Výsledky vyhledávání - "Maude Gerbaix"

Akademický článek

NADPH oxidase 4 deficiency attenuates experimental osteoarthritis in mice

Autor: Felix Renaudin, Didier Hannouche, Karim Oudina, Maude Gerbaix, Manon McGilligan Subilia, Joris Paccaud, Vincent Jaquet, Karl-Heinz Krause, Serge Ferrari, Thomas Laumonier

Publikováno v: RMD Open, Vol 9, Iss 1 (2023)

Objective Low-grade inflammation plays a pivotal role in osteoarthritis (OA) through exposure to reactive oxygen species (ROS). In chondrocytes, NADPH oxidase 4 (NOX4) is one of the major ROS producers. In this study, we evaluated the role of NOX4 on

Externí odkaz: https://doaj.org/article/c8cbeace34ae43b2ad0ce31e27257e90

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Akademický článek

Estrogen deficiency alters skeletal and metabolic responses to obesity and weight loss strategies

Autor: Maude Gerbaix, Maria Papageorgiou, Monique Etienne, Daniel Courteix, Julien Hermet, Christophe Montanier, Serge Ferrari, Lore Metz

Publikováno v: Bone Reports, Vol 13, Iss , Pp 100488- (2020)

Externí odkaz: https://doaj.org/article/77a6d35f327348afaeb46b19ab42f47e

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Akademický článek

Early sclerostin expression explains bone formation inhibition before arthritis onset in the rat adjuvant-induced arthritis model

Autor: Guillaume Courbon, Raphaëlle Lamarque, Maude Gerbaix, Robin Caire, Marie-Thérèse Linossier, Norbert Laroche, Mireille Thomas, Thierry Thomas, Laurence Vico, Hubert Marotte

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

Abstract Periarticular bone loss in rheumatoid arthritis (RA) is considered to be mainly related to synovial inflammation. However, strong bone loss has also described at the time of arthritis onset. Recently, a paradoxical exacerbation of joint dama

Externí odkaz: https://doaj.org/article/3324459e446043919c514f7d03b843cf

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Akademický článek

One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons

Autor: Maude Gerbaix, Vasily Gnyubkin, Delphine Farlay, Cécile Olivier, Patrick Ammann, Guillaume Courbon, Norbert Laroche, Rachel Genthial, Hélène Follet, Françoise Peyrin, Boris Shenkman, Guillemette Gauquelin-Koch, Laurence Vico

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract The weightless environment during spaceflight induces site-specific bone loss. The 30-day Bion-M1 mission offered a unique opportunity to characterize the skeletal changes after spaceflight and an 8-day recovery period in mature male C57/BL6

Externí odkaz: https://doaj.org/article/ca18ee232ea8420da5ef90bbd29606f1

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Akademický článek

Third harmonic generation imaging and analysis of the effect of low gravity on the lacuno-canalicular network of mouse bone.

Autor: Rachel Genthial, Maude Gerbaix, Delphine Farlay, Laurence Vico, Emmanuel Beaurepaire, Delphine Débarre, Aurélien Gourrier

Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0209079 (2019)

The lacuno-canalicular network (LCN) hosting the osteocytes in bone tissue represents a biological signature of the mechanotransduction activity in response to external biomechanical loading. Using third-harmonic generation (THG) microscopy with sub-

Externí odkaz: https://doaj.org/article/75dd509b79c34ff593774920b4bf6ec7

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Akademický článek

Eight Days of Earth Reambulation Worsen Bone Loss Induced by 1-Month Spaceflight in the Major Weight-Bearing Ankle Bones of Mature Mice

Autor: Maude Gerbaix, Heather White, Guillaume Courbon, Boris Shenkman, Guillemette Gauquelin-Koch, Laurence Vico

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Spaceflight induces bone alterations with site-specific rates of bone loss according to the weight-bearing function of the bone. For the first time, this study aimed to characterize bone microarchitecture and density alterations of three ankle bones

Externí odkaz: https://doaj.org/article/aeb60428726a4dbe8507337c2894053e

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Analysis of femurs from mice embarked on board BION‐M1 biosatellite reveals a decrease in immune cell development, including B cells, after 1 wk of recovery on Earth

Autor: Blandine Chazarin, Nassima Ouzren-Zarhloul, Maude Gerbaix, Georg Tascher, Fabrice Bertile, Pauline Maes, Stéphanie Ghislin, Evgenia Antropova, Jean-Pol Frippiat, Galina Vassilieva, Laurence Vico, Guillemette Gauquelin-Koch

Publikováno v: FASEB Journal
FASEB Journal, 2019, 33 (3), pp.3772-3783. ⟨10.1096/fj.201801463R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2019, 33 (3), pp.3772-3783. ⟨10.1096/fj.201801463R⟩

Bone loss and immune dysregulation are among the main adverse outcomes of spaceflight challenging astronauts' health and safety. However, consequences on B-cell development and responses are still under-investigated. To fill this gap, we used advance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a43b785ed33c872a80c4f7b07c9bfc
https://doi.org/10.1096/fj.201801463r

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Mechanically Driven Counter‐Regulation of Cortical Bone Formation in Response to Sclerostin‐Neutralizing Antibodies

Autor: Patrick Ammann, Serge Ferrari, Maude Gerbaix

Publikováno v: Journal of Bone and Mineral Research, Vol. 36, No 2 (2021) pp. 385-399

Sclerostin (Scl) antibodies (Scl-Ab) potently stimulate bone formation, but these effects are transient. Whether the rapid inhibition of Scl-Ab anabolic effects is due to a loss of bone cells' capacity to form new bone or to a mechanostatic downregul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea66cbfbc50569fa2eaaa5c3ee70b02
https://archive-ouverte.unige.ch/unige:153224

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