Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Maureen Beresini"'
Autor:
John C. Tran, Thomas Hunsaker, Christina Bell, Taylur P. Ma, Emily Chan, Pablo Saenz-Lopez Larrocha, Kelsey Homyk, Liling Liu, Hank La, Jialin Mao, Cecile C. de la Cruz, Kebing Yu, Maureen Beresini, William F. Forrest, Yang Xiao, Anne Jang, Natalia Samus, Nicholas Dupuis Stesco, Marija Mentinova, Stephane Parent, Gwenael Pottiez, Michael Schirm, Hans E. Purkey, Yichin Liu, Mark Merchant
Publikováno v:
Analytical Chemistry. 95:4834-4839
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ea38580cf5f1df5004a2b5d1c9e5ae9
https://doi.org/10.1021/acs.analchem.2c04417
https://doi.org/10.1021/acs.analchem.2c04417
Autor:
Hem Gurung, Amy Heidersbach, Martine Darwish, Pamela Chan, Jenny Li, Maureen Beresini, Oliver Zill, Andrew Wallace, Ann-Jay Tong, Dan Hascall, Eric Torres, Andy Chang, Kenny 'Hei-Wai' Lou, Yassan Abdolazimi, Amanda Moore, Uzodinma Uche, Melanie Laur, Richard Notturno, Peter J.R. Ebert, Craig Blanchette, Benjamin Haley, Christopher M. Rose
SummaryStrategies for maximizing the potency and specificity of cancer immunotherapies have sparked efforts to identify recurrent epitopes presented in the context of defined tumor-associated neoantigens. Discovering these “neoepitopes” can be di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6317922554eb98fcf714d679f289ec76
https://doi.org/10.1101/2022.10.27.513529
https://doi.org/10.1101/2022.10.27.513529
Autor:
Breanna Canter, Benjamin T. Walters, Alfred Lammens, Peter Liu, Avi Ashkenazi, Wilson Phung, Weiru Wang, Kevin R Clark, Adrien Le Thomas, Joachim Rudolph, Heidi J.A. Wallweber, Elena Ferri, Eric S. Day, Kyle Mortara, Maureen Beresini, Marie-Gabrielle Braun, Yung-Chia A. Chen, Susan Kaufman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Inositol-Requiring Enzyme 1 (IRE1) is an essential component of the Unfolded Protein Response. IRE1 spans the endoplasmic reticulum membrane, comprising a sensory lumenal domain, and tandem kinase and endoribonuclease (RNase) cytoplasmic domains. Exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bd7a014003dc6f7f6d9ef04c6b5f4a
https://doaj.org/article/b949b998bea04b119070c87d6eced201
https://doaj.org/article/b949b998bea04b119070c87d6eced201
Autor:
Sanjay Srivastava, Susan Kaufman, Joachim Rudolph, Ghiro Elise, Heidi J.A. Wallweber, Jean-Philippe Leclerc, Beveridge Ramsay, Liang Zhao, Marie-Gabrielle Braun, Lemire Alexandre, Mélissa Leblanc, Alexandre Larivée, Cuong Ly, Weiru Wang, Avi Ashkenazi, Maureen Beresini, Jacob Schwarz, Paul Gibbons, Kevin R Clark
Publikováno v:
ACS Med Chem Lett
[Image: see text] Amino-quinazoline BRaf kinase inhibitor 2 was identified from a library screen as a modest inhibitor of the unfolded protein response (UPR) regulating potential anticancer target IRE1α. A combination of crystallographic and conform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082aa3dbc959d40a4b3123339657e04c
https://europepmc.org/articles/PMC7734639/
https://europepmc.org/articles/PMC7734639/
Autor:
Daniel J. Burdick, Monica Kong-Beltran, Huy Nguyen, Mark Ultsch, Nicholas J. Skelton, Yingnan Zhang, Wei Li, Maureen Beresini, Charles Eigenbrot, John G. Quinn, Daniel Kirchhofer
Publikováno v:
ACS chemical biology. 15(2)
Proprotein convertase subtilisin/kexin 9 (PCSK9) has become an important therapeutic target for lipid lowering, since it regulates low-density lipoprotein cholesterol (LDL-c) levels by binding to liver LDL receptors (LDLR) and effecting their intrace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2395f75f47918198653cff1accf7c68
https://pubmed.ncbi.nlm.nih.gov/31962046
https://pubmed.ncbi.nlm.nih.gov/31962046
Autor:
Mike Reichelt, Inna Zilberleyb, Hans E. Purkey, Hoangdung Ho, Benjamin D. Sellers, Maureen Beresini, Jian Payandeh, Vishal Verma, Natalie K. Garcia, Yvonne Franke, Yan Lu, Till Maurer, James R. Kiefer, Angela Oh, John G. Quinn, Aaron T. Wecksler, Yiming Xu, Mary Kate Alexander, Man-Wah Tan, Anh Miu, Stephanie Shriver, Christopher M. Koth, Jun Liang, Christine Tam, Mireille Nishiyama, Sharada Labadie, Michael F. T. Koehler, Kevin R Clark, Huiyong Hu, Jian Wang, Lan Wang, Cary D. Austin
