Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Maurício Rocha-Martins"'
Autor:
Gabriel E. Matos-Rodrigues, Pedro B. Tan, Maurício Rocha-Martins, Clara F. Charlier, Anielle L. Gomes, Felipe Cabral-Miranda, Paulius Grigaravicius, Thomas G. Hofmann, Pierre-Olivier Frappart, Rodrigo A. P. Martins
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 10 (2020)
Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress response, the mutu
Externí odkaz:
https://doaj.org/article/bb33c090dc6e4230a90edb6589fa1b1b
Autor:
MAURÍCIO ROCHA-MARTINS, GABRIEL R. CAVALHEIRO, GABRIEL E. MATOS-RODRIGUES, RODRIGO A.P. MARTINS
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 87, Iss 2 suppl, Pp 1323-1348 (2015)
ABSTRACTGenome modification technologies are powerful tools for molecular biology and related areas. Advances in animal transgenesis and genome editing technologies during the past three decades allowed systematic interrogation of gene function that
Externí odkaz:
https://doaj.org/article/aa72be30e2624c50b5ea9ee364ee9445
Autor:
Paulo M. G. Rodrigues, Paulius Grigaravicius, Martina Remus, Gabriel R. Cavalheiro, Anielle L. Gomes, Maurício Rocha-Martins, Lucien Frappart, David Reuss, Peter J. McKinnon, Andreas von Deimling, Rodrigo A. P. Martins, Pierre-Olivier Frappart
Publikováno v:
PLoS ONE, Vol 8, Iss 8 (2013)
Externí odkaz:
https://doaj.org/article/d4d6856a2ea942ffaf0a211991b3dec6
Autor:
Paulo M G Rodrigues, Paulius Grigaravicius, Martina Remus, Gabriel R Cavalheiro, Anielle L Gomes, Maurício Rocha-Martins, Lucien Frappart, David Reuss, Peter J McKinnon, Andreas von Deimling, Rodrigo A P Martins, Pierre-Olivier Frappart
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69209 (2013)
Nibrin (NBN or NBS1) and ATM are key factors for DNA Double Strand Break (DSB) signaling and repair. Mutations in NBN or ATM result in Nijmegen Breakage Syndrome and Ataxia telangiectasia. These syndromes share common features such as radiosensitivit
Externí odkaz:
https://doaj.org/article/1f7dacd6af75412a94f5205780fff290
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43028 (2012)
BACKGROUND: Housekeeping genes have been commonly used as reference to normalize gene expression and protein content data because of its presumed constitutive expression. In this paper, we challenge the consensual idea that housekeeping genes are rel
Externí odkaz:
https://doaj.org/article/ff20608fcd354738850c13cadddfbf5f
Autor:
Caren Norden, Christoph Zechner, Elisa Nerli, Tommaso Bianucci, Jenny Kretzschmar, Maurício Rocha-Martins
SummaryCorrect nervous system development depends on the timely differentiation of progenitor cells into neurons. While the output of progenitor differentiation is well investigated at the population and clonal level, the possibilities and constraint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d0c5c201f3f176f0fba5b66bed38e91
https://doi.org/10.1101/2022.08.11.503564
https://doi.org/10.1101/2022.08.11.503564
Autor:
Maurício Rocha-Martins
Publikováno v:
Development. 146
Retinal ganglion cells connect the retina to the brain, and their degeneration underlies glaucoma, which is the leading cause of irreversible blindness in humans and currently untreatable. Replacement of lost cells could be achieved by in vivo reprog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd481d062f5f39e65d37df0065a6cad
https://doi.org/10.1242/dev.182998
https://doi.org/10.1242/dev.182998
Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway
Publikováno v:
eLife, Vol 9 (2020)
During brain development, progenitor cells need to balanceproliferation and differentiation in order to generate different neurons in the correct numbers and proportions. Currently, the patterns of multipotent progenitor divisions that lead to neurog
Externí odkaz:
https://doaj.org/article/a8aeb3f98235463d9dbed438a01236cf
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2018)
In the retina, like in most other brain regions, developing neurons are arranged into distinct layers giving the mature tissue its stratified appearance. This process needs to be highly controlled and orchestrated, as neuronal layering defects lead t
Externí odkaz:
https://doaj.org/article/6abba82d57d04a5d88e56377690b5482