Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Maureen A Su"'
Autor:
Mariella Valenzise, Simone Foti Randazzese, Fabio Toscano, Fortunato Lombardo, Giuseppina Salzano, Cristina Pajno, Malgorzata Wasniewska, Antonio Cascio, Maureen A Su
Publikováno v:
Pathogens, Vol 12, Iss 3, p 403 (2023)
Autoimmune-Poly-Endocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED), caused by mutations in the Autoimmune Regulator (AIRE) gene, is an autosomal recessive multi-organ autoimmunity syndrome usually defined by high serum titers of type I Interfer
Externí odkaz:
https://doaj.org/article/cc8f6330bd1d4b929a5379b3f5c4012b
Autor:
Melissa G. Lechner, Zikang Zhou, Aline T. Hoang, Nicole Huang, Jessica Ortega, Lauren N. Scott, Ho-Chung Chen, Anushi Y. Patel, Rana Yakhshi-Tafti, Kristy Kim, Willy Hugo, Pouyan Famini, Alexandra Drakaki, Antoni Ribas, Trevor E. Angell, Maureen A. Su
Publikováno v:
Science Translational Medicine. 15
Autoimmune toxicity occurs in up to 60% of patients treated with immune checkpoint inhibitor (ICI) therapy for cancer and represents an increasing clinical challenge for expanding the use of these treatments. To date, human immunopathogenic studies o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ce42b30f8c2be1ed85e4d4e193acd35
https://doi.org/10.1126/scitranslmed.adg0675
https://doi.org/10.1126/scitranslmed.adg0675
PDF file - 2957K, Supplementary Figure 1. Increased autoantibodies to B16 melanoma extract and decreased B16 melanoma growth in Aire-deficient mice. Supplementary Figure 2. Increased frequency of activated/memory T cells in Aire-deficient mice inocul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba37703e8349e0dc6dc6c331bb4c6b9b
https://doi.org/10.1158/0008-5472.22400138
https://doi.org/10.1158/0008-5472.22400138
The thymic transcription factor autoimmune regulator (Aire) prevents autoimmunity in part by promoting expression of tissue-specific self-antigens, which include many cancer antigens. For example, AIRE-deficient patients are predisposed to vitiligo,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f69173406ee1e511df643e2851029ee
https://doi.org/10.1158/0008-5472.c.6505508
https://doi.org/10.1158/0008-5472.c.6505508
Autor:
Meng-Lei Zhu, Pearl Bakhru, Bridget Conley, Jennifer S. Nelson, Meghan Free, Aaron Martin, Joshua Starmer, Elizabeth M. Wilson, Maureen A. Su
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Males are less susceptible to autoimmune diseases due to immunomodulatory effects of androgen. Here the authors show that androgen receptor upregulates Aire and Aire-dependent transcription in the thymic epithelium, and that Aire is required for andr
Externí odkaz:
https://doaj.org/article/1221cac6180d456f84a5102f730cd069
Autor:
Zoe Quandt, Stephanie Kim, Javier Villanueva-Meyer, Catherine Coupe, Arabella Young, Jee Hye Kang, Jinoos Yazdany, Gabriela Schmajuk, Stephanie Rush, Elad Ziv, Ana Luisa Perdigoto, Kevan Herold, Melissa G Lechner, Maureen A Su, J Blake Tyrrell, Jeffrey Bluestone, Mark Anderson, Umesh Masharani
Publikováno v:
Journal of the Endocrine Society, vol 7, iss 4
ContextHypophysitis is a known immune-related adverse event (irAE) of immune checkpoint inhibitors (CPIs), commonly associated with CTLA-4 inhibitors and less often with PD-1/PD-L1 inhibitors.ObjectiveWe aimed to determine clinical, imaging, and HLA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba46cdfcfc3faa16ca44a35c1570f80
https://doi.org/10.1210/jendso/bvad012
https://doi.org/10.1210/jendso/bvad012
Autor:
Lizhong Ding, Lu Sun, Melissa T. Bu, Yanjun Zhang, Lauren N. Scott, Robert M. Prins, Maureen A. Su, Melissa G. Lechner, Willy Hugo
The mechanism by which ICI (immune checkpoint inhibitor) induce durable antitumor T cell activity remains inadequately defined. Tumors from melanoma patients who responded to ICI or MAPK pathway inhibitors (MAPKi) therapy generally displayed increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6592b2e5c666c1a9c009ae22684cec39
https://doi.org/10.1101/2022.12.08.519660
https://doi.org/10.1101/2022.12.08.519660
Autor:
Mandy I. Cheng, Luke Riggan, Joey H. Li, Rana Yakhshi Tafti, Scott Chin, Feiyang Ma, Matteo Pellegrini, Haley Hrncir, Arthur P. Arnold, Timothy E. O’Sullivan, Maureen A. Su
Viral infection outcomes are sex-biased, with males generally more susceptible than females. Paradoxically, the numbers of anti-viral natural killer (NK) cells are increased in males compared to females. Using samples from mice and humans, we demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dfc5d04a50e0fd6655bccd33eaa85ee
https://doi.org/10.1101/2022.04.21.489076
https://doi.org/10.1101/2022.04.21.489076
Publikováno v:
Annual review of immunology, vol 40, iss 1
Annu Rev Immunol
Annu Rev Immunol
Strong epidemiological evidence now exists that sex is an important biologic variable in immunity. Recent studies, for example, have revealed that sex differences are associated with the severity of symptoms and mortality due to coronavirus disease 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592a1d6ef1ab76c6f19e4274a1b72306
https://escholarship.org/uc/item/0d1975h3
https://escholarship.org/uc/item/0d1975h3
Autor:
Melissa G. Lechner, Anushi Y. Patel, Willy Hugo, Trevor E. Angell, Mandy I. Cheng, Marissa S. Pioso, Aline T. Hoang, Natalie Yakobian, Ethan C. McCarthy, Ho-Chung Chen, Eduardo D. Rodriguez, Lily Guo, Michael Astourian, Alexandra Drakaki, Pouyan Famini, Antoni Ribas, Maureen A. Su
Checkpoint inhibitor (ICI) immunotherapy leverages the body’s own immune system to attack cancer cells but leads to unwanted autoimmune side effects in up to 60% of patients. Such immune related adverse events (IrAE) may lead to treatment interrupt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cc5dd018620224cf8c8d8463725d292
https://doi.org/10.1101/2022.01.19.476844
https://doi.org/10.1101/2022.01.19.476844