Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Matyas Flemr"'
Autor:
Matyas Flemr, Marc Bühler
Publikováno v:
Cell Reports, Vol 12, Iss 4, Pp 709-716 (2015)
Induction of double-strand DNA breaks (DSBs) by engineered nucleases, such as CRISPR/Cas9 or transcription activator-like effector nucleases (TALENs), stimulates knockin of exogenous DNA fragments via homologous recombination (HR). However, the knock
Externí odkaz:
https://doaj.org/article/2de1e6b051464f57ad31bfd682964841
Autor:
Matyas Flemr, Michaela Schwaiger, Daniel Hess, Vytautas Iesmantavicius, Josip Ahel, Alex Charles Tuck, Fabio Mohn, Marc Buhler
Publikováno v:
RNA. :rna.079465.122
Removal of introns during pre-mRNA splicing, which is central to gene expression, initiates by base pairing of U1 snRNA with a 5' splice site (5'SS). In mammals, many introns contain weak 5'SSs that are not efficiently recognized by the canonical U1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3b18552a8c32546380d4084e20f622e
https://doi.org/10.1261/rna.079465.122
https://doi.org/10.1261/rna.079465.122
Autor:
Matyas Flemr, Michaela Schwaiger, Daniel Hess, Vytautas Iesmantavicius, Alex Charles Tuck, Fabio Mohn, Marc Bühler
Removal of introns during pre-mRNA splicing, which is central to gene expression, initiates by base pairing of U1 snRNA with a 5’ splice site (5’SS). In mammals, many introns contain weak 5’SSs that are not efficiently recognized by the canonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55e56c568d0d3d9d96a35bf71079a5eb
https://doi.org/10.1101/2022.01.25.477700
https://doi.org/10.1101/2022.01.25.477700
Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes
Autor:
Veronika Ostapcuk, Vytautas Iesmantavicius, Marc Bühler, Fabio Mohn, Nicolas H. Thomä, Aparna Pandey, Lisa Lampersberger, Anja Basters, Sarah H. Carl, Joerg Betschinger, Matyas Flemr, Daniel Hess
Publikováno v:
Nature. 557:739-743
De novo mutations in ADNP, which encodes activity-dependent neuroprotective protein (ADNP), have recently been found to underlie Helsmoortel–Van der Aa syndrome, a complex neurological developmental disorder that also affects several other organ fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13df1366c8ea78ffaf6bd154cfeb6bbe
https://doi.org/10.1038/s41586-018-0153-8
https://doi.org/10.1038/s41586-018-0153-8
Autor:
Alex Tuck, Thomas Welte, Marc Bühler, Philip Knuckles, Sarah H. Carl, Helge Großhans, Panagiotis Papasaikas, Matyas Flemr, Aneliya Rankova
Publikováno v:
Genesdevelopment. 33(17-18)
TRIM71/LIN-41, a phylogenetically conserved regulator of development, controls stem cell fates. Mammalian TRIM71 exhibits both RNA-binding and protein ubiquitylation activities, but the functional contribution of either activity and relevant primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28157cafd4380fda839388aebadc2b0d
https://pubmed.ncbi.nlm.nih.gov/31371437
https://pubmed.ncbi.nlm.nih.gov/31371437
Autor:
Filip Horvat, Michaela Vaskovicova, Josef Pasulka, Petr Svoboda, Matyas Flemr, Tomas Demeter, Eliska Svobodova, Radek Malik
Publikováno v:
Life Science Alliance
A systematic survey of dsRNA expression in mouse fibroblasts and embryonic stem cells shows main constraints for RNAi. RNAi activity depends on the initial Dicer cleavage of dsRNA, having implications for the evolution of mammalian RNAi functions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fafe5de371954fde983ce0dee7a548
https://doi.org/10.1101/485524
https://doi.org/10.1101/485524
Autor:
Alice Wenger, Marc Bühler, Fabio Mohn, Greggory M. Rice, Jason Borawski, Matyas Flemr, Alex Tuck, Razvan Nutiu, Kedar Nath Natarajan, Sarah A. Teichmann, Aneliya Rankova
Publikováno v:
Tuck, A C, Natarajan, K N, Rice, G M, Borawski, J, Mohn, F, Rankova, A, Flemr, M, Wenger, A, Nutiu, R, Teichmann, S & Bühler, M 2018, ' Distinctive features of lincRNA gene expression suggest widespread RNA-independent functions ', Life Science Alliance, vol. 1, no. 4, e201800124 . https://doi.org/10.26508/lsa.201800124
Life Science Alliance
Life Science Alliance
Combining single-cell RNA-seq of mouse ESCs and NPCs, lincRNA gene deletions, conditional RNA depletion, and nuclear exosome profiling distinguishes RNA-dependent and RNA-independent lincRNA gene activities.
Eukaryotic genomes produce RNAs lacki
Eukaryotic genomes produce RNAs lacki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063a917436f9dffa9ebe7d9750fe0325
https://findresearcher.sdu.dk:8443/ws/files/146232773/e201800124.full.pdf
https://findresearcher.sdu.dk:8443/ws/files/146232773/e201800124.full.pdf
dsRNA expression in the mouse elicits RNAi in oocytes and low adenosine deamination in somatic cells
Publikováno v:
Nucleic Acids Research
Double-stranded RNA (dsRNA) can enter different pathways in mammalian cells, including sequence-specific RNA interference (RNAi), sequence-independent interferon (IFN) response and editing by adenosine deaminases. To study the routing of dsRNA to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e0f63f53a26abc241b2404de0ad4a0
http://doc.rero.ch/record/299277/files/gkr702.pdf
http://doc.rero.ch/record/299277/files/gkr702.pdf
Autor:
Petr Svoboda, Matyas Flemr
Publikováno v:
Methods. 53:136-141
RNA molecules rarely function alone in cells. For most RNAs, their function requires formation of various ribonucleoprotein (RNP) complexes. For example, mRNP composition can determine mRNA localization, translational repression, level of translation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35619acae418f783989fde24f6b50048
https://doi.org/10.1016/j.ymeth.2010.08.005
https://doi.org/10.1016/j.ymeth.2010.08.005