Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Maureen P Martin"'
Autor:
Vinicius A Vieira, Emily Adland, David F G Malone, Maureen P Martin, Andreas Groll, M Azim Ansari, Maria C Garcia-Guerrero, Mari C Puertas, Maximilian Muenchhoff, Claudia Fortuny Guash, Christian Brander, Javier Martinez-Picado, Alasdair Bamford, Gareth Tudor-Williams, Thumbi Ndung'u, Bruce D Walker, Veron Ramsuran, John Frater, Pieter Jooste, Dimitra Peppa, Mary Carrington, Philip J R Goulder
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010090 (2021)
Natural Killer (NK) cells contribute to HIV control in adults, but HLA-B-mediated T-cell activity has a more substantial impact on disease outcome. However, the HLA-B molecules influencing immune control in adults have less impact on paediatric infec
Externí odkaz:
https://doaj.org/article/2772898860cf475e98f5416e7e2940e4
Autor:
Haoyan Chen, Genki Hayashi, Olivia Y Lai, Alexander Dilthey, Peter J Kuebler, Tami V Wong, Maureen P Martin, Marcelo A Fernandez Vina, Gil McVean, Matthias Wabl, Kieron S Leslie, Toby Maurer, Jeffrey N Martin, Steven G Deeks, Mary Carrington, Anne M Bowcock, Douglas F Nixon, Wilson Liao
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002514 (2012)
An important paradigm in evolutionary genetics is that of a delicate balance between genetic variants that favorably boost host control of infection but which may unfavorably increase susceptibility to autoimmune disease. Here, we investigated whethe
Externí odkaz:
https://doaj.org/article/fc56704df8ae4f7d9559dc00704ddde4
Autor:
Kimberly Pelak, Anna C Need, Jacques Fellay, Kevin V Shianna, Sheng Feng, Thomas J Urban, Dongliang Ge, Andrea De Luca, Javier Martinez-Picado, Steven M Wolinsky, Jeremy J Martinson, Beth D Jamieson, Jay H Bream, Maureen P Martin, Persephone Borrow, Norman L Letvin, Andrew J McMichael, Barton F Haynes, Amalio Telenti, Mary Carrington, David B Goldstein, Galit Alter, NIAID Center for HIV/AIDS Vaccine Immunology
Publikováno v:
PLoS Biology, Vol 9, Iss 11, p e1001208 (2011)
A genome-wide screen for large structural variants showed that a copy number variant (CNV) in the region encoding killer cell immunoglobulin-like receptors (KIR) associates with HIV-1 control as measured by plasma viral load at set point in individua
Externí odkaz:
https://doaj.org/article/a88a6a17ab4c48cbaa44f406101588bf
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000254 (2008)
Natural killer (NK) cells play an important role in the detection and elimination of tumors and virus-infected cells by the innate immune system. Human NK cells use cell surface receptors (KIR) for class I MHC to sense alterations of class I on poten
Externí odkaz:
https://doaj.org/article/8ab85f9b42644986b289afedce7d77a9
Autor:
Ying Qi, Maureen P Martin, Xiaojiang Gao, Lisa Jacobson, James J Goedert, Susan Buchbinder, Gregory D Kirk, Stephen J O'Brien, John Trowsdale, Mary Carrington
Publikováno v:
PLoS Pathogens, Vol 2, Iss 8, p e79 (2006)
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direc
Externí odkaz:
https://doaj.org/article/2eb94a0610664669965efe7eb331ecca
Autor:
Vitor R. C. Aguiar, Erick C. Castelli, Richard M. Single, Arman Bashirova, Veron Ramsuran, Smita Kulkarni, Danillo G. Augusto, Maureen P. Martin, Maria Gutierrez-Arcelus, Mary Carrington, Diogo Meyer
Publikováno v:
Immunogenetics. 75:249-262
Autor:
Behzad Etemad, Xiaoming Sun, Yijia Li, Meghan Melberg, Daniela Moisi, Rachel Gottlieb, Hayat Ahmed, Evgenia Aga, Ronald J. Bosch, Edward P. Acosta, Yuko Yuki, Maureen P. Martin, Mary Carrington, Rajesh T. Gandhi, Jeffrey M. Jacobson, Paul Volberding, Elizabeth Connick, Ronald Mitsuyasu, Ian Frank, Michael Saag, Joseph J. Eron, Daniel Skiest, David M. Margolis, Diane Havlir, Robert T. Schooley, Michael M. Lederman, Xu G. Yu, Jonathan Z. Li
Publikováno v:
Proceedings of the National Academy of Sciences. 120
HIV post-treatment controllers (PTCs) are rare individuals who maintain low levels of viremia after stopping antiretroviral therapy (ART). Understanding the mechanisms of HIV post-treatment control will inform development of strategies aiming at achi
Autor:
Victoria, Walker-Sperling, Jean C, Digitale, Mathias, Viard, Maureen P, Martin, Arman, Bashirova, Yuko, Yuki, Veron, Ramsuran, Smita, Kulkarni, Vivek, Naranbhai, Hongchuan, Li, Stephen K, Anderson, Lauren, Yum, Robert, Clifford, Hannah, Kibuuka, Julie, Ake, Rasmi, Thomas, Sarah, Rowland-Jones, John, Rek, Emmanuel, Arinaitwe, Moses, Kamya, Isabel, Rodriguez-Barraquer, Margaret E, Feeney, Mary, Carrington
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(29)
HLA class I (HLA-I) allotypes vary widely in their dependence on tapasin (TAPBP), an integral component of the peptide-loading complex, to present peptides on the cell surface. We identified two single-nucleotide polymorphisms that regulate
Autor:
Charlotte Sarfas, Andrew White, Stephan Günther, Mandy Kader Kondé, Y. Yuki, K. Ewer, Mary Carrington, Stephanie Longet, Laura Sibley, Miles W. Carroll, Tom Tipton, Jack Mellors, Maureen P. Martin, Yper Hall, Joseph Akoi Bore
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Nature Communications
Zaire ebolavirus (EBOV) is a highly pathogenic filovirus which can result in Ebola virus disease (EVD); a serious medical condition that presents as flu like symptoms but then often leads to more serious or fatal outcomes. The 2013–16 West Africa e
Autor:
Geoffrey T. Ivison, Elena Vendrame, Giovanny J. Martínez-Colón, Thanmayi Ranganath, Rosemary Vergara, Nancy Q. Zhao, Maureen P. Martin, Sean C. Bendall, Mary Carrington, Joshua C. Cyktor, Deborah K. McMahon, Joseph Eron, R. Brad Jones, John W. Mellors, Ronald J. Bosch, Rajesh T. Gandhi, Susan Holmes, Catherine A. Blish, The ACTG 5321 Team
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The latent HIV-1 reservoir represents a major barrier to achieving a long-term antiretroviral therapy (ART)-free remission or cure for HIV-1. Natural Killer (NK) cells are innate immune cells that play a critical role in controlling viral infections