Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Maureen A, Nickols"'
Autor:
Amol Karwa, Bethel Asmelash, Kimberly R. Gaston, Carolyn J. Sympson, John N. Freskos, Bich Vu, Tim A. Marzan, Tasha M. Schoenstein, Thomas Rogers, Maureen A. Nickols
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5566-5570
We describe the synthesis, MMP-2 and 9 potency, and in vitro evaluation of a series of α-sulfone hydroxmate MMP inhibitors conjugated to a series of dyes with different absorption/emission lamina maxima's that can be used to visualize tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b998d181d5181c6b9271d7d8ff37ed
https://doi.org/10.1016/j.bmcl.2013.08.050
https://doi.org/10.1016/j.bmcl.2013.08.050
Autor:
James W. Malecha, Christina N. Steininger, Melanie L. Williams, Kristen E. Shannon, Thomas Rogers, Bryan H. Landis, Tiffany Duffin, Srinivasan Nagarajan, Pegg Jodi Ann, Hwang-Fun Lu, Rico Joseph G, Maureen A. Nickols, Jun Zhu, Sandra K. Freeman, V. Wayne Engleman, David W. Griggs, G. Alan Nickols, Jeffery L. Keene, Devadas Balekudru, Debra M. Meyer, Marisa M. Westlin, Larry Miller, Laura D. Marrufo, Nawasa F. Green, Melissa K. Lantz, Mark A. Russell, Peter G. Ruminski, Mary Beth Finn, H. Peter Kleine, Joe T. Collins
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3783-3800
The integrin αvβ3, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discovery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d38d74f8d90c225cd3716f76ef91f6
https://doi.org/10.1016/j.bmc.2007.03.034
https://doi.org/10.1016/j.bmc.2007.03.034
Autor:
Srinivasan Nagarajan, Ish K. Libertyville Khanna, Tiffany Duffin, Alan F. Gasiecki, Jeffery L. Keene, Mihir D. Parikh, Michael Clare, Marisa M. Westlin, Maureen A. Nickols, Christina A. Steininger, Melanie L. Williams, Hwang-Fun Lu, Thomas Rogers, Jon A. Klover, Mary Beth Finn, V. Wayne Engleman, Sandra K. Freeman, William F. Westlin, Barbara B. Chen, G. Alan Nickols, Kristen E. Shannon, Mark A. Russell, Bipinchandra N. Desai
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3390-3412
The integrin alpha(v)beta(3) is expressed in a number of cell types and is thought to play a major role in several pathological conditions. Various small molecules that inhibit the integrin have been shown to suppress tumor growth and retinal angioge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76977820b693cad5d5c26a6da2d6f596
https://doi.org/10.1016/j.bmc.2007.03.020
https://doi.org/10.1016/j.bmc.2007.03.020
Autor:
Tiffany Duffin, Maureen A. Nickols, Barbara B. Chen, Mary Beth Finn, Mark A. Russell, William F. Westlin, Steven L. Settle, Mark L. Boys, Randall K. Rader, Jon A. Klover, Wang Yaping, Thomas D. Penning, Jeffery L. Keene, V. Wayne Engleman, G. Allen Nickols, Christina N. Steininger, Sandra K. Freeman, Melanie L. Hanneke, Khilevich Albert, Marisa M. Westlin, Kristen E. Shannon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3156-3161
We describe a series of pyrazole and isoxazole analogs as antagonists of the α v β 3 receptor. Compounds showed low to sub-nanomolar potency against α v β 3 , as well as good selectivity against α IIb β 3 . In HT29 cells, most analogs also demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e27cd8fc7dca2f6785f6b7c08e8bda4
https://doi.org/10.1016/j.bmcl.2006.03.045
https://doi.org/10.1016/j.bmcl.2006.03.045
Autor:
Mary Beth Finn, Hongwei Wu, Kristen E. Shannon, V. Wayne Engleman, Maureen A. Nickols, Jon A. Klover, Marissa Westlin, Tiffany Duffin, Christina N. Steininger, G. Allen Nickols, Thomas D. Penning, Melanie L. Hanneke, John A. Wendt, Heather Stenmark, Mark A. Russell, Jeffery L. Keene, Downs Victoria Leigh, William F. Westlin, Barbara B. Chen, Wang Yaping, Sandra K. Freeman, Mark L. Boys
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:845-849
We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha(v)beta3 and show selectivity relative to the other integrins, such as alpha(IIb)beta3 and alpha(v)beta6. These analogs were demonstrated to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9341668d602c5606e629cc594893da77
