A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells.

Autor: Jonatan Ersching, Alexandre Salgado Basso, Vera Lucia Garcia Kalich, Karina Ramalho Bortoluci, Maurício M Rodrigues

Publikováno v: PLoS Pathogens, Vol 12, Iss 6, p e1005698 (2016)

Although CD4+ Foxp3+ T cells are largely described in the regulation of CD4+ T cell responses, their role in the suppression of CD8+ T cell priming is much less clear. Because the induction of CD8+ T cells during experimental infection with Trypanoso

Externí odkaz: https://doaj.org/article/bf23b7099f3d425da6796448541b8875

Influence of HLA-DRB1 and HLA-DQB1 alleles on IgG antibody response to the P. vivax MSP-1, MSP-3α and MSP-9 in individuals from Brazilian endemic area.

Autor: Josué C Lima-Junior, Rodrigo N Rodrigues-da-Silva, Dalma M Banic, Jianlin Jiang, Balwan Singh, Gustavo M Fabrício-Silva, Luís C S Porto, Esmeralda V S Meyer, Alberto Moreno, Maurício M Rodrigues, John W Barnwell, Mary R Galinski, Joseli de Oliveira-Ferreira

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36419 (2012)

The antibody response generated during malaria infections is of particular interest, since the production of specific IgG antibodies is required for acquisition of clinical immunity. However, variations in antibody responses could result from genetic

Externí odkaz: https://doaj.org/article/37a24914274645be918442b9e539e264

Rapamycin Improves the Response of Effector and Memory CD8+ T Cells Induced by Immunization With ASP2 of Trypanosoma cruzi

Autor: Barbara Ferri Moraschi, Isaú Henrique Noronha, Camila Pontes Ferreira, Leonardo M. Cariste, Caroline B. Monteiro, Priscila Denapoli, Talita Vrechi, Gustavo J. S. Pereira, Ricardo T. Gazzinelli, Joseli Lannes-Vieira, Maurício M. Rodrigues, Karina R. Bortoluci, José Ronnie C. Vasconcelos

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Deficiency in memory formation and increased immunosenescence are pivotal features of Trypanosoma cruzi infection proposed to play a role in parasite persistence and disease development. The vaccination protocol that consists in a prime with plasmid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be42c262a88dc45ba2eae5453d84913
https://doi.org/10.3389/fcimb.2021.676183

Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice

Autor: Mauricio M Rodrigues, Bruna C de Alencar, Carla Claser, Fanny Tzelepis, Eduardo L Silveira, Filipe A Haolla, Mariana R Dominguez, José Ronnie Vasconcelos

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 104, Pp 281-287 (2009)

Vaccines have had an unquestionable impact on public health during the last century. The most likely reason for the success of vaccines is the robust protective properties of specific antibodies. However, antibodies exert a strong selective pressure

Externí odkaz: https://doaj.org/article/773fd2cec4f64c27ba1349ee03470d98

Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax

Autor: Mayara B Barbedo, Ricardo Ricci, Maria Carolina S Jimenez, Maristela G Cunha, Syed S Yazdani, Chetan E Chitnis, Mauricio M Rodrigues, Irene S Soares

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 102, Iss 3, Pp 335-340 (2007)

In previous immuno-epidemiological studies of the naturally acquired antibody responses to merozoite surface protein-1 (MSP-1) of Plasmodium vivax, we had evidence that the responses to distinct erythrocytic stage antigens could be differentially reg

Externí odkaz: https://doaj.org/article/ad787abe30e94f8ab6f7697f993d20e1