selectivity, the majority of systemically administered drug delivery systems (DDSs) are cleared by the mononuclear phagocyte system (MPS) before reaching target tissues regardless of disease or injury pathology. Prev
Autor:
Yuchen, Wang, Maureen R, Newman, Marian, Ackun-Farmmer, Michael P, Baranello, Tzong-Jen, Sheu, J Edward, Puzas, Danielle S W, Benoit
Publikováno v:
ACS nano. 14(4)
Despite several decades of progress, bone-specific drug delivery is still a major challenge. Current bone-acting drugs require high-dose systemic administration which decreases therapeutic efficacy and increases off-target tissue effects. Here, a bon
Publikováno v:
Bioconjugate Chemistry. 29:2161-2169
Therapeutic compounds with narrow therapeutic windows and significant systemic side effects benefit from targeted drug delivery strategies. Peptide-protein interactions are often exploited for targeting, with phage display a primary method to identif
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 127:223-236
Impaired fracture healing is a major clinical problem that can lead to patient disability, prolonged hospitalization, and significant financial burden. Although the majority of fractures heal using standard clinical practices, approximately 10% suffe
Publikováno v:
RSC Advances. 8:28891-28894
A systematic approach to the synthesis of organocatalyzed oligo(d,l-lactide) demonstrates that choice of initiator, catalytic ratio, and reaction time yields well-controlled oligomers. Ring-opening polymerization of d,l-lactide with the initiator α-
Autor:
Tzong-Jen Sheu, Steven G. Russell, Christopher S. Schmitt, Danielle S. W. Benoit, J. Edward Puzas, Maureen R. Newman, Ian A. Marozas
Publikováno v:
Biomacromolecules. 19:71-84
Drug delivery to bone is challenging, whereby drug distribution is commonly
Autor:
Michael P. Baranello, Tzong-Jen Sheu, Marian A. Ackun-Farmmer, Maureen R. Newman, J. Edward Puzas, Danielle S. W. Benoit, Yuchen Wang
Publikováno v:
ACS Nano. 14:5149-5150
Publikováno v:
Current Opinion in Biotechnology. 40:125-132
While experimental bone regeneration approaches commonly employ cells, technological hurdles prevent translation of these therapies. Alternatively, emulating the spatiotemporal cascade of endogenous factors through controlled drug delivery may provid