Výsledky vyhledávání - "Maurício S. dos Santos"

Synthesis of 5-amino-1-aryl-3-methyl-1H-pyrazole-4-carbonitriles, Antifungal Activity and In Silico Analysis

Autor: Jéssica V. Faria, Helena Carla Castro, Maurício S. dos Santos, Paula Alvarez Abreu, Alice M. R. Bernardino, Rômulo Gabriel De Miranda de Paula Pinto, Daiane de Jesus Viegas, Luciana Terra, Percilene Fazolin Vegi

Publikováno v: Letters in Organic Chemistry. 17:779-787

Serious fungal infections are increasing worldwide and have become a great concern in the medical field since antifungal drugs are restricted to a few drug classes. This work aims to evaluate the antifungal activity of a series of 5-amino-1-aryl-3-me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c3e9c15accabc519e17120d8ff8293d
https://doi.org/10.2174/1570178617666200210105246

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Structural Optimization and Biological Activity of Pyrazole Derivatives: Virtual Computational Analysis, Recovery Assay and 3D Culture Model as Potential Predictive Tools of Effectiveness against Trypanosoma cruzi

Autor: Guilherme C. Lechuga, Maurício S. dos Santos, Byanca Silva Ferreira, Cynthia Nathalia Pereira, Rafaela Corrêa Silva, Leonardo da Silva Lara, Lorraine Martins Rocha Orlando, Mirian Claudia de Souza Pereira

Publikováno v: Molecules
Volume 26
Issue 21
Molecules, Vol 26, Iss 6742, p 6742 (2021)

Chagas disease, a chronic and silent disease caused by Trypanosoma cruzi, is currently a global public health problem. The treatment of this neglected disease relies on benznidazole and nifurtimox, two nitroheterocyclic drugs that show limited effica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be89cb2562a37be251f8984b917e3bf6
https://doi.org/10.3390/molecules26216742

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Pyrazolyl-Tetrazoles and Imidazolyl-Pyrazoles as Potential Anticoagulants and their Integrated Multiplex Analysis Virtual Screening

Autor: Robson Q. Monteiro, Jéssica V. Faria, Percilene Fazolin Vegi, André Luiz Lourenço, Tatiana P. Dutra, Alice M. R. Bernardino, Carlos Rangel Rodrigues, Max Seidy Saito, Marcos Vinicius Santana, Helena Carla Castro, Maurício S. dos Santos, Plínio Cunha Sathler, Gustavo S. P. Pinto

Publikováno v: Journal of the Brazilian Chemical Society.

This article reports a novel virtual screening algorithm seeking the rational identification of novel lead anticoagulants. Seven 5-(3-methyl-1-aryl-1H-pyrazol-4-yl)-1H-tetrazoles and seven novel 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-3-methyl-1H-pyr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38073437b745f091fba2a701f9d8db59
https://doi.org/10.21577/0103-5053.20180150

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Recently reported biological activities of pyrazole compounds

Autor: Maurício S. dos Santos, Ana Gabriella Carvalho Miguita, Alice M. R. Bernardino, Nubia Boechat, Jéssica V. Faria, Percilene Fazolin Vegi

Publikováno v: Bioorganicmedicinal chemistry. 25(21)

The pyrazole nucleus is an aromatic azole heterocycle with two adjacent nitrogen atoms. Pyrazole derivatives have exhibited a broad spectrum of biological activities, and approved pyrazole-containing drugs include celecoxib, antipyrine, phenylbutazon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d936b0dca16c901c9bd0d3f6f7cf1372
https://pubmed.ncbi.nlm.nih.gov/28988624

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The New Pyrazolyltetrazole Derivative MSN20 Is Effective via Oral Delivery against Cutaneous Leishmaniasis

Autor: Eduardo Caio Torres-Santos, Maurício S. dos Santos, Viviane dos Santos Faiões, Edézio Ferreira Cunha-Júnior, Marilene Marcuzzo do Canto Cavalheiro, Alice M. R. Bernardino

Publikováno v: Antimicrobial Agents and Chemotherapy. 58:6290-6293

An orally delivered, safe and effective treatment for leishmaniasis is an unmet medical need. Azoles and the pyrazolylpyrimidine allopurinol present leishmanicidal activity, but their clinical efficacies are variable. Here, we describe the activity o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38f12dfe5eda9bf77d44e69918e683b
https://doi.org/10.1128/aac.02874-14

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An Efficient Synthesis of New 5-(1-Aryl-1H-pyrazole-4-yl)-1H-tetrazoles from 1-Aryl-1H-pyrazole-4-carbonitrilesvia[3 + 2] Cycloaddition Reaction

Autor: Marilene M. Canto-Cavalheiro, Maurício S. dos Santos, Leonor L. Leon, Luiz C. S. Pinheiro, Alice M. R. Bernardino

Publikováno v: Journal of Heterocyclic Chemistry. 49:1425-1428

A series of new 5-(1-aryl-1H-pyrazole-4-yl)-1H-tetrazoles 4a-l were synthesized via [3 + 2] cycloaddition reaction from 1-aryl-1H-pyrazole-4-carbonitriles 3a-l, sodium azide and ammonium chloride, using dimethylformamide (DMF) as solvent, in good yie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3dc85290d611c4aa245921f07806f3b
https://doi.org/10.1002/jhet.928

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Synthesis and activity of novel tetrazole compounds and their pyrazole-4-carbonitrile precursors against Leishmania spp

Autor: Maurício S. dos Santos, Alice M. R. Bernardino, Klaus M. Becker, Marilene M. Canto-Cavalheiro, Leonor L. Leon, Gerzia M. C. Machado, Jéssica V. Faria, Raquel Fonseca Rodrigues

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:6310-6312

A new series of 5-(1-aryl-3-methyl-1H-pyrazol-4-yl)-1H-tetrazole derivatives (4a-m) and their precursor 1-aryl-3-methyl-1H-pyrazole-4-carbonitriles (3a-m) were synthesized and evaluated as antileishmanials against Leishmania braziliensis and Leishman

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84320c45d9c6704fd6f45ad2a075c5bd
https://doi.org/10.1016/j.bmcl.2013.09.062

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