Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maureen H. Beresini"'
Autor:
Elena Ferri, Adrien Le Thomas, Heidi Ackerly Wallweber, Eric S. Day, Benjamin T. Walters, Susan E. Kaufman, Marie-Gabrielle Braun, Kevin R. Clark, Maureen H. Beresini, Kyle Mortara, Yung-Chia A. Chen, Breanna Canter, Wilson Phung, Peter S. Liu, Alfred Lammens, Avi Ashkenazi, Joachim Rudolph, Weiru Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The RNase activity of Inositol-Requiring Enzyme 1 (IRE1) can be allosterically regulated by ATP-competitive inhibitors of the IRE1 kinase domain. Here, the authors identify ATP-competitive IRE1 RNase activators with improved selectivity and cellular
Externí odkaz:
https://doaj.org/article/b949b998bea04b119070c87d6eced201
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e6d4475a0ae89a8c2dfdd5ab0fdb742
https://doi.org/10.1158/0008-5472.22415367.v1
https://doi.org/10.1158/0008-5472.22415367.v1
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
Bromodomain selectivity data for GNE-049 using BROMOscan® panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b2ed65b009a3d6a8d0c6d6fdb82b76
https://doi.org/10.1158/0008-5472.22415364
https://doi.org/10.1158/0008-5472.22415364
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
qPCR analysis of Myc expression after GNE-049 treatment, effects of GNE-049 combination treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348bd12eb407d5287c888e7de21bcfb1
https://doi.org/10.1158/0008-5472.22415379
https://doi.org/10.1158/0008-5472.22415379
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
GNE-049 chemical synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272c8ba9d74f81c9f661d51828b510a5
https://doi.org/10.1158/0008-5472.22415370.v1
https://doi.org/10.1158/0008-5472.22415370.v1
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
Resistance invariably develops to antiandrogen therapies used to treat newly diagnosed prostate cancers, but effective treatments for castration-resistant disease remain elusive. Here, we report that the transcriptional coactivator CBP/p300 is requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2a174442441346b475aa53f3b8dc698
https://doi.org/10.1158/0008-5472.c.6509253.v1
https://doi.org/10.1158/0008-5472.c.6509253.v1
Autor:
Ke Sherry Li, John G. Quinn, Matthew J. Saabye, Jesus F. Salcido Guerrero, Jim Nonomiya, Qihui Lian, Wilson Phung, Yevgeniy Izrayelit, Benjamin T. Walters, Amy Gustafson, Nicholas F. Endres, Maureen H. Beresini, Melinda M. Mulvihill
Publikováno v:
Analytical Chemistry. 94:1230-1239
Autor:
Shumei Wang, Vickie Tsui, Terry D. Crawford, James E. Audia, Daniel J. Burdick, Maureen H. Beresini, Alexandre Côté, Richard Cummings, Martin Duplessis, E. Megan Flynn, Michael C. Hewitt, Hon-Ren Huang, Hariharan Jayaram, Ying Jiang, Shivangi Joshi, Jeremy Murray, Christopher G. Nasveschuk, Eneida Pardo, Florence Poy, F. Anthony Romero, Yong Tang, Alexander M. Taylor, Jian Wang, Zhaowu Xu, Laura E. Zawadzke, Xiaoyu Zhu, Brian K. Albrecht, Steven R. Magnuson, Steve Bellon, Andrea G. Cochran
Publikováno v:
Journal of medicinal chemistry. 61(20)
The biological functions of the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1(1,2)) remain unknown, although TAF1 has been identified as a potential target for oncology research. Here, we describe the discovery of a
Autor:
and Thomas Keough, Sari J. Paikoff, Lea T. Berleau, Maureen H. Beresini, Peter G. Schultz, Andrea R. Hebert, Corey W. Liu, Charles Y. Cho, R. Scott Youngquist, David E. Wemmer
Publikováno v:
Journal of the American Chemical Society. 120:7706-7718
Synthetic methodology has been developed for the generation of large, diverse libraries of “unnatural” carbamate oligomers using the “one bead, one peptide” method. Using a pool of 27 structurally and functionally diverse monomers, one acycli
Autor:
Georgette M, Castanedo, Fredrick C, Sailes, Nathan J P, Dubree, John B, Nicholas, Lisa, Caris, Kevin, Clark, Susan M, Keating, Maureen H, Beresini, Henry, Chiu, Sherman, Fong, James C, Marsters, David Y, Jackson, Daniel P, Sutherlin
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(20)
Two structural classes of dual alpha4beta1/alpha4beta7 integrin antagonists were investigated via solid-phase parallel synthesis. Using an acylated amino acid backbone, lead compounds containing biphenylalanine or tyrosine carbamate scaffolds were op