Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maureen A. Jakubowski"'
Publikováno v:
Cancers, Vol 14, Iss 19, p 4814 (2022)
Background and aims: The MET exon 14 skipping (METex14) is an oncogenic driver mutation that provides a therapeutic opportunity in non-small cell lung cancer (NSCLCs) patients. This event often results from sequence changes at the MET canonical splic
Externí odkaz:
https://doaj.org/article/a0f8d7de6fc542458a6940e13df2b977
Publikováno v:
Respiratory Medicine Case Reports, Vol 28, Iss , Pp - (2019)
Background: Allele specific real-time PCR and next-generation sequencing (NGS) are widely used to detect somatic mutation in non-small cell lung cancer (NSCLC). Both methods commonly use formalin-fixed paraffin-embedded (FFPE) tissues as diagnostic m
Externí odkaz:
https://doaj.org/article/7fb46ac363154893ba21cfadce241220
Autor:
Elizabeth M Azzato, Daniel H. Farkas, Anders Meyer, Jay E. Brock, Brian P. Rubin, Maureen A. Jakubowski, Yu-Wei Cheng, Sean O Keenan, Michael D. Weindel
Publikováno v:
The Journal of Applied Laboratory Medicine. 6:917-930
Background Methods for identifying gene fusion events, such as fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), and transcriptome analysis, are either single gene approaches or require bioinformatics expertise not generally avai
Autor:
Yu-Wei Cheng, Jordan P. Reynolds, Francisco A. Almeida, Jennifer Brainard, Zhen Wang, Yaolin Zhou, Roger D. Klein, Maureen A. Jakubowski, Carol Farver
Publikováno v:
Cancer Cytopathology. 125:178-187
BACKGROUND The detection of mutated epidermal growth factor receptor (EGFR) in non–small cell lung cancer (NSCLC) with residual cell pellets derived from liquid-based cytology (LBC) samples (eg, endoscopic ultrasound–guided fine-needle aspiration
Publikováno v:
Respiratory Medicine Case Reports
Respiratory Medicine Case Reports, Vol 28, Iss, Pp-(2019)
Respiratory Medicine Case Reports, Vol 28, Iss, Pp-(2019)
Background: Allele specific real-time PCR and next-generation sequencing (NGS) are widely used to detect somatic mutation in non-small cell lung cancer (NSCLC). Both methods commonly use formalin-fixed paraffin-embedded (FFPE) tissues as diagnostic m
Autor:
Jordan P, Reynolds, Yaolin, Zhou, Maureen A, Jakubowski, Zhen, Wang, Jennifer A, Brainard, Roger D, Klein, Carol F, Farver, Francisco A, Almeida, Yu-Wei, Cheng
Publikováno v:
Cancer cytopathology. 125(3)
The detection of mutated epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) with residual cell pellets derived from liquid-based cytology (LBC) samples (eg, endoscopic ultrasound-guided fine-needle aspiration) has been vali
Publikováno v:
American Journal of Surgical Pathology. 35:1327-1330
To our knowledge, the genotoxic effects of neoadjuvant chemoradiation therapy on molecular diagnostic testing results are unknown. However, if neoadjuvant treatments were to alter molecular test results, clinical decision-making could be misled. This
Publikováno v:
American Journal of Clinical Pathology. 135:245-252
KRAS mutation occurs in 30% to 50% of colorectal cancers (CRCs) and has been suggested to be associated with proliferation and decreased apoptosis. In this study, we analyzed KRAS in 198 CRCs and compared the clinicopathologic variables between KRAS-
BRAF Mutational Analysis in Papillary Carcinomas With Mixed Follicular and Papillary Growth Patterns
Publikováno v:
American Journal of Surgical Pathology. 33:1590-1593
Background Current literature suggests that up to 60% of papillary carcinomas have mutations in the BRAF gene. However, follicular variant of papillary carcinoma has a much lower frequency of mutation. Tumors with mixed patterns of growth, including
Publikováno v:
Blood. 115:3175-3176
To the editor: The JAK2 617V>F point mutation is an important diagnostic tool for Philadelphia chromosome–negative myeloproliferative disorders. JAK2 mutation analysis has been endorsed by the World Health Organization for diagnosing polycythemia v