Výsledky vyhledávání - "Maureen C. Gammon"

Mutation of the alpha 2 domain disulfide bridge of the class I molecule HLA-A*0201. Effect on maturation and peptide presentation

Autor: Michael Edidin, Andrew J. McMichael, Taiyin Wei, Gil E. Katzenstein, Masanori Matsui, Jeffrey A. Frelinger, H J Zweerink, Maureen C. Gammon, Sarah Rowland-Jones, Robert J. Warburton

A combination of saturation and site-directed mutagenesis was utilized to disrupt the alpha 2 domain disulfide bridge of HLA-A*0201. Mutation of cysteine 101 to a serine (C101S) or of cysteine 164 to alanine (C164A) decreased the rate of maturation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d38a43857ea7d43a2f9a9baadb4008b
https://ora.ox.ac.uk/objects/uuid:54de532d-5363-4f5a-b041-4844526196f0

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Functional significance of varied quantitative and qualitative expression of HLA-A2.1 antigens in determining the susceptibility of cells to cytotoxic T lymphocytes

Autor: H J Zweerink, K.J. Kao, Maureen C. Gammon, Dong-Chen Shieh

Publikováno v: Human Immunology. 46:18-26

To determine whether varied quantitative HLA expression affects the susceptibility of target cells to CTLs, a panel of 15 EBV-transformed lymphoblastoid cell lines expressing a fivefold difference of surface HLA-A2.1 antigens were employed. The susce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f44fb3c8d32a20bde5d103059cde7a8
https://doi.org/10.1016/0198-8859(96)00008-0

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Recognition by HLA-A2-restricted cytotoxic T lymphocytes of endogenously generated and exogenously provided synthetic peptide analogues of the influenza a virus matrix protein

Autor: H J Zweerink, William E. Biddison, Maureen C. Gammon, Samir Y. Sauma, Julio C. Hawkins, Bruce L. Bush, Snehal Tamhankar, Maria A. Bednarek, Gene Porter, Alan R. Williamson, Barry R. Cunningham, Jeffrey D. Hermes

Publikováno v: Human Immunology. 37:252-258

Experiments were carried out to determine whether complexes between MHC class I molecules and synthetic peptides are representative of those formed under more physiologically relevant conditions, with peptides derived intracellularly from processed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9df80d8f31760299a2dc2c3d0c1e0c
https://doi.org/10.1016/0198-8859(93)90508-x

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Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity

Autor: H J Zweerink, D. Boulton, J T Blake, Maureen C. Gammon, Martin Poe, Joseph K. Wu, Nolan H. Sigal

Publikováno v: Journal of Biological Chemistry. 266:98-103

Granzyme B has been purified to homogeneity from the granules of a human cytolytic lymphocyte line, Q31, in an enzymatically active form by a three-step procedure. Q31 granzyme B hydrolyzed Na-t-butyloxycarbonyl-L-alanyl-L-alanyl-L-aspartyl (Boc-Ala-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9d7e03fdea1182f39212775bd00eb03
https://doi.org/10.1016/s0021-9258(18)52407-8

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Mediation by HLA-DM of dissociation of peptides from HLA-DR

Autor: Dennis M. Zaller, Maureen C. Gammon, Victor S. Sloan, Miguel Amaya, Elizabeth D. Mellins, Gene Porter, Patricia M. Cameron

Publikováno v: Nature. 375(6534)

Human leukocyte antigen (HLA)-DM is an unconventional major histocompatibility complex (MHC) class II heterodimer that is important for B-cell-mediated antigen processing and presentation to MHC class II-restricted T cells. HLA-DM is encoded by two g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862fdcce3b2be456797bbe635ad4cb62
https://pubmed.ncbi.nlm.nih.gov/7596415

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Soluble HLA-A2.1 restricted peptides that are recognized by influenza virus specific cytotoxic T lymphocytes

Autor: Alan R. Williamson, Gene Porter, H J Zweerink, Maria A. Bednarek, Sara A. Engl, Maureen C. Gammon, Jonathan A. Lindquist

Publikováno v: Journal of immunological methods. 139(1)

The influenza A virus matrix derived peptide with amino acids 57–68 (Lys-Gly-Ileu-Leu-Gly-Phe-Val-Phe-Thr-Leu-Thr-Val) is recognized by influenza virus HLA-A2 restricted CTL. Because of the large number of hydrophobic residues this peptide is very

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2ce8ecccfd4973581f286976ae4e4c
https://pubmed.ncbi.nlm.nih.gov/1904085

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A human monoclonal antibody that protects mice against Pseudomonas-induced pneumonia

Autor: H J Zweerink, Maureen C. Gammon, Louis J. DetoUa, Cameron F. Hutchison, Nolan H. Sigal, Jane M. Puckett

Publikováno v: The Journal of infectious diseases. 162(1)

X-linked immunodeficient (xid) (CBA/N female x DBA/2 male) F1 male mice, when treated with cyclophosphamide, were much more susceptible to challenge with aerosolized Pseudomonas aeruginosa serotype 11 than were control F1 female littermates. Mortalit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe724aa06ba6ef8d1fd1028eb6fd3a61
https://pubmed.ncbi.nlm.nih.gov/2113078

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Heterohybridomas that secrete high levels of pseudomonas-specific therapeutic human monoclonal antibodies: their generation and large scale growth in an automated hollow fiber cell culture system

Autor: H J Zweerink, Maureen C. Gammon, Nolan H. Sigal, Martin H. Banas, Louis E. Boccumini

Publikováno v: Cytotechnology. 3(1)

Fusion of lymphoblastoid cell lines that produce human monoclonal antibodies against Pseudomonas aeruginosa with the human/mouse heteromyeloma SHM-D33 generated heterohybrids that were stable and secreted antibody in the range of 20 to 300 micrograms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c09da9a33afd4ae81bcad6833b2b77
https://pubmed.ncbi.nlm.nih.gov/1367460

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Eimeria tenella: quantitative in vitro and in vivo studies on the effects of mouse polyclonal and monoclonal antibodies on sporozoites

Autor: Mark S. Crane, Ann C. Tate, Deborah J. Norman, Mark J. Gnozzio, Maureen C. Gammon, P. Keith Murray

Publikováno v: Parasite Immunology. 8:467-480

Summary Murine, polyclonal and monoclonal antibodies, raised against sporozoites of Eimeria tenella, were tested for their ability to neutralize sporozoite infectivity in vitro and in vivo. Neutralization was effected via three mechanisms. Firstly, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43df90049ef45a536e1b73a04de885ca
https://doi.org/10.1111/j.1365-3024.1986.tb00862.x

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X-linked immunodeficient mice as a model for testing the protective efficacy of monoclonal antibodies against Pseudomonas aeruginosa

Autor: J J Jackson, Gerald B. Pier, Cameron F. Hutchison, J M Puckett, Maureen C. Gammon, H J Zweerink, T J Sewell, Nolan H. Sigal

Publikováno v: Europe PubMed Central
CIÊNCIAVITAE

(DBA/N[female] X CBA/2[male])F1 males have been reported to be deficient in producing antibodies against a number of antigens, including carbohydrates (I. Scher, Adv. Immunol. 35:1-71, 1982). We show that F1 male mice, in contrast to females, made le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c2ec08395e60b0d2cd4c4e5452aa68
https://pubmed.ncbi.nlm.nih.gov/3128480

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