Design, synthesis, conformational analysis, and biological activity of Cα1-to-Cα6 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues

Autor: Francesca Nuti, Maud Larregola, Agnieszka Staśkiewicz, Bernhard Retzl, Nataša Tomašević, Lorenzo Macchia, Maria E. Street, Michał Jewgiński, Olivier Lequin, Rafal Latajka, Paolo Rovero, Christian W. Gruber, Michael Chorev, Anna Maria Papini

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Oxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. The biomedical use of OT peptides is limited amongst others by disadvantageous pharmacokinetic parameters. To increase the stability of OT

Externí odkaz: https://doaj.org/article/5e89b8ca7f1645cab06fcfd921debf44

Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor.

Autor: Arhamatoulaye Maïga, Jon Merlin, Elodie Marcon, Céline Rouget, Maud Larregola, Bernard Gilquin, Carole Fruchart-Gaillard, Evelyne Lajeunesse, Charles Marchetti, Alain Lorphelin, Laurent Bellanger, Roger J Summers, Dana S Hutchinson, Bronwyn A Evans, Denis Servent, Nicolas Gilles

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e68841 (2013)

ρ-Da1a is a three-finger fold toxin from green mamba venom that is highly selective for the α1A-adrenoceptor. This toxin has atypical pharmacological properties, including incomplete inhibition of (3)H-prazosin or (125)I-HEAT binding and insurmount

Externí odkaz: https://doaj.org/article/ea1b5de2a53b4c798bdec40a54b07f16

Epitope mapping of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in a mouse model of multiple sclerosis: microwave-assisted synthesis of the peptide antigens and ELISA screening

Autor: Giulia Pacini, Francesca Nuti, Matthaia Ieronymaki, Anna Maria Papini, Rina Aharoni, Paolo Rovero, Maud Larregola, Giuseppina Sabatino

Publikováno v: Journal of Peptide Science. 22:52-58

The role of pathologic auto-antibodies against myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis is a highly controversial matter. As the use of animal models may enable to unravel the molecular mechanisms of the human disorder, numerou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2075faa09d755d4c06ff1a7bf6fd559
https://doi.org/10.1002/psc.2839

Structure-Activity Relationship Studies, SPR Affinity Characterization, and Conformational Analysis of Peptides That Mimic the HNK-1 Carbohydrate Epitope

Autor: Feliciana Real-Fernández, Francesca Nuti, Diego Brancaccio, Maud Larregola, Alfonso Carotenuto, Paolo Rovero, Yihong Cao, Olivier Monasson, Anna Maria Papini, Ettore Novellino, Jacques Uziel, Matthaia Ieronymaki, Giuseppina Sabatino, Giada Rossi, Elisa Peroni

Publikováno v: ChemMedChem
12 (2017): 751–759. doi:10.1002/cmdc.201700042
info:cnr-pdr/source/autori:Ieronymaki, Matthaia; Nuti, Francesca; Brancaccio, Diego; Rossi, Giada; Real-Fernandez, Feliciana; Cao, Yihong; Monasson, Olivier; Larregola, Maud; Peroni, Elisa; Uziel, Jacques; Sabatino, Giuseppina; Novellino, Ettore; Carotenuto, Alfonso; Papini, Anna Maria; Rovero, Paolo/titolo:Structure-Activity Relationship Studies, SPR Affinity Characterization, and Conformational Analysis of Peptides That Mimic the HNK-1 Carbohydrate Epitope/doi:10.1002%2Fcmdc.201700042/rivista:ChemMedChem (Print)/anno:2017/pagina_da:751/pagina_a:759/intervallo_pagine:751–759/volume:12

The design of molecules that mimic biologically relevant glycans is a significant goal for understanding important biological processes and may lead to new therapeutic and diagnostic agents. In this study we focused our attention on the trisaccharide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ebeab6c83501002dfaa4faaf8a48d1
https://pubmed.ncbi.nlm.nih.gov/28403522

β-Amino acids containing peptides and click-cyclized peptide as β-turn mimics: a comparative study with ‘conventional’ lactam- and disulfide-bridged hexapeptides

Autor: Solange Lavielle, Maud Larregola, Philippe Karoyan, Olivier Lequin, Dominique Guianvarc'h

Publikováno v: Journal of Peptide Science. 17:632-643

The increasing interest in click chemistry and its use to stabilize turn structures led us to compare the propensity for β-turn stabilization of different analogs designed as mimics of the β-turn structure found in tendamistat. The β-turn conforma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef6e2fbeade6e8c1b6eebfce637665ec
https://doi.org/10.1002/psc.1382