Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment

Autor: Ruiz, L., Gurlo, T., Ravier, Ma, Anne Wojtusciszyn, Mathieu, J., Brown, MR, Broca, C., Bertrand, G., Butler, Pc, Matveyenko, Av, Dalle, S., Costes, S.

Publikováno v: Cell Death Discovery
Cell Death Discovery, Springer Nature, 2018, 9 (6), pp.600. ⟨10.1038/s41419-018-0603-0⟩
Cell death & disease, vol 9, iss 6
Cell Death & Disease
Cell Death Discovery, 2018, 9 (6), pp.600. ⟨10.1038/s41419-018-0603-0⟩
BASE-Bielefeld Academic Search Engine
Ruiz, L; Gurlo, T; Ravier, MA; Wojtusciszyn, A; Mathieu, J; Brown, MR; et al.(2018). Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. CELL DEATH & DISEASE, 9. doi: 10.1038/s41419-018-0603-0. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9894r9hv
Cell Death and Disease, Vol 9, Iss 6, Pp 1-12 (2018)
Cell Death Dis, vol. 9, no. 6, pp. 600

International audience; In type 2 diabetes, amyloid oligomers, chronic hyperglycemia, lipotoxicity, and pro-inflammatory cytokines are detrimental to beta-cells, causing apoptosis and impaired insulin secretion. The histone acetyl transferase p300, i

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