Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maureen M Mundia"'
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36821 (2012)
Determining the molecular mechanisms that lead to the development of heart failure will help us gain better insight into the most costly health problem in the Western world. To understand the roles that the actin protein plays in the development of h
Externí odkaz:
https://doaj.org/article/8f342a7da295465da3f0ee814b7db858
Publikováno v:
DNA Repair. 88:102805
This study was initiated to examine the effects of caffeine on the DNA damage response (DDR) and homologous recombination (HR) in mammalian cells. A 5 mM caffeine treatment caused the cell cycle to stall at G2/M and cells eventually underwent apoptos
Autor:
Maureen M. Mundia, Michael J. Malysewich, Iulia Cealic, Jennifer Knapp, Alissa C. Magwood, Mark D. Baker
Publikováno v:
DNA Repair. 12:1122-1133
Stable expression of Rad51 siRNA was used to generate mouse hybridoma cell lines in which endogenous Rad51 levels were depleted by as much as 60%. Stable Rad51 knockdowns feature reduced homologous recombination responses. The relative ease with whic
This study was initiated to examine the effects of caffeine on the DNA damage response (DDR) and homologous recombination (HR). An initial 2 h exposure to 5 mM caffeine slowed a fraction of the cells in G1, but thereafter, continued caffeine exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb697be0fe337fbcdf6c6cc4bd8d9b6
In this study, we utilized mouse hybridoma cell lines stably expressing ectopic wild-type Rad51, or the Rad51-K133A and Rad51-K133R catalytic mutants deficient in ATP binding and ATP hydrolysis, respectively, to investigate effects on the Rad51 nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b3e7fe25354547b3d171a4346fe04f
https://doi.org/10.1101/070276
https://doi.org/10.1101/070276
Publikováno v:
Journal of Molecular Biology. 421:38-53
Endogenous levels of the BRCA2 (breast cancer susceptibility 2) protein promote homologous recombination by regulating the essential strand exchange protein RAD51. To examine BRCA2 function in homologous recombination, we expressed human BRCA2 in con
Autor:
Maureen M. Mundia, Mark D. Baker, Weiduo Si, Richard D. McCulloch, Alissa C. Magwood, Adam L. Mark
Publikováno v:
Genetics. 185:443-457
Initial events in double-strand break repair by homologous recombination in vivo involve homology searching, 3′ strand invasion, and new DNA synthesis. While studies in yeast have contributed much to our knowledge of these processes, in comparison,
Autor:
John F. Dawson, Fangliang Zhang, Sougata Saha, Maureen M. Mundia, Ryan W. Demers, Tatyana Svitkina, Alex A. PerieteanuA.A. Perieteanu, Farida Korobova, Anna Kashina
Publikováno v:
Molecular Biology of the Cell
Actin arginylation regulates lamella formation in motile fibroblasts, but the underlying molecular mechanisms are unknown. Here, we found that actin regulation by arginylation affects its biochemical properties and binding of actin-associated protein