Výsledky vyhledávání - "Maureen Kay Reilly"

Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors

Publikováno v: Journal of Medicinal Chemistry. 63:8584-8607

The C-C chemokine receptor 4 (CCR4) is broadly expressed on regulatory T cells (Treg) as well as other circulating and tissue-resident T cells. Treg can be recruited to the tumor microenvironment (TME) through the C-C chemokines CCL17 and CCL22. Treg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff8f25af0448a07583421b7d8d0bfa7
https://doi.org/10.1021/acs.jmedchem.0c00988

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Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment

Publikováno v: Journal of Medicinal Chemistry. 62:6190-6213

Recruitment of suppressive CD4+ FOXP3+ regulatory T cells (Treg) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in patients receiving treatment with immuno-oncology (IO) agents. Human Treg express CCR4 and can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31c664d1b35dae60b88d59898f44ef53
https://doi.org/10.1021/acs.jmedchem.9b00506

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Abstract 4752: EBV associated tumors have increased regulatory T cell recruitment and are therefore a potential indication for treatment with potent and selective small molecule CCR4 antagonists

Autor: Maureen Kay Reilly, John M. Ketcham, Omar Robles, Aparna Jorapur, Sachie Marubayashi, Silpa Suthram, Oezcan Talay, Jacob Bradley Schwarz, Berenger Biannic, Minna Bui, Gene Cutler, Paul D. Kassner, Lisa A. Marshall, Ashkaan Younai, Dennis X. Hu, Scott Jacobson

Publikováno v: Cancer Research. 78:4752-4752

We have performed experiments to test whether Epstein Barr Virus (EBV)-infected tumors are enhanced for regulatory T cell (Treg) infiltration and whether selective and potent CCR4 antagonists would be a particularly effective therapeutic in this clas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b9af018744f081116a8d614601674dc
https://doi.org/10.1158/1538-7445.am2018-4752

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Abstract 4600: Potent and selective C-C chemokine receptor (CCR4) antagonists potentiate anti-tumor immune responses by inhibiting regulatory T cells (Treg)

Autor: Lisa Seitz, Omar Robles, Abood Okal, Erin Riegler, Emily Karbaz, Scott Jacobson, Jenny McKinnell, Angela Wadsworth, Oezcan Talay, Paul D. Kassner, Lisa A. Marshall, David Chian, David J. Wustrow, Maureen Kay Reilly, Mikhail Zibisky, Cesar Meleza, Jordan S. Fridman

Publikováno v: Cancer Research. 77:4600-4600

Naturally suppressive CD4+ Foxp3+ Treg are essential for immune tolerance. Although Treg-mediated suppression of effector cells is important to control inflammation and prevent autoimmune diseases, the presence of Treg in the tumor microenvironment (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3b87bf475ea463f95dd6cca5fc91857
https://doi.org/10.1158/1538-7445.am2017-4600

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Abstract 4290: Potent and selective next generation inhibitors of indoleamine-2,3-dioxygenase (IDO1) for the treatment of cancer

Autor: Jan Melom, Mikhail Zibinsky, Nick Shah, Hunter P. Shunatona, Maureen Kay Reilly, Jenny McKinnell, Jordan S. Fridman, Jay P. Powers, Pia Bjork, Juan C. Jaen, Hilary Plake Beck, James Ross Walker, Maksim Osipov, Adam Park, Matthew J. Walters, Rajkumar Noubade, David Chian, Stephen W. Young, Lisa A. Marshall

Publikováno v: Cancer Research. 75:4290-4290

The IDO1 pathway has been proposed to mediate immunosuppressive effects in the tumor microenvironment through its role in the catabolism of tryptophan, resulting in effects on the differentiation and proliferation of T cells. IDO1 inhibition has show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc74ef9a042ad4b047fa624f482da031
https://doi.org/10.1158/1538-7445.am2015-4290

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