Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maureen O'Connor McCourt."'
Autor:
Lilian Varricchio, Camelia Iancu-Rubin, Bhaskar Upadhyaya, Maria Zingariello, Fabrizio Martelli, Paola Verachi, Cara Clementelli, Jean-Francois Denis, Adeeb H. Rahman, Gilles Tremblay, John Mascarenhas, Ruben A. Mesa, Maureen O’Connor-McCourt, Anna Rita Migliaccio, Ronald Hoffman
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Myelofibrosis (MF) is a progressive chronic myeloproliferative neoplasm characterized by hyperactivation of JAK/STAT signaling and dysregulation of the transcription factor GATA1 in megakaryocytes (MKs). TGF-β plays a pivotal role in the pathobiolog
Externí odkaz:
https://doaj.org/article/aa050974d8234556ab4fc5e42238e3c0
Autor:
Anne E.G. Lenferink, Paul C. McDonald, Christiane Cantin, Suzanne Grothé, Mylene Gosselin, Jason Baardsnes, Myriam Banville, Paul Lachance, Alma Robert, Yuneivy Cepero-Donates, Stevo Radinovic, Patrick Salois, Marie Parat, Hafida Oamari, Annie Dulude, Mehul Patel, Martin Lafrance, Andrea Acel, Nathalie Bousquet-Gagnon, Denis L’Abbé, Alex Pelletier, Félix Malenfant, Maria Jaramillo, Maureen O’Connor-Mccourt, Cunle Wu, Yves Durocher, Mélanie Duchesne, Christine Gadoury, Anne Marcil, Yves Fortin, Beatrice Paul-Roc, Maurizio Acchione, Shawn C. Chafe, Oksana Nemirovsky, Joseph Lau, Francois Bénard, Shoukat Dedhar
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The architectural complexity and heterogeneity of the tumor microenvironment (TME) remains a substantial obstacle in the successful treatment of cancer. Hypoxia, caused by insufficient oxygen supply, and acidosis, resulting from the expulsion of acid
Externí odkaz:
https://doaj.org/article/a78bd5c3c72d4143937f4cd8eec87eef
Autor:
Naif Zaman, Lei Li, Maria Luz Jaramillo, Zhanpeng Sun, Chabane Tibiche, Myriam Banville, Catherine Collins, Mark Trifiro, Miltiadis Paliouras, Andre Nantel, Maureen O’Connor-McCourt, Edwin Wang
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 216-223 (2013)
Individual cancer cells carry a bewildering number of distinct genomic alterations (e.g., copy number variations and mutations), making it a challenge to uncover genomic-driven mechanisms governing tumorigenesis. Here, we performed exome sequencing o
Externí odkaz:
https://doaj.org/article/c5734c4ca3ab46809467df3d61abd8ef
Autor:
Qinghua Cui, Yun Ma, Maria Jaramillo, Hamza Bari, Arif Awan, Song Yang, Simo Zhang, Lixue Liu, Meng Lu, Maureen O'Connor‐McCourt, Enrico O Purisima, Edwin Wang
Publikováno v:
Molecular Systems Biology, Vol 3, Iss 1, Pp 1-13 (2007)
Abstract We conducted a comprehensive analysis of a manually curated human signaling network containing 1634 nodes and 5089 signaling regulatory relations by integrating cancer‐associated genetically and epigenetically altered genes. We find that c
Externí odkaz:
https://doaj.org/article/bb82f4b756454fc0b84d61d76e1c433d
Publikováno v:
BioTechniques, Vol 27, Iss 1, Pp 60-62 (1999)
Externí odkaz:
https://doaj.org/article/4ef2256bf37545a9a62df70cfe1a190d
Autor:
Maureen O'Connor-McCourt, Alejandro Cohen, Kenneth A. Chisholm, Edwin Wang, Devanand M. Pinto, Ripsik Kostyleva
Publikováno v:
Journal of Proteomics. 81:135-147
Proteins secreted or shed by cancerous cells are seen as a rich source of biomarkers and novel therapeutic targets. Recently, the importance of the tumor microenvironment, which comprises the surrounding non-tumor cells, has received increased attent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7796929492a98e5f7d34e758dc0be595
https://doi.org/10.1016/j.jprot.2012.11.004
https://doi.org/10.1016/j.jprot.2012.11.004
Autor:
