Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Maureen E, Balestra"'
Autor:
Yadong Huang, Alice Taubes, Marina Sirota, Tomiko Oskotsky, Misha Zilberter, Seo Yeon Yoon, Maureen E. Balestra, Jessica K De Freitas, Krishna Choudhary, Mesude Bicak, Benjamin S. Glicksberg, Brian P. Grone, Yanxia Hao, William Chang, Bin Chen, Ishan Paranjpe, Alice An, Celine Wang, Phil Nova, Emily Jones, Nuo Chen, Kelly A. Zalocusky, Nicole Koutsodendris, Fayzan Chaudhry, Silvia Pineda, Idit Kosti
Publikováno v:
Nature Aging. 1:932-947
The evident genetic, pathological and clinical heterogeneity of Alzheimer’s disease (AD) poses challenges for traditional drug development. We conducted a computational drug-repurposing screen for drugs to treat apolipoprotein E4 (APOE4)-related AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344ed394816c2d740eafbb790b588598
https://doi.org/10.1038/s43587-021-00122-7
https://doi.org/10.1038/s43587-021-00122-7
Autor:
Alice, Taubes, Phil, Nova, Kelly A, Zalocusky, Idit, Kosti, Mesude, Bicak, Misha Y, Zilberter, Yanxia, Hao, Seo Yeon, Yoon, Tomiko, Oskotsky, Silvia, Pineda, Bin, Chen, Emily A Aery, Jones, Krishna, Choudhary, Brian, Grone, Maureen E, Balestra, Fayzan, Chaudhry, Ishan, Paranjpe, Jessica, De Freitas, Nicole, Koutsodendris, Nuo, Chen, Celine, Wang, William, Chang, Alice, An, Benjamin S, Glicksberg, Marina, Sirota, Yadong, Huang
Publikováno v:
Nat Aging
The evident genetic, pathological, and clinical heterogeneity of Alzheimer’s disease (AD) poses challenges for traditional drug development. We conducted a computational drug repurposing screen for drugs to treat apolipoprotein (apo) E4-related AD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::280579c1090f3d62b13565055133fa5b
https://pubmed.ncbi.nlm.nih.gov/36172600
https://pubmed.ncbi.nlm.nih.gov/36172600
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 11, Pp 1783-1789 (2000)
Apolipoprotein E7 (apoE7) (apoE3 E244K/E245K) is a naturally occurring mutant in humans that is associated with increased plasma lipid levels and accelerated atherosclerosis. It is reported to display defective binding to low density lipoprotein (LDL
Externí odkaz:
https://doaj.org/article/a52f65829be64b8da72fb5a3af3db4de
Autor:
Marina Sirota, Alice An, Yadong Huang, Alice Taubes, Celine Wang, Phil Nova, Bin Chen, Tomiko Oskotsky, Maureen E. Balestra, Mesude Bicak, Yanxia Hao, Krishna Choudhary, Kelly A. Zalocusky, Benjamin S. Glicksberg, Ishan Paranjpe, Idit Kosti, Seo Yeon Yoon, Jessica K De Freitas, Nuo Chen, Fayzan Chaudhry, William Chang, Nicole Koutsodendris, Misha Zilberter, Emily Jones, Silvia Pineda, Brian P. Grone
Publikováno v:
Nature Aging. 1:1202-1202
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ea2c837eb6e79ee5f2fa2ecb961d38b
https://doi.org/10.1038/s43587-021-00144-1
https://doi.org/10.1038/s43587-021-00144-1
Autor:
Ethan G. Geier, Mathieu Bourdenx, Jennifer S. Yokoyama, Anna Karydas, Suzee E. Lee, Salvatore Spina, J. Nicholas Cochran, Giovanni Coppola, Lea T. Grinberg, Deepika Dokuru, Ana Maria Cuervo, Ji Hye Hwang, Richard M. Myers, Nadia J. Storm, Victoria Van Berlo, Alissa L. Nana, Yadong Huang, Maureen E. Balestra, Bruce L. Miller, Antonio Diaz, Luke W. Bonham, Daniel W. Sirkis, Eliana Marisa Ramos, Silvia P. Russo, William W. Seeley
Publikováno v:
Acta neuropathologica, vol 137, iss 1
Pathogenic variation in MAPT, GRN, and C9ORF72 accounts for at most only half of frontotemporal lobar degeneration (FTLD) cases with a family history of neurological disease. This suggests additional variants and genes that remain to be identified as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803641db211904a77e071f3e2116e915
https://escholarship.org/uc/item/9qm0q5dj
https://escholarship.org/uc/item/9qm0q5dj
Autor:
Heidi Yuan, Qin Xu, Dah-Eun Jeong, Ramsey Najm, Maureen E. Balestra, Zachary A. Miller, Yadong Huang, Mary J. Malloy, Bruce L. Miller, Gang Li, Chengzhong Wang, David Walker, Seo Yeon Yoon
