Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Maureen Nerrie"'
Autor:
Lorraine K. Webster, Terrance Grant Johns, Maureen Nerrie, Andrew M. Scott, Janet Weinstock, Antony W. Burgess, Roger Murphy, Francesca Walker, G. McLachlan, Alexander Levitzki, M.M. Doherty, Angela A. Vitali, Edouard C. Nice, Andrew G. Ellis
Publikováno v:
Biochemical Pharmacology. 71:1422-1434
The tyrphostin 4-(3-chloroanilino)-6,7-dimethoxyquinazoline (AG1478) is a potent and specific inhibitor of EGFR tyrosine kinase whose favourable preclinical profile supports progression towards clinical trials. Microphysiometric evaluation revealed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef21657f946b8db43808e8e7e4e88e5
https://doi.org/10.1016/j.bcp.2006.01.020
https://doi.org/10.1016/j.bcp.2006.01.020
Autor:
Paul F. Alewood, Peter R. Andrews, Edouard C. Nice, Teresa Domagala, Sara J. White, Julie Rothacker, Francesca Walker, Maureen Nerrie, David J. Craik, Kathy Nielsen, Antony W. Burgess, Dianne Alewood
Publikováno v:
Growth Factors. 23:97-110
A systematic study using solid phase peptide synthesis has been undertaken to examine the role of the disulfide bonds in the structure and function of mEGF. A combination of one, two and three native disulfide pair analogues of an active truncated (4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edd362a9c2972d59f03ebfddaf3f9f2
https://doi.org/10.1080/08977190500096061
https://doi.org/10.1080/08977190500096061
Autor:
Otvos Lj, Maree C. Faux, Maureen Nerrie, Bruno Catimel, John D. Wade, Julie Rothacker, Antony Wilkes Burgess, E.C. Nice
Publikováno v:
The Journal of Peptide Research. 58:493-503
The coiled coil is a common structural motif found both as the dominant structure in fibrous proteins and as an oligomerization domain in a variety of cytoskeletal and extracellular matrix proteins. Coiled-coils typically consist of two to four helic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cfc8c779e6cbd3f9ff845ba809780c4
https://doi.org/10.1034/j.1399-3011.2001.10973.x
https://doi.org/10.1034/j.1399-3011.2001.10973.x
Publikováno v:
Journal of Chromatography A. 869:261-273
We have previously demonstrated the role of an optical biosensor (BIAcore 2000) as a specific detector to monitor chromatographic fractions during the purification and characterisation of ligands for orphan biomolecules. We have now extended this app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1555e98c8ee2e5ff979879a165cceb85
https://doi.org/10.1016/s0021-9673(99)01098-5
https://doi.org/10.1016/s0021-9673(99)01098-5
Autor:
Gerd Ritter, Lloyd J. Old, Andrew M. Scott, Sydney Welt, Bruno Catimel, Maureen Nerrie, Antony W. Burgess, E.C. Nice, Fook-Thean Lee
Publikováno v:
Journal of Chromatography A. 776:15-30
The interaction between the humanised A33 monoclonal antibody and the corresponding F(ab)'2 or Fab' fragments with the colonic epithelial A33 antigen, purified by micropreparative HPLC from membrane extracts of the colonic carcinoma cell line LIM 121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bb02579d583052001668bd770f17ec1
https://doi.org/10.1016/s0021-9673(97)00087-3
https://doi.org/10.1016/s0021-9673(97)00087-3
Autor:
John I. Sachinidis, Henri Tochon-Danguy, Andrew M. Scott, Uwe Ackermann, Edouard C. Nice, Maureen Nerrie
Publikováno v:
Nuclear medicine and biology. 32(4)
Four analogues of AG957, a known inhibitor of the tyrosine kinase p210 bcr-abl , have been synthesized and tested for their growth inhibitory effect against the BCR/ABL-positive FDrv210C cells as well as the epidermal growth factor (EGF) receptor-pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1009ccbfa3ce7d25ddad687955fce1
https://pubmed.ncbi.nlm.nih.gov/15878501
https://pubmed.ncbi.nlm.nih.gov/15878501
Autor:
Edouard C. Nice, Thomas P. J. Garrett, Hong-Jian Zhu, Hui-Hua Zhang, Andrew M. Scott, Antony W. Burgess, Robert N. Jorissen, Maureen Nerrie, Peter A. Hoyne, Francesca Walker, Nathan E. Hall, Timothy E. Adams, Terrance Grant Johns, Colin W. Ward, Suzanne G Orchard
Publikováno v:
The Journal of biological chemistry. 279(21)
Recent crystallographic data on the isolated extracellular domain of the epidermal growth factor receptor (EGFR) have suggested a model for its activation by ligand. We have tested this model in the context of the full-length EGFR displayed at the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959b450c4f01d038359d173ef87c28cd
https://pubmed.ncbi.nlm.nih.gov/15016810
https://pubmed.ncbi.nlm.nih.gov/15016810
Autor:
Maureen Nerrie, D F Cui, Teresa Domagala, Robert N. Jorissen, Louis Fabri, Y S Zhang, Anthony W Burgess, Francesca Walker, Edouard C. Nice
Publikováno v:
Growth factors (Chur, Switzerland). 20(2)
Epidermal Growth Factor (EGF) is a small growth factor containing 53 amino acid residues capable of stimulating the proliferation of both mesenchymal and epithelial cells. Comparison of the amino acid sequences of EGF from several species, and relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f64cac8364e5ee0e4469f86e45145d
https://pubmed.ncbi.nlm.nih.gov/12148565
https://pubmed.ncbi.nlm.nih.gov/12148565
Autor:
Julie Rothacker, T. C. Elleman, Kim M. Richards, Peter A. Hoyne, Robert N. Jorissen, Jennifer Lewis, Thomas Peter John Garrett, Colin Wesley Ward, Geoffrey J. Howlett, Teresa Domagala, Edouard C. Nice, Antony W. Burgess, Timothy E. Adams, Meizhen Lou, Björn Lönnqvist, Maureen Nerrie, George O. Lovrecz, Neil M. McKern
Publikováno v:
Biochemistry. 40(30)
Murine and human epidermal growth factor receptors (EGFRs) bind human EGF (hEGF), mouse EGF (mEGF), and human transforming growth factor alpha (hTGF-alpha) with high affinity despite the significant differences in the amino acid sequences of the liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e297fe2f14501fa69c1ac316b1a7e99
https://pubmed.ncbi.nlm.nih.gov/11467954
https://pubmed.ncbi.nlm.nih.gov/11467954
Autor:
P. Hoyne, K. Richards, C. Ward, Geoffrey J. Howlett, Antony Wilkes Burgess, J. Lewis, Julie Rothacker, Robert N. Jorissen, E.C. Nice, G. Lovrecz, T. Garrett, Teresa Domagala, T Adams, Maureen Nerrie, T. Elleman, N. McKern
Publikováno v:
Peptides: The Wave of the Future ISBN: 9789401039055
Murine and human epidermal growth factor receptors (EGFRs) bind human EGF (hEGF), mouse EGF (mEGF) and human transforming growth factor-α (h-TGF-α) with high affinity despite significant differences in the amino acid sequences of the ligands and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4fd2c5b3a276029dc6ba3b0d43708b
https://doi.org/10.1007/978-94-010-0464-0_411
https://doi.org/10.1007/978-94-010-0464-0_411