Gerald Steiner, Stefan Rutkowski, David M. Loeb, Jochen Herms, Samuel D. Rabkin, G.J. Kaspers, Ling-Yuan Kong, Reiner Salzer, Tokomo Ozawa, Anneke C. Navis, Rob C. Hoeben, John J. Lannutti, Nalin Gupta, ZhaoBin Zhang, Alfredo Quinones-Hinojosa, Dolores Hambardzumyan, Jon D. Weingart, Mariano S. Viapiano, Michał Nowicki, Gregory J. Riggins, Celina Crisman, Chen Gang, Elena I. Fomchenko, Martine L.M. Lamfers, Yuan Rong, Carol Tucker-Burden, I Zondervan, P. Wesseling, Deepak Kamnasaran, Enio A. Chiocca, Jose Bergeron, Julia Sisti, Sanne K. van den Hengel, Anat Stemmer-Rachamimov, Nikolaus Schultz, Gabriele Schackert, Jun Wei, Jonathan P. Yun, Bob C. Hamans, Fabien G. Lafaille, Shengguo Li, Amparo Wolf, Paula A. Agudelo, Jochem K H Spoor, Rolf Bjerkvig, Abhijit Guha, Sameer Agnihotri, Preeti Shah, Andreas Lorenz, Gregory N. Fuller, Xiaoyan Zhu, Nesrin Sabha, Michael Lim, Stephen Yip, Frits Thorsen, Viviane Tabar, Allison Stelling, Judith W. M. Jeuken, William T. Curry, Arend Heerschap, Nduka Amankulor, Hiroaki Wakimoto, Lakshmi Katuri, Yasuyuki Aoki, Hadie Adams, Jenneke Kloezeman, Raelene Endersby, P. van der Valk, T. Wurdinger, Wesley Hsu, André Von Bueren, Antonio Aliaga, Suzanne J. Baker, Matthias Kirsch, David W. Ellison, Sander Idema, Yuhui Yang, Norbert Ajewung, Massimo Squatrito, C. Molthoff, D. H. Meijer, Gayatry Mohapatra, Pim J. French, Rutger K. Balvers, An Claes, M. Bugiani, Hans A. Kretzschmar, Michael Castelli, Pui K. Li, Thomas Kosztowski, Ganesh Rao, Zev A. Binder, W. Vos, M. Barazas, Eric C. Holland, Amanda M. Katz, Anne Kleijn, Chunxu Qu, Jeffrey N. Bruce, P.M. van der Stoop, Robert L. Martuza, Sidney Croul, Ahmed Mohyeldin, Shante Williams, Jed Johnson, Heike Immervoll, Aurelia Peraud, W.P. Vandertop, Sherri Rankin, Erwin Van Meir, Anne Lenferink, Adam Studebaker, Amy B. Heimberger, Lorenz Studer, Clemens M F Dirven, E. Hulleman, Sieger Leenstra, Ziya L. Gokaskan, Peter Canoll, Sagar R. Shah, Henry Brem, Pieter Wesseling, Ulrike S. Trojahn, Gary L. Gallia, Ryuichi Kanai, Vafi Salmasi, Mengqing Xiang, Julia Pöschl, D.J. Brat, Stephen D. Nimer, Craig Soderquist, Lionel M. Chow, T. Lagerweij, Tiffany Doucette, Jean-Paul Wolinsky, Elena Bazzoli, Jörg-Christian Tonn, Christoph Krafft, Maureen O'Connor-McCourt, Ulrich Schüller, Andreas von Deimling, Inderjit Daphu, Rintaro Hashizume, Alessandro Olivi, Adam Sonabend, William P.J. Leenders, Lisa M. DeAngelis, Liang Lei, C.D. James, D. Noske, Cameron Brennan, Sean E. Lawler, Junyuan Zhang, B. Hamans, Corey Raffel, Jinbo Wang, Barry J. Bedell, V. Caretti, Zachary R. Barnard
Publikováno v:
Neuro-Oncology. 12:iv130-iv136
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d849b4c95f927567cbc1ec9d594ee97a
https://doi.org/10.1093/neuonc/noq116.s20
https://doi.org/10.1093/neuonc/noq116.s20
Autor:
Normand Jolicoeur, Limei Tao, Myriam Banville, Maria L. Jaramillo, Luc Meury, Maureen O’Connor McCourt.
Publikováno v:
Cancer Research. 76:1216-1216
One of the most promising and fastest growing classes of cancer therapeutics builds on the molecular targeting abilities of antibodies by combining them with drugs to generate highly specific antibody-drug conjugates (ADCs). However, the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2694cced0a0a63a6d9d281f01b28e87a
https://doi.org/10.1158/1538-7445.am2016-1216
https://doi.org/10.1158/1538-7445.am2016-1216
Autor:
Abedelnasser Abulrob, Maureen O’connor Mccourt, Zully Leon, Maria L. Jaramillo, Beatrice Paul-Roc, Suzanne Grothe
The anti-receptor antibody, 225 mAb, is known to block binding of ligand to the epidermal growth factor receptor (EGFR). However, the effect of this neutralizing antibody on EGFR endocytosis, trafficking and degradation remains unclear. Here, we demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c327a5c7c9bed9973197aedb4fd057
https://doi.org/10.1016/j.yexcr.2006.05.008
https://doi.org/10.1016/j.yexcr.2006.05.008
Autor:
Yasuhiro Nishiyama, Maureen O'Connor-McCourt, Yong Xin Zhou, Sudhir Paul, Frank C. Arnett, Meenal Sinha, Stephanie Planque
Autoantibodies to the recombinant extracellular domain of epidermal growth factor receptor (exEGFR) were detected by ELISA in the serum of Fas-defective old MRL/MpJ/lpr and C3H/HeJ/gld mice, but not young mice from these strains, or nonautoimmune you
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08bd97a6a3e3df8b0258e74830e05b2
https://doi.org/10.1096/fj.01-0847com
https://doi.org/10.1096/fj.01-0847com