Publikováno v:
Nature. 557:196-201
The movement of core-lipopolysaccharide across the inner membrane of Gram-negative bacteria is catalysed by an essential ATP-binding cassette transporter, MsbA. Recent structures of MsbA and related transporters have provided insights into the molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cdded180233b15f2f4abb1c64264d81
https://doi.org/10.1038/s41586-018-0083-5
https://doi.org/10.1038/s41586-018-0083-5
Autor:
Steven W. Jones, Chang Liu, Daniel F. Ortwine, David H. Hackos, Maureen Beresini, Henry Verschoof, Tianbo Li, Steven J. McKerrall, Jun Chen, Daniel P. Sutherlin, Charles J. Cohen, Kuldip Khakh, Gang Lu, Tania Chernov-Rogan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Subtype-selective modulation of ion channels is often important, but extremely difficult to achieve for drug development. Using Nav1.7 as an example, we show that this challenge could be attributed to poor design in ion channel assays, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a61efe267f7dcc33ea85b5750295e6b
http://europepmc.org/articles/PMC5789920
http://europepmc.org/articles/PMC5789920
Autor:
Maureen Beresini, Vickie Tsui, John S. Wai, F. Anthony Romero, Gladys de Leon Boenig, Patrick Cyr, Xiaoyu Zhu, Kevin X. Chen, Jiangpeng Liao, Edna F. Choo, Susan Kaufman, Fei Wang, Kwong Wah Lai, Caicai Zhu, Zhongguo Chen, Terry Crawford, Weichao Shen, Wenfeng Liu, Jeremy Murray, Yingjie Li, Sarah M. Bronner, Steven Magnuson, Justin Ly
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:15-23
A novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP, compound 35 (GNE-207), has been identified through SAR investigations focused on optimizing al bicyclic heteroarene to replace the aniline present in the published GNE-272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a093625fe16457098a0a0b8d624a6c4e
https://doi.org/10.1016/j.bmcl.2017.11.025
https://doi.org/10.1016/j.bmcl.2017.11.025
Autor:
William F. Forrest, Sumit Prakash, Vickie Tsui, Adam R. Renslo, Richard Pastor, Christiaan Klijn, Frank Peale, Mark McCleland, Lorna Kategaya, Carsten Schwerdtfeger, Zachary Stiffler, Matthias Trost, Frederick Cohen, Priyadarshini Jaishankar, Kevin R Clark, Paola Di Lello, Bradley B. Brasher, Florian Gnad, Michael C. M. Kwok, Johanna Heideker, Jeremy Murray, Jason Drummond, Xiaojing Wang, Maria Stella Ritorto, Till Maurer, Maureen Beresini, Matthew T. Chang, James A. Ernst, Taylur P. Ma, Robert A. Blake, Elizabeth Blackwood, Dario R. Alessi, Michelle R. Arkin, Lionel Rouge, Kebing Yu, Brian R. Hearn, Travis W. Bainbridge, Eva Lin, Tracy Kleinheinz, Yinyan Tang, Chudi Ndubaku, Scott E. Martin, John-Paul Upton, Ingrid E. Wertz
Publikováno v:
Nature. 550:534-538
The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7. Deubiquitinating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cc98dd9db2eb6f51008b4a3df458a39
https://doi.org/10.1038/nature24006
https://doi.org/10.1038/nature24006
Autor:
Mark Merchant, Ryan Raisner, Maureen Beresini, Edna F. Choo, F. Anthony Romero, Ehud Segal, Susan Kaufman, Karen E. Gascoigne, Samir Kharbanda, Lingyan Jin, Jesse Garcia, Peter M. Haverty, Cecile de la Cruz, Zora Modrusan, Emily Chan, Justin Ly, Steven Magnuson
Publikováno v:
Cancer Research. 77:5564-5575
Resistance invariably develops to antiandrogen therapies used to treat newly diagnosed prostate cancers, but effective treatments for castration-resistant disease remain elusive. Here, we report that the transcriptional coactivator CBP/p300 is requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c2a59ba12e30f81fbd77c07f425b19
https://doi.org/10.1158/0008-5472.can-17-0314
https://doi.org/10.1158/0008-5472.can-17-0314