Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Maureen Holly"'
Autor:
Ming-Chu Hsu, Douglas D. Richman, Mary Jane Potash, Lee W. Slice, David J. Volsky, Andrew D. Schutt, Maureen Holly, Michael I. Sherman
Publikováno v:
Science. 254:1799-1802
The human immunodeficiency virus-1 (HIV-1) trans-activator Tat is an attractive target for the development of antiviral drugs because inhibition of Tat would arrest the virus at an early stage. The drug Ro 5-3335 [7-chloro-5-(2-pyrryl)-3H-1,4-benzodi
Autor:
Bogda Wegrzynski, Carlo Nalin, Ming Chu Hsu, Lee W. Slice, Eileen Codner, Douglas Antelman, Maureen Holly, Jin Wang, Voldemar Toome
Publikováno v:
Biochemistry. 31(48)
Recombinant HIV-1 Tat (Tat 1-86) has been purified from the cytoplasmic fraction of Escherichia coli without the use of protein denaturants or chaotropic agents. Chloroquine-mediated uptake of the purified protein into cells resulted in transactivati
Autor:
Andrew D. Schutt, Michael I. Sherman, Maureen Holly, Ming-Chu Hsu, David J. Volsky, Douglas D. Richman, Mary Jane Potash, Lee W. Slice
Publikováno v:
Biochemical Society transactions. 20(2)
Ro 5-3335, 7-chloro-5-(2-pyrryl)-3H-1,4-benzo-diazepin-2-(H)-one, has been shown to inhibit gene expression controlled by the human immunodeficiency virus-1 (HIV-1) LTR promoter. The inhibition was specific for the viral transcriptional transactivato
Publikováno v:
Life Sciences. 33:715-718
Genetically obese mice (C57BL6/J-ob/ob) have enhanced resistance to metastasis of the B16 melanoma in comparison with lean littermate controls. Here we show that this difference is not due to differences in the health status of these mice. We show al