https://doi.org/10.1016/j.bmcl.2005.11.017
https://doi.org/10.1016/j.bmcl.2005.11.017
Autor:
Christopher R. Dalton, Nizal S. Chandrakumar, Mark L. Boys, G. Allen Nickols, Mark Russell, Maureen A. Nickols, Michael Clare, Dale P. Spangler, John A. Wendt, Christina N. Steininger, William F. Westlin, Yaping Wang, Tiffany Duffin, Michael B. Tollefson, Jon A. Klover, Sandra K. Freeman, Melanie L. Hanneke, Scott B. Mohler, Mary Beth Finn, Maria N. Nguyen, Heather G. Stenmark, Jeffery L. Keene, Hongwei Wu, Bipin N. Desai, Barbara B. Chen, V. Wayne Engleman, Yi X. Yu, Sarah A. Norring, Marisa M. Westlin, Lori A. Schretzman, Downs Victoria Leigh, Ish K. Khanna, Thomas D. Penning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:839-844
We describe a series of 1,2,4-oxadiazoles, which are potent antagonists of the integrin alpha(v)beta3 and, in addition, show selectivity relative to the other beta3 integrin alpha(IIb)beta3. In whole cells, the majority of these analogs also demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701f9513e934e8bf576a289475c31d0e
https://doi.org/10.1016/j.bmcl.2005.11.008
https://doi.org/10.1016/j.bmcl.2005.11.008
Publikováno v:
Journal of Bone and Mineral Research. 5:353-359
Binding of 125I-labeled rat (r) PTH-(1-34) to ROS 17/2.8 osteoblastic bone cells and to membranes from these cells was examined. Competitive binding inhibition experiments were performed using unlabeled rPTH-(1-34) with particular emphasis on concent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9922cac29e65b41043fca2e663217db
https://doi.org/10.1002/jbmr.5650050408
https://doi.org/10.1002/jbmr.5650050408
Autor:
Jaime L. Masferrer, James K. Gierse, Karen Seibert, Kathleen M. Leahy, Jeffery S. Carter, Yan Zhang, Luz A. Cortes-Burgos, James D. Warner, Maureen A. Nickols
Publikováno v:
European journal of pharmacology. 588(1)
A new class of selective cyclooxygenase-2 (COX-2) inhibitors has been identified by high throughput screening. Structurally distinct from previously described selective COX-2 inhibitors, these benzopyrans contain a carboxylic acid function and CF3 fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404e3f08678519dfeb56a655b67c88fd
https://pubmed.ncbi.nlm.nih.gov/18457826
https://pubmed.ncbi.nlm.nih.gov/18457826
Autor:
Srinivasan R, Nagarajan, Balekudru, Devadas, James W, Malecha, Hwang-Fun, Lu, Peter G, Ruminski, Joseph G, Rico, Thomas E, Rogers, Laura D, Marrufo, Joe T, Collins, H Peter, Kleine, Melissa K, Lantz, Jun, Zhu, Nawasa F, Green, Mark A, Russell, Bryan H, Landis, Lawrence M, Miller, Debra M, Meyer, Tiffany D, Duffin, V Wayne, Engleman, Mary B, Finn, Sandra K, Freeman, David W, Griggs, Melanie L, Williams, Maureen A, Nickols, Jodi A, Pegg, Kristen E, Shannon, Christina, Steininger, Marisa M, Westlin, G Alan, Nickols, Jeffery L, Keene
Publikováno v:
Bioorganicmedicinal chemistry. 15(11)
The integrin alpha(v)beta(3), vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a0bd91c9e67f6a65c308d5b53b9f248
https://pubmed.ncbi.nlm.nih.gov/17399986
https://pubmed.ncbi.nlm.nih.gov/17399986
Autor:
Thomas D, Penning, Albert, Khilevich, Barbara B, Chen, Mark A, Russell, Mark L, Boys, Yaping, Wang, Tiffany, Duffin, V Wayne, Engleman, Mary Beth, Finn, Sandra K, Freeman, Melanie L, Hanneke, Jeffery L, Keene, Jon A, Klover, G Allen, Nickols, Maureen A, Nickols, Randall K, Rader, Steven L, Settle, Kristen E, Shannon, Christina N, Steininger, Marisa M, Westlin, William F, Westlin
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(12)
We describe a series of pyrazole and isoxazole analogs as antagonists of the alpha(v)beta3 receptor. Compounds showed low to sub-nanomolar potency against alpha(v)beta3, as well as good selectivity against alpha(IIb)beta3. In HT29 cells, most analogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b85efae80aa2dd097353fe9524af3756
https://pubmed.ncbi.nlm.nih.gov/16621534
https://pubmed.ncbi.nlm.nih.gov/16621534