Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Maulik N. Thaker"'
Autor:
Venkateswarlu Yarlagadda, Georgina Cox, Timothy A. Johnson, Gerard D. Wright, Maulik N. Thaker, Ricardo Medina, Kalinka Koteva
Publikováno v:
ACS infectious diseases. 6(12)
The rise of bacterial antibiotic resistance coupled with a diminished antibiotic drug pipeline underlines the importance of developing rational strategies to discover new antimicrobials. Microbially derived natural products are the basis for most of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599b6c6f950f625ba56aa1c6f3fb1c00
https://pubmed.ncbi.nlm.nih.gov/33164482
https://pubmed.ncbi.nlm.nih.gov/33164482
Autor:
Amir Florentin, Daniela Rotin, Jeremiah Lilly, Martin Kupiec, Maulik N. Thaker, Shira kadosh, Kobi J. Simpson-Lavy, Gali Prag, Anna Shusterman, Alina Kordonsky, Sivan Elias, Bar Manori, Mor Sror, Tal Marshanski, Reut Avishid, Elon Yariv, Victor Tarabykin, Ofir Almog, Olga Levin-Kravets, Mateusz C. Ambrozkiewicz, Nicole Ben David, Sagnik Biswas, Zohar Fischer, Yael Langut, Avinash Persaud, Ekaterina Borisova
Publikováno v:
Journal of Molecular Biology. 433:167276
Split reporter protein-based genetic section systems are widely used to identify and characterize protein–protein interactions (PPI). The assembly of split markers that antagonize toxins, rather than required for synthesis of missing metabolites, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd9b1ae094a85162bdc3220894d7cbb
https://doi.org/10.1016/j.jmb.2021.167276
https://doi.org/10.1016/j.jmb.2021.167276
Autor:
Donald E. Low, Maulik N. Thaker, Alireza Eshaghi, Allison McGeer, Susan M. Poutanen, Barbara M. Willey, Bryan Coburn, Lindsay Kalan, Gerard D. Wright, Samir N. Patel, Nicholas Waglechner
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:1405-1410
Vancomycin-resistant enterococci (VRE) are notorious clinical pathogens restricting the use of glycopeptide antibiotics in the clinic setting. Routine surveillance to detect VRE isolated from patients relies on PCR bioassays and chromogenic agar-base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd193cbc0d383b5ddef99ca68a5a29f
https://doi.org/10.1128/aac.04490-14
https://doi.org/10.1128/aac.04490-14
Autor:
Nicholas Waglechner, Xi Ming Zhu, Gerard D. Wright, Maulik N. Thaker, David L. Zechel, Lindsay Kalan, Andreas Bechthold, Arne Gessner, Anjuli Szawiola
Publikováno v:
Chemistry & Biology. 20:1214-1224
Summary Streptomyces calvus is best known as the producer of the fluorinated natural product nucleocidin. This strain of Streptomycetes is also unusual for displaying a "bald" phenotype that is deficient in the formation of aerial mycelium and spores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b2954c3d90fc5cce7eb3dd3eb6573d
https://doi.org/10.1016/j.chembiol.2013.09.006
https://doi.org/10.1016/j.chembiol.2013.09.006
Autor:
Ricardo Medina, Peter Spanogiannopoulos, Andrew M. King, Gerard D. Wright, Wenliang Wang, Nicholas Waglechner, Maulik N. Thaker
Publikováno v:
Nature Biotechnology. 31:922-927
Microbially derived natural products are major sources of antibiotics and other medicines, but discovering new antibiotic scaffolds and increasing the chemical diversity of existing ones are formidable challenges. We have designed a screen to exploit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229474be99245a49020b2d5f203df34a
https://doi.org/10.1038/nbt.2685
https://doi.org/10.1038/nbt.2685
Autor:
Gerard D. Wright, Jonathan S O'Brien, Patricia L. Taylor, Irene Tang, Marie Yan, Arlene D. Sutherland, Lindsay Kalan, Wenliang Wang, Andrew C. Pawlowski, Mariya Morar, Maulik N. Thaker, Kirandeep Bhullar, Gianfranco De Pascale, Michael R. Mulvey, Marc J. Canova, Nicholas Waglechner, Fazmin Nizam, Marisa A. Azad, Andrew M. King, Kalinka Koteva, Linda Ejim, Peter Spanogiannopoulos, Andrew G. McArthur, Laura J. V. Piddock, Alison J. Baylay, Austin Yan, Tennison Yu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:3348-3357
The field of antibiotic drug discovery and the monitoring of new antibiotic resistance elements have yet to fully exploit the power of the genome revolution. Despite the fact that the first genomes sequenced of free living organisms were those of bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7596011fcff5e4c4b5b6a2d1f98b745
https://doi.org/10.1128/aac.00419-13
https://doi.org/10.1128/aac.00419-13
Autor:
Maulik N. Thaker, Gerard D. Wright
Publikováno v:
ACS Synthetic Biology
Synthetic biology offers a new path for the exploitation and improvement of natural products to address the growing crisis in antibiotic resistance. All antibiotics in clinical use are facing eventual obsolesce as a result of the evolution and dissem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4556dfc950efb245aef458a5d0fbfba6
https://doi.org/10.1021/sb300092n
https://doi.org/10.1021/sb300092n
Publikováno v:
ACS infectious diseases. 2(9)
Modification of natural product backbones is a proven strategy for the development of clinically useful antibiotics. Such modifications have traditionally been achieved through medicinal chemistry strategies or via in vitro enzymatic activities. In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9b4429dcd57f3ef7f15cdae86d6a6b
https://pubmed.ncbi.nlm.nih.gov/27759388
https://pubmed.ncbi.nlm.nih.gov/27759388
Autor:
Nancy L. McKenzie, Maulik N. Thaker, Justin R. Nodwell, Gerard D. Wright, Kalinka Koteva, Donald W. Hughes
Publikováno v:
The Journal of Antibiotics. 63:177-182
The bacterial genus Streptomyces is endowed with a remarkable secondary metabolism that generates an enormous number of bioactive small molecules. Many of these genetically encoded small molecules are used as antibiotics, anticancer agents and as oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95ba90c34aaae85d9273ed4a405edab
https://doi.org/10.1038/ja.2010.13
https://doi.org/10.1038/ja.2010.13
Autor:
Stefanie Hackl, Maulik N. Thaker, Grace Yim, Andreas Bechthold, Gerard D. Wright, Claudia Weber, David L. Zechel, Jörg Feldmann, Stephanie Vanner, Xi Ming Zhu, Lindsay Kalan, Alyssa Brewer, Dagmar S. Urgast, Anjuli Szawiola, Eva M. Krupp
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(17)
Nucleocidin is one of the very few natural products known to contain fluorine. Mysteriously, the nucleocidin producer Streptomyces calvus ATCC 13382 has not been observed to synthesize the compound since its discovery in 1956. Here, we report that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0417873bf3a0a633adaae5a2b71fa1d
https://pubmed.ncbi.nlm.nih.gov/26374477
https://pubmed.ncbi.nlm.nih.gov/26374477