Data from Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1α Expression in an AhR-Independent Fashion

Autor: Giovanni Melillo, Marina Ziche, Angelika M. Burger, Liang Cao, Badarch Uranchimeg, Annamaria Rapisarda, Maura Puppo, Erika Terzuoli

Aminoflavone (AF), the active component of a novel anticancer agent (AFP464) in phase I clinical trials, is a ligand of the aryl hydrocarbon receptor (AhR). AhR dimerizes with HIF-1β/AhR, which is shared with HIF-1α, a transcription factor critical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8e3a416e3dfc8c05c626bc44048506
https://doi.org/10.1158/0008-5472.c.6500886

Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1α and -2α

Autor: Catherine Ottaviano, Silvana Delfino, Maura Puppo, Luigi Varesio, Domenico Ribatti, Maria Carla Bosco, Florinda Battaglia

Publikováno v: Molecular Cancer Therapeutics. 7:1974-1984

Neuroblastoma produce angiogenic peptides, and the extent of angiogenesis correlates with tumor progression and poor clinical outcome. Hence, angiogenic factor inhibition represents an important therapeutic option. One of the major drives to tumor an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7c9fea7f010ec340077211152a4175
https://doi.org/10.1158/1535-7163.mct-07-2059

Hypoxia Selectively Inhibits Monocyte Chemoattractant Protein-1 Production by Macrophages

Autor: Maura Puppo, Annamaria Rapisarda, Zenghui Mi, Stefano Massazza, Sandra Pastorino, Giovanni Melillo, Maria Carla Bosco, Luigi Varesio

Publikováno v: The Journal of Immunology. 172:1681-1690

Hypoxia, a local decrease in oxygen tension occurring in inflammatory and tumor lesions, modulates gene expression in macrophages. Because macrophages are important chemokine producers, we investigated the regulatory effects of hypoxia on macrophage-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663322eee528833cfff0a5e56554196c
https://doi.org/10.4049/jimmunol.172.3.1681

A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients

Autor: Ingrid Øra, Paolo Fardin, Luigi Varesio, Alessandro Verri, Jan J. Molenaar, Lorenzo Rosasco, Maura Puppo, Annalisa Barla, Alessandra Eva, Sofia Mosci, Huib N. Caron, Rogier Versteeg

Publikováno v: Molecular Cancer, 9(1). BioMed Central
Molecular Cancer, Vol 9, Iss 1, p 185 (2010)
BioMed Central
Molecular Cancer
Molecular cancer, 9(1). BioMed Central

Background Hypoxia is a condition of low oxygen tension occurring in the tumor microenvironment and it is related to poor prognosis in human cancer. To examine the relationship between hypoxia and neuroblastoma, we generated and tested an in vitro de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2dd819b5c180bb01c2a38404ec3200
https://dare.uva.nl/personal/pure/en/publications/a-biologydriven-approach-identifies-the-hypoxia-gene-signature-as-a-predictor-of-the-outcome-of-neuroblastoma-patients(2c31d3fe-b1fd-4d35-a82f-f33558e88c91).html

Hypoxic synovial environment and expression of macrophage inflammatory protein 3gamma/CCL20 in juvenile idiopathic arthritis

Autor: Marco Gattorno, Silvana Delfino, Francesca Ferlito, Maura Puppo, Florinda Battaglia, Claudio Gambini, Maria Carla Bosco, Andrea Gregorio, Luigi Varesio, Alberto Martini

Publikováno v: Arthritis and rheumatism. 58(6)

Objective Synovial inflammation is a major determinant of juvenile idiopathic arthritis (JIA) pathogenesis and is mediated by local chemokine secretion. Monocytic cells are an important source of chemokines. The purpose of this study was to investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9825adf433fada6c93ea31dfba6bcc2a
https://pubmed.ncbi.nlm.nih.gov/18512817