Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Maureen K. Anderson"'
Autor:
Reynold Homan, Jon A. Story, Robert E. Porter, Kimberly K. Buhman, Robert G. Elkin, Yuan Zhong, John J. Turek, Roger S. Newton, Maureen K. Anderson, Zhihong Yan, Shawn S. Donkin
Publikováno v:
The Journal of Nutrition. 129:1010-1019
The inability to markedly attenuate cholesterol levels in chicken eggs has led to speculation that cholesterol is essential for yolk formation and that egg production would cease when yolk cholesterol deposition was inadequate for embryonic survival.
Publikováno v:
Lipids. 33:489-498
WAY-121,898 is an inhibitor of pancreatic cholesteryl ester hydrolase (pCEH). After confirming its in vitro potency and relative lack of a major effect on acyl-CoA:cholesterol acyltransferase (ACAT), it was found that this compound lowers plasma chol
Autor:
Reynold Homan, Maureen K. Anderson
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 708:21-26
Modifications are described for an innovative and widely used high-performance liquid chromatography technique that resolves a very broad spectrum of lipids for quantitation by evaporative light-scattering detection. Substitution of acetone for 2-pro
Autor:
Maureen K. Anderson, Andrew D. White, Thomas M.A. Bocan, R. F. Bousley, Claude Forsey Purchase, Sandra Bak Mueller, Brian R. Krause, Peter Lee, J. F. Reindel, Reynold Homan, R. L. Stanfield, K. L. Hamelehle, Cecilia Speyer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1753-1758
A novel series of tetrazole-substituted ureas 2 were prepared from weakly nucleophilic amines using a new coupling method. The ureas were found to potently inhibit liver ACAT in vitro and lower total serum cholesterol in vivo. A comparison of urea 2b
Autor:
Maureen K. Anderson, Patrice Lee, J. F. Reindel, K. L. Hamelehle, R. L. Stanfield, Drago Sliskovic, J. A. Picard, Bruce D. Roth, B.R. Krause, D. Turluck, Andrew D. White, Sandra Bak Mueller, Reynold Homan, Thomas M.A. Bocan, Patrick Michael O'brien, Helen Tsenwhei Lee, Claude Forsey Purchase, R. F. Bousley
Publikováno v:
Journal of Medicinal Chemistry. 39:2354-2366
A series of tetrazole amide derivatives of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide (1) was prepared and evaluated for their ability to inhibit acyl-CoA: cholesterol O-acyltransferase (ACAT) in vitro and to lo
Autor:
Maureen K. Anderson, Reynold Homan, Joseph Armand Picard, R. L. Stanfield, Bruce D. Roth, Brian R. Krause, K. L. Hamelehle, W. Howard Roark, R. F. Bousley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2367-2370
A series of sulfonylureas were prepared and tested for the ability to inhibit the enzyme acyl-CoA: cholesterol acyltransferase (ACAT) in vitro and lower plasma cholesterol in cholesterol-fed rats in vivo. Although compounds from this series were gene
Autor:
Timothy R. Hurley, R. L. Stanfield, Maureen K. Anderson, Brian R. Krause, Drago Robert Sliskovic, Adele Bernabei, Patrick Michael O'brien, R. F. Bousley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:295-300
The syntheses and biological activities for anilides derived from 2-phenyl-2-(dodecyl-2H-tetrazol-5-yl)acetic acid are described. Evidence is provided that one of these compounds, (+)- 8b , stereoselectively inhibits ACAT in vitro and possesses super
Autor:
Brian R. Krause, Maureen K. Anderson, R. L. Stanfield, R. F. Bousley, Drago Robert Sliskovic, Patrick Michael O'brien
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:289-294
The identification of tetrazole benzamide and nicotinamide derivatives as new structural classes of potent ACAT inhibitors is described. The ensuing structure-activity relationship (SAR) studies revealed that retroamide 8c and 7q possesses comparable
Autor:
Brian R. Krause, K. L. Hamelehle, Charles L. Bisgaier, A. D. Essenburg, K.A. Kieft, Thomas M.A. Bocan, Reynold Homan, Peter D. DeHart, Maureen K. Anderson, R. F. Bousley
Publikováno v:
Journal of Lipid Research, Vol 34, Iss 2, Pp 279-294 (1993)
CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A:cholesterol acyltransferase (ACAT) in vitro. Several in vivo approaches were used to determine the efficacy and sites of action of
Autor:
R. L. Stanfield, R. F. Bousley, Patrick Michael O'brien, Brian R. Krause, Drago Robert Sliskovic, Maureen K. Anderson
Publikováno v:
ChemInform. 26