Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression

Autor: Jessica M. Silva-Fisher, Ha X. Dang, Nicole M. White, Matthew S. Strand, Bradley A. Krasnick, Emily B. Rozycki, Gejae G. L. Jeffers, Julie G. Grossman, Maureen K. Highkin, Cynthia Tang, Christopher R. Cabanski, Abdallah Eteleeb, Jacqueline Mudd, S. Peter Goedegebuure, Jingqin Luo, Elaine R. Mardis, Richard K. Wilson, Timothy J. Ley, Albert C. Lockhart, Ryan C. Fields, Christopher A. Maher

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

The role of long non-coding RNAs (lncRNAs) in metastatic colorectal cancer (mCRC) and treatment resistance is unclear. Here, the authors use transcriptome sequencing of matched normal, primary, and metastatic CRC tissues to discover and validate that

Externí odkaz: https://doaj.org/article/419e0097c4524d55a96202eb846d0823

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

Autor: Michelle Kraus, Jay M. Wendling, Olga V. Nemirovskiy, John W. Rains, Vincent Peterkin, Laura E. Zawadzke, Hideji Fujiwara, Ciarán N. Cronin, Troii Hall, Tom Kasten, Maureen K. Highkin, Gina M. Jerome, Arthur J. Wittwer, Matthew P. Yates, Shinji Ogawa, Jeffrey A. Scholten, Jill Chrencik, Marek M. Nagiec, Matthew D. McReynolds, Kaliapan Iyanar, Mark E. Schnute, Kristin Cukyne, Matthew J. Saabye, Richard M. Broadus

Publikováno v: Biochemical Journal. 444:79-88

SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c29039f87435103ee01d57e1663842f
https://doi.org/10.1042/bj20111929

Synthesis of Potent Leukotriene A4 Hydrolase Inhibitors. Identification of 3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid

Autor: Walter G. Smith, Suzanne H Kim, Doreen Villani-Price, Matthew W Mahoney, Nayereh S Ghoreishi-Haack, Helen Y. Chen, Thomas D. Penning, Stella Siu-Tzyy Yu, James W. Malecha, Leslie J Askonas, Chi-Dean Liang, Elizabeth I Harding, E.Yvonne Pyla, Maureen K Highkin, James K. Gierse, Julie M Miyashiro, Mark A Russell, James F Kachur, Chen Barbara B

Publikováno v: Journal of Medicinal Chemistry. 45:3482-3490

Leukotriene B(4) (LTB(4)) is a potent, proinflammatory mediator involved in the pathogenesis of a number of diseases including inflammatory bowel disease, psoriasis, rheumatoid arthritis, and asthma. The enzyme LTA(4) hydrolase represents an attracti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49aaaeb42023ad7fd78de02ecc724a97
https://doi.org/10.1021/jm0200916

Characterization of nitrotyrosine as a biomarker for arthritis and joint injury

Autor: O. Friese, M. Abrams, D. Roman, Candace Bramson, Thomas P. Misko, M.-P. Hellio Le Graverand, L.S. Lohmander, Melissa R. Radabaugh, Maureen K. Highkin, R. Gallavan

Publikováno v: Osteoarthritis and Cartilage; 21(1), pp 151-156 (2013)
Misko, T P, Radabaugh, M R, Highkin, M, Abrams, M, Friese, O, Gallavan, R, Bramson, C, Hellio Le Graverand, M P, Lohmander, S & Roman, D 2013, ' Characterization of nitrotyrosine as a biomarker for arthritis and joint injury ', Osteoarthritis and Cartilage, vol. 21, no. 1, pp. 151-156 . https://doi.org/10.1016/j.joca.2012.09.005

Objectives: To characterize the utility of nitrotyrosine (NT) as a biomarker for arthritis and joint injury. Design: Synovial fluid, plasma, and urine from patients diagnosed with osteoarthritis (OA), rheumatoid arthritis (RA), anterior cruciate liga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9bb06451dd20cbef6c5c4d01efabe29
https://lup.lub.lu.se/record/3590089

Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase

Autor: Maureen K Highkin, Leslie J Askonas, Doreen Villani-Price, Chi-Dean Liang, Bipin N Desai, Thomas D. Penning, James F Kachur, Elizabeth I Harding, Nayereh S Ghoreishi-Haack, Mark A Russell, Julie M Miyashiro, Walter G. Smith, E.Yvonne Pyla, Nizal S Chandrakumar, Stevan W Djuric, Suzanne H Kim, James K. Gierse, Alan F. Gasiecki

Publikováno v: Bioorganicmedicinal chemistry letters. 12(23)

The synthesis and biological evaluation of a series of functionalized pyrrolidine- and piperidine-containing analogues of our lead LTA(4) hydrolase inhibitor, SC-57461A, is described. A number of compounds showed excellent potency in our in vitro scr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bec3c88d96d40830db918a67cb8307f
https://pubmed.ncbi.nlm.nih.gov/12419366