Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Maureen Mee"'
Autor:
Johnathan Ho, Christin Pelzel, Andreas Begitt, Maureen Mee, Hany M Elsheikha, David J Scott, Uwe Vinkemeier
Publikováno v:
PLoS Biology, Vol 14, Iss 10, p e2000117 (2016)
STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, the human and murine STAT2-deficient phenotypes suggest important additional and currently unidentified type 1 IF
Externí odkaz:
https://doaj.org/article/f2562fdce7bf4c919c2757e5572c65b6
Publikováno v:
Physiological Reports
The airway epithelium is altered in respiratory disease and is thought to contribute to disease etiology. A caveat to disease research is that the technique of isolation of bronchial epithelial cells from patients is invasive and cells have a limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357725d239f0cf9ab35c50c27f45676b
http://europepmc.org/articles/PMC5002903
http://europepmc.org/articles/PMC5002903
Autor:
Uwe Vinkemeier, Hany M. Elsheikha, Johnathan On Kay Ho, Christin Pelzel, David J. Scott, Maureen Mee, Andreas Begitt
Publikováno v:
PLoS Biology
PLoS Biology, Vol 14, Iss 10, p e2000117 (2016)
PLoS Biology, Vol 14, Iss 10, p e2000117 (2016)
STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, the human and murine STAT2-deficient phenotypes suggest important additional and currently unidentified type 1 IF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83be1af40c0e1b430a392e7a86ba5100
https://pubmed.ncbi.nlm.nih.gov/27780205
https://pubmed.ncbi.nlm.nih.gov/27780205
Publikováno v:
Neuroscience Letters. 521:130-135
The ubiquitin proteasome system (UPS) is a fundamental cellular pathway, degrading most unwanted intracellular soluble proteins. Dysfunction of the UPS has been associated with normal aging as well as various age-related pathological conditions, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785bd9163620a8bb37dfca0a6661d9a7
https://doi.org/10.1016/j.neulet.2012.05.070
https://doi.org/10.1016/j.neulet.2012.05.070
Autor:
Simon Dawson, Kelli Baalman, Khosrow Rezvani, R. John Mayer, Mariella De Biasi, Yanfen Teng, Maureen Mee, Hongmin Wang
Publikováno v:
J Neurochem
J. Neurochem. (2012) 122, 24–37. Abstract The metabotropic glutamate receptors (mGluRs) fine-tune the efficacy of synaptic transmission. This unique feature makes mGluRs potential targets for the treatment of various CNS disorders. There is ample e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462c686e5d8752b3ba24b1106f2a93fe
https://doi.org/10.1111/j.1471-4159.2012.07752.x
https://doi.org/10.1111/j.1471-4159.2012.07752.x
Autor:
Maureen Mee, Banu Iskender, Tristan R. McKay, John D. Aplin, Daniel E. Foxler, Maria V. Camarasa, Duncan Miller, Jayne C. Fitzsimmons, Susan J. Kimber, Tyson V. Sharp, Nicola Bates, Jinpei Ye, Daniel R. Brison
Publikováno v:
Stem Cell Research. 7(2):154-162
We have generated a human feeder cell line from early second trimester Placental Stromal Fibroblasts (ihPSF) stably over-expressing the polycomb protein BMI-1. These feeder cells retain the ability to maintain human Embryonic Stem cells (hESc) over l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18137533171b79b1c90fd4f1e504f6b2
Publikováno v:
Autophagy. 5:224-227
In the past twenty years, evidence has accumulated to show that ubiquitinated proteins are a consistent feature of the intraneuronal protein aggregates (inclusions) that characterize chronic neurodegenerative disease. These findings may indicate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d21b986b2eab8f04b491cf650015f4
https://doi.org/10.4161/auto.5.2.7389
https://doi.org/10.4161/auto.5.2.7389
Autor:
David Hay, Lynn Bedford, Simon M. L. Paine, Nooshin Rezvani, R. John Mayer, Maureen Mee, James Lowe
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1782:683-690
Neuropathological investigations have identified major hallmarks of chronic neurodegenerative disease. These include protein aggregates called Lewy bodies in dementia with Lewy bodies and Parkinson's disease. Mutations in the α-synuclein gene have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f21252c51d5e2e3e88772a88e35c2a
https://doi.org/10.1016/j.bbadis.2008.10.009
https://doi.org/10.1016/j.bbadis.2008.10.009
Autor:
Dumitru Constantin-Teodosiu, Sophie Drinkwater, Maureen Mee, Giulio Podda, Guang-Xian Zhang, Cris S. Constantinescu, Bruno Gran, Amit Bar-Or, Uwe Vinkemeier, Mukanthu Nyirenda, Lloyd King, Amir M. Ghaemmaghami, Elena Morandi
CD4+CD25hi FOXP3+ regulatory T cells (Tregs) maintain tolerance to self-Ags. Their defective function is involved in the pathogenesis of multiple sclerosis (MS), an inflammatory demyelinating disease of the CNS. However, the mechanisms of such defect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850daac63273edd1a4176acccfa94dc8
http://eprints.nottingham.ac.uk/35716/
http://eprints.nottingham.ac.uk/35716/
Autor:
Tyson V. Sharp, Gregory D. Longmore, Sigurdur Ingvarsson, Yunfeng Feng, Dumitru Constantin-Teodosiu, Peter J. Ratcliffe, Johannes Bjornsson, Maureen Mee, Victoria James, Sybil C.K. Wong, Thomas M. Webb, Daniel E. Foxler, Katherine S. Bridge, Thorgunnur Eyfjord Petursdottir
Publisher's version (útgefin grein)
There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O(2) tension. In high O(2
There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O(2) tension. In high O(2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c11c7d6fb2357b455c3d22dba5f85d
https://hdl.handle.net/20.500.11815/1344
https://hdl.handle.net/20.500.11815/1344