Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Maureen Gannon"'
Autor:
Anthony S. Wokasch, Maureen Gannon
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114897- (2024)
In two recent issues of Cell Reports, Kaplan et al.1 and Merz et al.2 identify a distal enhancer region within the OC1 gene and demonstrate its relevance to OC1 expression, pancreatic endocrine differentiation, and diabetes susceptibility.
Externí odkaz:
https://doaj.org/article/5aba0f386b14441e9582ddac08cbece4
Autor:
Darian T. Carroll, Allie Miller, Jennifer Fuhr, Joseph M. Elsakr, Valerie Ricciardi, Alexa N. Del Bene, Stedman Stephens, Evan Krystofiak, Sarah R. Lindsley, Melissa Kirigiti, Diana L. Takahashi, Tyler A. Dean, Stephanie R. Wesolowski, Carrie E. McCurdy, Jacob E. Friedman, Kjersti M. Aagaard, Paul Kievit, Maureen Gannon
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionUsing a non-human primate (NHP) model of maternal Western-style diet (mWSD) feeding during pregnancy and lactation, we previously reported altered offspring beta:alpha cell ratio in vivo and insulin hyper-secretion ex vivo. Mitochondria a
Externí odkaz:
https://doaj.org/article/2aefe612d931437fb2599f63ef8e7bf0
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Taylor K. Soderborg, Rachel C. Janssen, Diana L. Takahashi, Tyler A. Dean, Oleg Varlamov, Jon D. Hennebold, Maureen Gannon, Kjersti M. Aagaard, Carrie E. McCurdy, Paul Kievit, Bryan C. Bergman, Kenneth L. Jones, Eric M. Pietras, Stephanie R. Wesolowski, Jacob E. Friedman
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112393- (2023)
Summary: Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal offspring. This constitutes a major public health concern due to increasing prevalence of these diseases, yet mechanisms remain unclear. Here, using nonhum
Externí odkaz:
https://doaj.org/article/61f8abfb16c94221819b0fcca9d1aea3
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Rachel C. Janssen, Mark A. Lovell, Deborah A. Schady, Claire Levek, Kenneth L. Jones, Angelo D’Alessandro, Paul Kievit, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Jacob E. Friedman, Stephanie R. Wesolowski
Publikováno v:
Hepatology Communications, Vol 7, Iss 2, Pp e0014-e0014 (2023)
Pediatric NAFLD has distinct and variable pathology, yet causation remains unclear. We have shown that maternal Western-style diet (mWSD) compared with maternal chow diet (CD) consumption in nonhuman primates produces hepatic injury and steatosis in
Externí odkaz:
https://doaj.org/article/6bcad75da676422bbcbdb90a6e13d609
Autor:
Joseph M. Elsakr, Sifang Kathy Zhao, Valerie Ricciardi, Tyler A. Dean, Diana L. Takahashi, Elinor Sullivan, Stephanie R. Wesolowski, Carrie E. McCurdy, Paul Kievit, Jacob E. Friedman, Kjersti M. Aagaard, Digna R. Velez Edwards, Maureen Gannon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The prevalence of maternal obesity is increasing in the United States. Offspring born to women with obesity or poor glycemic control have greater odds of becoming obese and developing metabolic disease later in life. Our group has utilized a
Externí odkaz:
https://doaj.org/article/aa19a82e9f5149fe9535985f2027cb5b
Autor:
Eugenia Martin Vázquez, Nadia Cobo-Vuilleumier, Raquel Araujo Legido, Sandra Marín-Cañas, Emanuele Nola, Akaitz Dorronsoro, Lucia López Bermudo, Alejandra Crespo, Silvana Y. Romero-Zerbo, Maria García-Fernández, Alejandro Martin Montalvo, Anabel Rojas, Valentine Comaills, Francisco J. Bérmudez-Silva, Maureen Gannon, Franz Martin, Decio Eizirik, Petra I. Lorenzo, Benoit R. Gauthier
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104345- (2022)
Summary: LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse models of Type 1 Diabetes Mellitus. Islet transcriptome profiling re
Externí odkaz:
https://doaj.org/article/8058666987f74aa8a44031e045ebfaf8
Autor:
Karin J. Bosma, Monica Ghosh, Spencer R. Andrei, Lin Zhong, Jennifer C. Dunn, Valerie F. Ricciardi, Juliann B. Burkett, Antonis K. Hatzopoulos, Derek S. Damron, Maureen Gannon
Publikováno v:
Physiological Reports, Vol 10, Iss 7, Pp n/a-n/a (2022)
Abstract Type 2 diabetes (T2D) affects >30 million Americans and nearly 70% of individuals with T2D will die from cardiovascular disease (CVD). Circulating levels of the inflammatory signaling lipid, prostaglandin E2 (PGE2), are elevated in the setti
Externí odkaz:
https://doaj.org/article/6833e123a5be47539795aa50463c9b99
Autor:
Peter A. Kropp, Gabrielle V. Rushing, Asa A. Brockman, Erin N. Z. Yu, Rebecca A. Ihrie, Maureen Gannon
Publikováno v:
Laboratory Animal Research, Vol 36, Iss 1, Pp 1-5 (2020)
Abstract Background Anti-parasitics are frequently used in research animal facilities to treat a multitude of common infections, with pinworms and fur mites being amongst the most common. Ivermectin and selamectin are common oral and topical treatmen
Externí odkaz:
https://doaj.org/article/e3afecc0737e4db3bff177d0ddd797e4
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Sean A. Newsom, Ilhem Messaoudi, Rachel C. Janssen, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Paul Kievit, Jacob E. Friedman, Stephanie R. Wesolowski
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Maternal obesity affects nearly one-third of pregnancies and is a major risk factor for nonalcoholic fatty liver disease (NAFLD) in adolescent offspring, yet the mechanisms behind NAFLD remain poorly understood. Here, we demonstrate that nonhuman pri
Externí odkaz:
https://doaj.org/article/74abddaa583647bc9452d4301229be48
Autor:
Karin J. Bosma, Spencer R. Andrei, Liora S. Katz, Ashley A. Smith, Jennifer C. Dunn, Valerie F. Ricciardi, Marisol A. Ramirez, Sharon Baumel-Alterzon, William A. Pace, Darian T. Carroll, Emily M. Overway, Elysa M. Wolf, Michelle E. Kimple, Quanhu Sheng, Donald K. Scott, Richard M. Breyer, Maureen Gannon
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101347- (2021)
Objective: Type 2 diabetes is characterized by hyperglycemia and inflammation. Prostaglandin E2, which signals through four G protein-coupled receptors (EP1-4), is a mediator of inflammation and is upregulated in diabetes. We have shown previously th
Externí odkaz:
https://doaj.org/article/938250ff8f6d4937886d25473129e45f