Výsledky vyhledávání - "Maureen M Barr"

Akademický článek

Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles.

Autor: Jonathon D Walsh, Juan Wang, Molly DeHart, Inna A Nikonorova, Jagan Srinivasan, Maureen M Barr

Publikováno v: PLoS Genetics, Vol 18, Iss 12, p e1010560 (2022)

The cilium acts as an antenna receiving and sending signals, the latter via extracellular vesicles (EVs). In C. elegans and mammals, the Autosomal Dominant Polycystic Kidney Disease (ADPKD) gene products polycystin-1 (PC1) and polycystin-2 (PC2) loca

Externí odkaz: https://doaj.org/article/4c305ba884dc44868391692cdd220c41

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Akademický článek

Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.

Autor: Kade M Power, Jyothi S Akella, Amanda Gu, Jonathon D Walsh, Sebastian Bellotti, Margaret Morash, Winnie Zhang, Yasmin H Ramadan, Nicole Ross, Andy Golden, Harold E Smith, Maureen M Barr, Robert O'Hagan

Publikováno v: PLoS Genetics, Vol 16, Iss 10, p e1009052 (2020)

Ciliary microtubules are subject to post-translational modifications that act as a "Tubulin Code" to regulate motor traffic, binding proteins and stability. In humans, loss of CCP1, a cytosolic carboxypeptidase and tubulin deglutamylating enzyme, cau

Externí odkaz: https://doaj.org/article/c31953d4b8684ae9b72f982eed9b6462

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Akademický článek

Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding

Autor: Jyothi S Akella, Stephen P Carter, Ken Nguyen, Sofia Tsiropoulou, Ailis L Moran, Malan Silva, Fatima Rizvi, Breandan N Kennedy, David H Hall, Maureen M Barr, Oliver E Blacque

Publikováno v: eLife, Vol 9 (2020)

Cilia both receive and send information, the latter in the form of extracellular vesicles (EVs). EVs are nano-communication devices that influence cell, tissue, and organism behavior. Mechanisms driving ciliary EV biogenesis are almost entirely unkno

Externí odkaz: https://doaj.org/article/255a9f0af14d40348773432bb55495c4

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Akademický článek

Middle Age Has Its Advantages.

Autor: Maureen M Barr

Publikováno v: PLoS Genetics, Vol 12, Iss 12, p e1006426 (2016)

Externí odkaz: https://doaj.org/article/8c5d4acfcf784fbab2742e3f229af9a3

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Akademický článek

SID-2 is a conserved extracellular vesicle protein that is not associated with environmental RNAi in parasitic nematodes

Autor: Frances Blow, Kate Jeffrey, Franklin Wang-Ngai Chow, Inna A. Nikonorova, Maureen M. Barr, Atlanta G. Cook, Bram Prevo, Dhanya K. Cheerambathur, Amy H. Buck

Publikováno v: Open Biology, Vol 14, Iss 11 (2024)

In the free-living nematode Caenorhabditis elegans, the transmembrane protein SID-2 imports double-stranded RNA into intestinal cells to trigger systemic RNA interference (RNAi), allowing organisms to sense and respond to environmental cues such as t

Externí odkaz: https://doaj.org/article/18b76df2d4cb4bd18d50b00e8cbcaeb3

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Akademický článek

The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans.

Autor: Simon R F Warburton-Pitt, Malan Silva, Ken C Q Nguyen, David H Hall, Maureen M Barr

Publikováno v: PLoS Genetics, Vol 10, Iss 12, p e1004866 (2014)

Cilia are microtubule-based cellular organelles that mediate signal transduction. Cilia are organized into several structurally and functionally distinct compartments: the basal body, the transition zone (TZ), and the cilia shaft. In vertebrates, the

Externí odkaz: https://doaj.org/article/ec304061f42e402eb146394bb9491674

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Akademický článek

Tomography gives a new dimension to an ancient organelle

Autor: Malan Silva, Maureen M Barr

Publikováno v: eLife, Vol 3 (2014)

Advances in sample preparation and electron microscopy have allowed the structure of cilia to be explored at an unprecedented level of detail.

Externí odkaz: https://doaj.org/article/3e336bb7013f463d993704c506b928b9

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The tubulin code specializes neuronal cilia for extracellular vesicle release

Autor: Jyothi S. Akella, Maureen M. Barr

Publikováno v: Dev Neurobiol

Cilia are microtubule-based organelles that display diversity in morphology, ultrastructure, protein composition, and function. The ciliary microtubules of C. elegans sensory neurons exemplify this diversity and provide a paradigm to understand mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1130f92b0bb59c43cf27cb9252f88e4f
https://doi.org/10.1002/dneu.22787

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What about the males? the C. elegans sexually dimorphic nervous system and a CRISPR-based tool to study males in a hermaphroditic species

Autor: Olivier Boivin, Maureen M. Barr, Jonathon D. Walsh

Publikováno v: Journal of Neurogenetics. 34:323-334

Sexual dimorphism is a device that supports genetic diversity while providing selective pressure against speciation. This phenomenon is at the core of sexually reproducing organisms. Caenorhabditis elegans provides a unique experimental system where

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ada02186ed467fd6cdddf2b9c1f84bca
https://doi.org/10.1080/01677063.2020.1789978

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