Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maureen L. Sampson"'
Autor:
Erwin Garcia, Irina Shalaurova, Steven P. Matyus, Lita A. Freeman, Edward B. Neufeld, Maureen L. Sampson, Rafael Zubirán, Anna Wolska, Alan T. Remaley, James D. Otvos, Margery A. Connelly
Publikováno v:
Molecules, Vol 29, Iss 3, p 564 (2024)
Lipoprotein X (LP-X) is an abnormal cholesterol-rich lipoprotein particle that accumulates in patients with cholestatic liver disease and familial lecithin–cholesterol acyltransferase deficiency (FLD). Because there are no high-throughput diagnosti
Externí odkaz:
https://doaj.org/article/7b4075c84b5d4606bf457aaea0b6e7e5
Autor:
Masaki Sato, Edward B. Neufeld, Martin P. Playford, Yu Lei, Alexander V. Sorokin, Angel M. Aponte, Lita A. Freeman, Scott M. Gordon, Amit K. Dey, Kianoush Jeiran, Masato Hamasaki, Maureen L. Sampson, Robert D. Shamburek, Jingrong Tang, Marcus Y. Chen, Kazuhiko Kotani, Josephine L.C. Anderson, Robin P.F. Dullaart, Nehal N. Mehta, Uwe J.F. Tietge, Alan T. Remaley
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
BACKGROUND Cellular cholesterol efflux capacity (CEC) is a better predictor of cardiovascular disease (CVD) events than HDL-cholesterol (HDL-C) but is not suitable as a routine clinical assay.METHODS We developed an HDL-specific phospholipid efflux (
Externí odkaz:
https://doaj.org/article/39566e9a46204437a84f2a721f256ea3
Autor:
Edward B. Neufeld, Lita A. Freeman, Vinay Durbhakula, Maureen L. Sampson, Robert D. Shamburek, Sotirios K. Karathanasis, Alan T. Remaley
Publikováno v:
Biology, Vol 11, Iss 8, p 1248 (2022)
Lipoprotein-X (LpX) are abnormal nephrotoxic lipoprotein particles enriched in free cholesterol and phospholipids. LpX with distinctive lipid compositions are formed in patients afflicted with either familial LCAT deficiency (FLD) or biliary cholesta
Externí odkaz:
https://doaj.org/article/6ed159cc775c49b792a6b85b47d79cc8
Autor:
Stephanie T. Chung, Samantha T. Matta, Abby G. Meyers, Celeste K. Cravalho, Alfredo Villalobos-Perez, Joshua M. Dawson, Vandhna R. Sharma, Maureen L. Sampson, James D. Otvos, Sheela N. Magge
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Youth with obesity have an increased risk for cardiometabolic disease, but identifying those at highest risk remains a challenge. Four biomarkers that might serve this purpose are “by products” of clinical NMR LipoProfile® lipid testing: LPIR (L
Externí odkaz:
https://doaj.org/article/e8ecf3253df94b1f91626b99a368a0fc
Autor:
Lita A. Freeman, Robert D. Shamburek, Maureen L. Sampson, Edward B. Neufeld, Masaki Sato, Sotirios K. Karathanasis, Alan T. Remaley
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 1050-1057 (2019)
Familial LCAT deficiency (FLD) patients accumulate lipoprotein-X (LP-X), an abnormal nephrotoxic lipoprotein enriched in free cholesterol (FC). The low neutral lipid content of LP-X limits the ability to detect it after separation by lipoprotein elec
Externí odkaz:
https://doaj.org/article/334e3aea938c4fc9b998b97c64d7fd77
Autor:
Marcelo J. A. Amar, Lita A. Freeman, Takafumi Nishida, Maureen L. Sampson, Milton Pryor, Boris L. Vaisman, Edward B. Neufeld, Sotirios K. Karathanasis, Alan T. Remaley
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract Familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare genetic disease characterized by low HDL‐C levels, low plasma cholesterol esterification, and the formation of Lipoprotein‐X (Lp‐X), an abnormal cholestero
Externí odkaz:
https://doaj.org/article/a5400b9886c54798acd3bec096f0c038
Autor:
Amisha V. Barochia, Elizabeth M. Gordon, Maryann Kaler, Rosemarie A. Cuento, Patricia Theard, Debbie M. Figueroa, Xianglan Yao, Nargues A. Weir, Maureen L. Sampson, Mario Stylianou, David F. Choy, Cecile T.J. Holweg, Alan T. Remaley, Stewart J. Levine
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 8, Pp 1713-1721 (2017)
Blood eosinophil counts and serum periostin levels are biomarkers of type 2 inflammation. Although serum levels of HDL and apoA-I have been associated with less severe airflow obstruction in asthma, it is not known whether serum lipids or lipoprotein
Externí odkaz:
https://doaj.org/article/e258bc5868a040d483df2edbffce33b4
Autor:
Boris L. Vaisman, Stephen J. Demosky, John A. Stonik, Mona Ghias, Cathy L. Knapper, Maureen L. Sampson, Cuilian Dai, Stewart J. Levine, Alan T. Remaley
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 1, Pp 158-167 (2012)
The role of endothelial ABCA1 expression in reverse cholesterol transport (RCT) was examined in transgenic mice, using the endothelial-specific Tie2 promoter. Human ABCA1 (hABCA1) was significantly expressed in endothelial cells (EC) of most tissues
Externí odkaz:
https://doaj.org/article/3e498bf85dcc419e86568cfc3a40685b
Autor:
Sara Fernández-Castillejo, Rosa-Maria Valls, Olga Castañer, Laura Rubió, Úrsula Catalán, Anna Pedret, Alba Macià, Maureen L. Sampson, María-Isabel Covas, Montserrat Fitó, Maria-José Motilva, Alan T. Remaley, Rosa Solà
Publikováno v:
Molecular Nutrition & Food Research. 60
Autor:
Boris Vaisman, Xavier Rousset, Bruce J Auerbach, Brian R Krause, Reyn Homan, Lita Freeman, Alice Ossoli, Maureen L Sampson, Alan Remaley
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33
BACKGROUND LCAT, an enzyme that converts small, discoidal HDL to spherical HDL particles by esterifying free cholesterol, plays a key role in reverse cholesterol transport (RCT). LCAT replacement therapy holds promise for treatment of familial LCAT d