Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Maureen N. Ajuebor"'
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38051 (2012)
Uncontrolled systemic activation of the immune system is an early initiating event that leads to development of acute fulminant liver failure (FLF) in mice after treatment with agonistic Fas mAb. In this study, we demonstrate that treatment of mice w
Externí odkaz:
https://doaj.org/article/71743af2a7d34b65bd1c7d746409d28d
Publikováno v:
Biochemical and Biophysical Research Communications. 428:245-251
Acetaminophen (APAP) overdose is widely regarded as a major cause of acute liver failure in the United States. Intentional or accidental overdose of APAP in man or rodent elicits direct hepatocellular injury that is accompanied by hepatic depletion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5f8836b5e081e17b81d597210506f7
https://doi.org/10.1016/j.bbrc.2012.10.029
https://doi.org/10.1016/j.bbrc.2012.10.029
Publikováno v:
Journal of Virology. 84:8520-8529
Replication-defective recombinant adenoviruses are the most widely studied replication-defective vectors for the potential treatment of inherited human diseases. However, broad clinical application of replication-defective adenoviruses in gene therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6dbb9bb22e06ea29654e6a9b97d4713
https://doi.org/10.1128/jvi.00605-10
https://doi.org/10.1128/jvi.00605-10
Publikováno v:
Experimental and Molecular Pathology. 86:32-35
Polyinosinic-polyctidylic acid (Poly I:C) is a viral RNA mimic that can induce immune responses similar to that seen during viral infection. Although poly I:C administration into mice is associated increased NK cell infiltrates in the liver, the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2baed5edebce767ce88ce5714eecb97e
https://doi.org/10.1016/j.yexmp.2008.10.005
https://doi.org/10.1016/j.yexmp.2008.10.005
Autor:
Maureen N. Ajuebor, G. Gremillion, Yijun Jin, Qingling Chen, Robert M. Strieter, Patrick Adegboyega
Publikováno v:
Journal of Virology. 82:9564-9576
Emerging studies suggest an important role for the innate immune response in replication-defective adenovirus (Ad)-mediated acute liver toxicity. Specifically, classical innate immune cells (including NK cells, neutrophils, and Kupffer cells) have al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2b522b2640778071c0a1bb99b36167
https://doi.org/10.1128/jvi.00927-08
https://doi.org/10.1128/jvi.00927-08
Autor:
Cory M. Hogaboam, Mark G. Swain, Amanda E. I. Proudfoot, Zenebech Wondimu, Tai Le, Maureen N. Ajuebor
Publikováno v:
The American Journal of Pathology. 170:1975-1988
Natural killer (NK) cells are innate immune cells that are enriched in the liver, but the processes underlying NK cell trafficking to the liver and cellular activation within the liver of patients with T cell-mediated liver diseases remain poorly def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2c206834a384cd85a2f31bd9075edc
https://doi.org/10.2353/ajpath.2007.060690
https://doi.org/10.2353/ajpath.2007.060690
Publikováno v:
The Journal of Immunology. 177:2039-2045
The chemokine receptor CCR5 came into worldwide prominence a decade ago when it was identified as one of the major coreceptors for HIV infectivity. However, subsequent studies suggested an important modulatory role for CCR5 in the inflammatory respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9a6ffaea20a7c68bcbdc855c6ace5a
https://doi.org/10.4049/jimmunol.177.4.2039
https://doi.org/10.4049/jimmunol.177.4.2039
Autor:
Claudine S. Bonder, Mark G. Swain, Sirpa Jalkanen, Maureen N. Ajuebor, Lori Zbytnuik, Paul Kubes, M. Ursula Norman, Pere Santamaria, Jun Yamanouchi, Marko Salmi
Publikováno v:
Immunity. 23:153-163
The mechanisms that mediate the recruitment of Th1 and Th2 lymphocytes in vivo are poorly understood. We demonstrate that the mechanisms by which exogenously produced CD4(+) Th1 and Th2 cells roll and adhere in Con A-inflamed liver microcirculation d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52081933297f746578f2114ae3245ffc
https://doi.org/10.1016/j.immuni.2005.06.007
https://doi.org/10.1016/j.immuni.2005.06.007
Autor:
Mark G. Swain, Steven M. Kerfoot, Henry Nguyen, Charlotte D'Mello, Tai Le, Paul Kubes, Maureen N. Ajuebor
Publikováno v:
Hepatology. 43:154-162
Signaling occurs between the liver and brain in cholestatic liver disease, giving rise to sickness behaviors such as fatigue. However, the signaling pathways involved are poorly defined. Circulating inflammatory mediator levels are increased in chole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a64308180622992dbf3cda81fabbd5
https://doi.org/10.1002/hep.21003
https://doi.org/10.1002/hep.21003
Publikováno v:
European Journal of Immunology. 34:2907-2918
T cell-mediated hepatitis is associated with significant morbidity and mortality worldwide. Levels of C-C chemokine ligand 3/macrophage inflammatory protein-1alpha (CCL3/MIP-1alpha) are elevated in the serum of patients with T cell-mediated liver dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd78bb650fc1560c914a3ce13bd2420
https://doi.org/10.1002/eji.200425071
https://doi.org/10.1002/eji.200425071