Regulation of T-cell receptor beta-chain gene assembly by recombination signals: the beyond 12/23 restriction

Autor: Barry P. Sleckman, Robert E. Tillman, Maureen M. Hughes, Bernard Khor, Andrea L. Wooley

Publikováno v: Immunological reviews. 200

Assembly of antigen receptor genes is regulated in several important contexts during lymphocyte development. This regulation occurs through modulation of gene segment accessibility to the V(D)J recombinase and/or at the level of the recombination rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de577f28f84c19d8d62165304569e7a
https://pubmed.ncbi.nlm.nih.gov/15242394

T cell receptor CDR3 loop length repertoire is determined primarily by features of the V(D)J recombination reaction

Autor: Tara D. Wehrly, Osami Kanagawa, Ching-Yu Huang, Barry P. Sleckman, Maureen M. Hughes, Maryam Yassai, John R. Sedy, Jack Gorski

Publikováno v: European journal of immunology. 33(6)

The third complementarity-determining region (CDR) of the TCR alpha and beta chains forms loops that engage amino acid residues of peptides complexed with MHC. This interaction is central to the specific discrimination of antigenic-peptide-MHC comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bffa37ffa026ecc054a7fcf930c3419
https://pubmed.ncbi.nlm.nih.gov/12778474

Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule

Autor: D'Auteuil M, Frederick W. Alt, Craig H. Bassing, Woodman Bb, Maureen M. Hughes, Frank Gärtner, Laurie Davidson, Tara D. Wehrly, Barry P. Sleckman, White Jm

Publikováno v: Nature. 405(6786)

The genes encoding the variable regions of lymphocyte antigen receptors are assembled from variable (V), diversity (D) and joining (J) gene segments. V(D)J recombination is initiated by the recombinase activating gene (RAG)-1 and -2 proteins, which i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d8b830fdf48b49aff9c81b626825ba
https://pubmed.ncbi.nlm.nih.gov/10850719

Ion-exchange chromatography followed by ESI-MS for quantitative analysis of sugar monophosphates from glucose catabolism.

Autor: Walters JJ; Department of Chemistry, Washington University, One Brookings Drive, Campus Box 1134, 63130, St. Louis, MO, USA.; the Department of Chemistry and Biochemistry, University of Missouri, 63121, St. Louis, MO., Grayson MA; Department of Chemistry, Washington University, One Brookings Drive, Campus Box 1134, 63130, St. Louis, MO, USA., Gross ML; Department of Chemistry, Washington University, One Brookings Drive, Campus Box 1134, 63130, St. Louis, MO, USA. mgross@wustl.edu., Hughes M; Department of Biology, Washington University, St. Louis, Missouri, USA., Shearer G; Department of Biology, Washington University, St. Louis, Missouri, USA., Kohl DH; Department of Biology, Washington University, St. Louis, Missouri, USA., Bashkin J; Department of Chemistry and Biochemistry, University of Missouri, St. Louis, Missouri, USA.

Publikováno v: Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2006 Jan; Vol. 17 (1), pp. 104-107. Date of Electronic Publication: 2005 Dec 15.