Publikováno v:
Wang, C; Najm, R; Xu, Q; Jeong, D-E; Walker, D; Balestra, ME; et al.(2018). Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. NATURE MEDICINE, 24(5), 647-+. doi: 10.1038/s41591-018-0004-z. UCSF: Retrieved from: http://www.escholarship.org/uc/item/796161bm
Nature medicine, vol 24, iss 5
Nature medicine
Nature medicine, vol 24, iss 5
Nature medicine
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using human neurons derived from induced pluripotent stem cells t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce54f33017d611954ee58cce37f37b4f
http://www.escholarship.org/uc/item/796161bm
http://www.escholarship.org/uc/item/796161bm
Autor:
Maureen E. Balestra, Mihir A. Kshirsagar, William W. Seeley, David Walker, Johanna Knoferle, Bruce L. Miller, Karen Ring, Laura Leung, Helen Fong, Anna Karydas, Chengzhong Wang, Yadong Huang, Kenneth S. Kosik, Leslie M. Tong, Adam L. Boxer
Publikováno v:
Stem Cell Reports
Fong, H; Wang, C; Knoferle, J; Walker, D; Balestra, ME; Tong, LM; et al.(2013). Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. Stem Cell Reports, 1(3), 226-234. doi: 10.1016/j.stemcr.2013.08.001. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2895x5c3
Stem cell reports, vol 1, iss 3
Fong, H; Wang, C; Knoferle, J; Walker, D; Balestra, ME; Tong, LM; et al.(2013). Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. Stem Cell Reports, 1(3), 226-234. doi: 10.1016/j.stemcr.2013.08.001. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2895x5c3
Stem cell reports, vol 1, iss 3
Summary Tauopathies represent a group of neurodegenerative disorders characterized by the accumulation of pathological TAU protein in brains. We report a human neuronal model of tauopathy derived from induced pluripotent stem cells (iPSCs) carrying a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28862c77f0695870f181497669f14005
http://europepmc.org/articles/PMC3849235
http://europepmc.org/articles/PMC3849235
Autor:
Zhong Sheng Ji, Maureen E. Balestra, Michael A. Pleiss, Dah Eun Jeong, Anke Meyer-Franke, Qin Xu, David W. Walker, Zhaoping Liu, Karl H. Weisgraber, Yadong Huang, John C. Voss, Stephen B. Freedman, Jens Brodbeck, Rene D. Miranda, Hung Kai Chen, James G. McGuire, Madhu S. Budamagunta, Robert W. Mahley
Publikováno v:
Journal of Biological Chemistry. 287:5253-5266
Apolipoprotein E4 (apoE4), the major genetic risk factor for late onset Alzheimer disease, assumes a pathological conformation, intramolecular domain interaction. ApoE4 domain interaction mediates the detrimental effects of apoE4, including decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a7cef155e044df87d4f19e336db86d
https://doi.org/10.1074/jbc.m111.276162
https://doi.org/10.1074/jbc.m111.276162
Publikováno v:
The Journal of Neuroscience. 28:1452-1459
Neuronal expression of apolipoprotein (apo) E4 may contribute to the pathogenesis of Alzheimer's disease (AD). In studying how apoE expression is regulated in neurons, we identified a splicing variant of apoE mRNA with intron-3 retention (apoE-I3). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f123d4a30b1b7af4d340b296d0269f5
https://doi.org/10.1523/jneurosci.3253-07.2008
https://doi.org/10.1523/jneurosci.3253-07.2008
Autor:
Robert W. Mahley, Jens Brodbeck, Ann M. Saunders, Yadong Huang, Maureen E. Balestra, Allen D. Roses
Publikováno v:
Proceedings of the National Academy of Sciences. 105:1343-1346
Convergent evidence has revealed an association between insulin resistance and Alzheimer's disease (AD), and the peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, rosiglitazone, an insulin sensitizer and mitochondrial activator, improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f08cfdf72f7aef5054e3208c6bb08dd
https://doi.org/10.1073/pnas.0709906104
https://doi.org/10.1073/pnas.0709906104