Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maureen J. Koslowski"'
Autor:
Maureen J Koslowski, Zora Teltschik, Julia Beisner, Elke Schaeffeler, Guoxing Wang, Irmgard Kübler, Michael Gersemann, Rachel Cooney, Derek Jewell, Walter Reinisch, Séverine Vermeire, Paul Rutgeerts, Matthias Schwab, Eduard F Stange, Jan Wehkamp
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002523 (2012)
Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the antimicrobial peptides DEFA5 (HD-5) and DEFA6 (HD-6). Both of these α-defensins are exclusively produced in Paneth cells (PCs) at
Externí odkaz:
https://doaj.org/article/56702dae105843a4a2280f10511cdf3f
Autor:
Maureen J Koslowski, Irmgard Kübler, Mathias Chamaillard, Elke Schaeffeler, Walter Reinisch, Guoxing Wang, Julia Beisner, Alexander Teml, Laurent Peyrin-Biroulet, Stefan Winter, Klaus R Herrlinger, Paul Rutgeerts, Séverine Vermeire, Rachel Cooney, Klaus Fellermann, Derek Jewell, Charles L Bevins, Matthias Schwab, Eduard F Stange, Jan Wehkamp
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4496 (2009)
Reduced expression of Paneth cell antimicrobial alpha-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum. TCF-4 (also named TCF7L2), a Wnt signalling pathway transcription factor, orchestrates Paneth cell differe
Externí odkaz:
https://doaj.org/article/6837cf568a854f24b2bbe8a2472f4905
Autor:
Christian Schäfer, K. Saigenji, Jan Wehkamp, Guoxing Wang, Eduard F. Stange, Maureen J. Koslowski, Miriam Schlee, Sabine Nuding, Yoshio Hosaka
Publikováno v:
European Journal of Gastroenterology & Hepatology. 20:1151-1158
BACKGROUND With the exception of fungi, microbial infections are rare in the oesophagus. Herein, we aimed to systematically assess the distribution and quantity of different antimicrobial host factors as well as, for the first time, functional mucosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a95a3b0d88e83f5aae3b6f19b63b69
https://doi.org/10.1097/meg.0b013e3283052ddb
https://doi.org/10.1097/meg.0b013e3283052ddb
Autor:
Maureen J. Koslowski, Lars Gustav Lyckander, Morten H. Vatn, Eduard F. Stange, Jan Wehkamp, Julia Beisner, Gøri Perminow
Publikováno v:
The American journal of gastroenterology. 105(2)
OBJECTIVES Adult ileal Crohn's disease (CD) is characterized by a specific decrease in ileal Paneth cell alpha-defensins. In addition to NOD2, we previously identified a disturbance of the Wnt-signaling transcription factor TCF-4 as a major mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5644b4c6c7625b346f0da961106cbc3e
https://pubmed.ncbi.nlm.nih.gov/19904243
https://pubmed.ncbi.nlm.nih.gov/19904243
Publikováno v:
International journal of medical microbiology : IJMM. 300(1)
Paneth cells (PCs) are specialized epithelial cells predominantly found in the small intestinal crypts of Lieberkuehn. They produce different broad spectrum antimicrobial peptides most abundantly the α-defensins HD-5 and -6 (DEFA5 und DEFA6). Both t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610e3384e58950b00a2c4b55fe8711ea
https://pubmed.ncbi.nlm.nih.gov/19850516
https://pubmed.ncbi.nlm.nih.gov/19850516
Autor:
Irmgard Kübler, Michael Gersemann, Svetlana Becker, Julia Beisner, K Rothfuss, Klaus Herrlinger, Klaus Fellermann, Eduard F. Stange, Jan Wehkamp, Maureen J. Koslowski
Publikováno v:
Alimentary pharmacologytherapeutics. 30(6)
Summary Background Crohn’s Disease (CD), a chronic intestinal inflammation, is currently treated primarily by therapeutics which are directed against inflammatory responses. Recent findings though suggest a central role of the innate immune barrier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61de31fa45c32d9e71cda9e9b3f38c6
https://pubmed.ncbi.nlm.nih.gov/19549264
https://pubmed.ncbi.nlm.nih.gov/19549264
Autor:
Guoxing Wang, Maureen J. Koslowski, Peter Fritz, Matthias Schwab, Klaus Fellermann, Svetlana Becker, Jan Wehkamp, Irmgard Kübler, Klaus Herrlinger, Eduard F. Stange, Michael Gersemann, Joscha Griger
Publikováno v:
Differentiation; research in biological diversity. 77(1)
Goblet cells are mucin-secreting intestinal cells forming the mucus layer that protects the mucosal surface. Ulcerative colitis (UC) has been associated with a defective colonic mucus layer and a reduced number of goblet cells. In experimental animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955d4c929ced6115cd18bb59d145acc2
https://pubmed.ncbi.nlm.nih.gov/19281767
https://pubmed.ncbi.nlm.nih.gov/19281767
Autor:
Derek P. Jewell, Guoxing Wang, Maureen J. Koslowski, Matthias Schwab, Rachel Cooney, Julia Beisner, Elke Schaeffeler, Zora Teltschik, Eduard F. Stange, Michael Gersemann, Jan Wehkamp, Irmgard Kübler, Paul Rutgeerts, Severine Vermeire, Walter Reinisch
Publikováno v:
Gastroenterology. 142:S-23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe9ec10e4ebcd41e9b175c0cbda8b801
https://doi.org/10.1016/s0016-5085(12)60091-2
https://doi.org/10.1016/s0016-5085(12)60091-2
Autor:
Severine Vermeire, Guoxing Wang, Derek P. Jewell, Matthias Schwab, Paul Rutgeerts, Michael Gersemann, Elke Schaeffeler, Walter Reinisch, Irmgard Kübler, Maureen J. Koslowski, Eduard F. Stange, Zora Teltschik, Jan Wehkamp, Julia Beisner, Rachel Cooney
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 8, Iss 2, p e1002523 (2012)
PLoS Genetics, Vol 8, Iss 2, p e1002523 (2012)
Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the antimicrobial peptides DEFA5 (HD-5) and DEFA6 (HD-6). Both of these α-defensins are exclusively produced in Paneth cells (PCs) at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d54280310268fad6f8eb9b614695550
https://doi.org/10.1371/journal.pgen.1002523
https://doi.org/10.1371/journal.pgen.1002523
Autor:
Jan Wehkamp, Svetlana Becker, Maureen J. Koslowski, Julia Beisner, Eduard F. Stange, Michael Gersemann
Publikováno v:
Gastroenterology. 138:S-269
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d55e77caa3301c5ccb7dcf4fd1541c6a
https://doi.org/10.1016/s0016-5085(10)61236-x
https://doi.org/10.1016/s0016-5085(10)61236-x