Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Maurício Temotheo TAVARES"'
Autor:
Maurício Temotheo TAVARES, Luiza Silva FERREIRA, Marina Candido PRIMI, Jeanine GIAROLLA, Roberto PARISE-FILHO
Publikováno v:
Infarma: Pharmaceutical Sciences, Vol 30, Iss 3, Pp 168-177 (2018)
A internacionalização do ensino superior foi incorporada às diretrizes das universidades brasileiras e estágios no exterior são bons exemplos desta medida. Nos últimos anos, a procura por estágios internacionais tem aumentado, porém, a litera
Externí odkaz:
https://doaj.org/article/c24edfd5f1284124a4a15defedb9cb3d
Autor:
Micael Rodrigues Cunha, Maurício Temotheo Tavares, Thais Batista Fernandes, Roberto Parise-Filho
Publikováno v:
Molecules, Vol 26, Iss 6, p 1521 (2021)
Piper, Capsicum, and Pimenta are the main genera of peppers consumed worldwide. The traditional use of peppers by either ancient civilizations or modern societies has raised interest in their biological applications, including cytotoxic and antiproli
Externí odkaz:
https://doaj.org/article/a72d8e63def04251883a34134e3d7100
Autor:
Maurício Temotheo Tavares, Marina Candido Primi, Camila Felix de Carvalho, Michelle Carneiro Polli, Roberto Parise-Filho
Publikováno v:
Química Nova, Vol 39, Iss 4, Pp 502-506 (2016)
Cholesterol is a lipid which in high concentration can be an important risk factor for coronary diseases and atherosclerotic lesions. This lipid presents an endogenous biosynthesis that involves several steps; one of them is modulated by the enzyme 3
Externí odkaz:
https://doaj.org/article/292b7055b54b435abd76a90c1f07d66c
Autor:
Maurício Temotheo Tavares, Marina Candido Primi, Michelle Carneiro Polli, Elizabeth Igne Ferreira, Roberto Parise-Filho
Publikováno v:
Química Nova, Vol 38, Iss 8, Pp 1117-1124 (2015)
Teaching classes and events regarding the molecular aspects of drug-receptor interactions is not an easy task. The ligand stereochemistry and the spatial arrangement of the macromolecular targets highly increase the complexity of the process. In this
Externí odkaz:
https://doaj.org/article/21300c14ef29497792094341c06842d3
Autor:
Otávio Augusto Chaves, Maurício Temotheo Tavares, Micael Rodrigues Cunha, Roberto Parise-Filho, Carlos Maurício R. Sant’Anna, José Carlos Netto-Ferreira
Publikováno v:
Biomolecules, Vol 8, Iss 3, p 78 (2018)
The interaction between the main carrier of endogenous and exogenous compounds in the human bloodstream (human serum albumin, HSA) and a potential anticancer compound (the capsaicin analogue RPF101) was investigated by spectroscopic techniques (circu
Externí odkaz:
https://doaj.org/article/d7489665ccd44e9988256e2aad039f86
Autor:
Richard B. Silverman, Peter F. Doubleday, Neil L. Kelleher, Glaucio Monteiro Ferreira, Arseniy Butrin, Sida Shen, Maurício Temotheo Tavares, Graham R. Moran, Dali Liu, Brett A. Beaupre, Rafael D. Melani
Publikováno v:
Journal of the American Chemical Society. 143:8689-8703
The inhibition of human ornithine δ-aminotransferase (hOAT) is a potential therapeutic approach to treat hepatocellular carcinoma. In this work, (S)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (SS-1-148, 6) was identified as a potent mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a75c4c6fd27c268752b7359816fc551
https://doi.org/10.1021/jacs.1c02456
https://doi.org/10.1021/jacs.1c02456
Autor:
Sida Shen, Maurício Temotheo Tavares
Publikováno v:
Future Medicinal Chemistry. 13:1017-1019
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1ef03cfbb22a01b3f7810e0c331957
https://doi.org/10.4155/fmc-2021-0040
https://doi.org/10.4155/fmc-2021-0040
Autor:
Zsofia Kutil, Brett Langley, Veronick Benoy, Sida Shen, Cristina Picci, Cyril Bařinka, Matthew B. Robers, Ludo Van Den Bosch, Alan P. Kozikowski, Jiří Pavlíček, Chad Zimprich, Guiping Zhang, Kseniya Ustinova, Maurício Temotheo Tavares
Publikováno v:
Journal of medicinal chemistry. 64(8)
Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eecb9ca5026a2d98cc63517f1fb871d
https://pubmed.ncbi.nlm.nih.gov/33830764
https://pubmed.ncbi.nlm.nih.gov/33830764
Autor:
Letícia V. Costa-Lotufo, Thainá Fujii de Divitiis, Mônica Franco Zannini Junqueira Toledo, Roberto Parise-Filho, Neuza Mariko Aymoto Hassimotto, Glaucio Monteiro Ferreira, Thales Kronenberger, Maurício Temotheo Tavares, Larissa Costa de Almeida, João Agostinho Machado-Neto
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Histone deacetylases (HDACs) are a family of enzymes that modulate the acetylation status histones and non-histone proteins. Histone deacetylase inhibitors (HDACis) have emerged as an alternative therapeutic approach for the treatment of several mali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bae43f7efd55799e86002dfb4e4df0
Autor:
Melissa Hadley, Alejandro Villagra, Alan P. Kozikowski, Jakub Ptacek, Guiping Zhang, Guido Pelaez, Satish Noonepalle, Cyril Bařinka, Sida Shen, Glaucio Monteiro Ferreira, Jiří Pavlíček, Jan Stránský, Maurício Temotheo Tavares
Publikováno v:
Journal of medicinal chemistry. 63(18)
Selective inhibition of histone deacetylase 6 (HDAC6) is being recognized as a therapeutic approach for cancers. In this study, we designed a new HDAC6 inhibitor, named Suprastat, using in silico simulations. X-ray crystallography and molecular dynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1067eb012c9747bd2d8f485347a249
https://pubmed.ncbi.nlm.nih.gov/32815366
https://pubmed.ncbi.nlm.nih.gov/32815366