IL-22: Immunity's bittersweet symphony.

Autor: Duan J; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Matute JD; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Neonatology and Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Blumberg RS; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2023 Nov 06; Vol. 220 (11). Date of Electronic Publication: 2023 Sep 11.

Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut.

Autor: Duan J; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Matute JD; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Division of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Unger LW; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, and Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, CB2 0AW, UK; Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, 10090, Austria., Hanley T; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Schnell A; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA., Lin X; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Krupka N; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Griebel P; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Lambden C; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA., Sit B; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA., Grootjans J; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands., Pyzik M; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Sommer F; Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany., Kaiser S; Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany., Falk-Paulsen M; Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany., Grasberger H; Department of Internal Medicine, Division of Gastroenterology and Hepatology, Michigan Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Kao JY; Department of Internal Medicine, Division of Gastroenterology and Hepatology, Michigan Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Fuhrer T; Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland., Li H; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland., Paik D; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Lee Y; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Refetoff S; Department of Medicine, Pediatrics and Committee on Genetics, The University of Chicago, Chicago, IL 60637, USA., Glickman JN; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Paton AW; Research Centre for Infectious Diseases, Department of Molecular and Biomedical Science, the University of Adelaide, Adelaide, 5005, Australia., Bry L; Massachusetts Host-Microbiome Center, Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Paton JC; Research Centre for Infectious Diseases, Department of Molecular and Biomedical Science, the University of Adelaide, Adelaide, 5005, Australia., Sauer U; Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland., Macpherson AJ; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland., Rosenstiel P; Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany., Kuchroo VK; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA., Waldor MK; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA., Huh JR; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Kaser A; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, and Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, CB2 0AW, UK., Blumberg RS; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: rblumberg@bwh.harvard.edu.

Publikováno v: Immunity [Immunity] 2023 May 09; Vol. 56 (5), pp. 1115-1131.e9. Date of Electronic Publication: 2023 Mar 13.

Standardizing the Evaluation and Management of Necrotizing Enterocolitis in a Level IV NICU.

Autor: Aurora M; Divisions of aNewborn Medicine.; Departments of Pediatrics.; These authors contributed equally to this work., Keyes ML; Divisions of aNewborn Medicine.; Departments of Pediatrics.; Harvard Neonatal-Perinatal Medicine Fellowship Program, Boston, Massachusetts.; These authors contributed equally to this work., Acosta JG; Divisions of aNewborn Medicine.; Departments of Pediatrics., Swartz K; Divisions of aNewborn Medicine.; Departments of Pediatrics., Lombay J; Divisions of aNewborn Medicine.; Departments of Pediatrics., Ciaramitaro J; Pharmacy., Rudnick A; Divisions of aNewborn Medicine.; Departments of Pediatrics., Kelleher C; Pediatric Surgery., Hally S; Nursing., Gee M; Radiology, Massachusetts General Hospital, Boston, Massachusetts., Madhavan V; Infectious Disease.; Departments of Pediatrics., Roumiantsev S; Divisions of aNewborn Medicine.; Departments of Pediatrics., Cummings BM; Pediatric Intensive Care.; Departments of Pediatrics., Nelson BD; Divisions of aNewborn Medicine.; Departments of Pediatrics., Lerou PH; Divisions of aNewborn Medicine.; Departments of Pediatrics.; These authors co-supervised this work., Matute JD; Divisions of aNewborn Medicine.; Departments of Pediatrics.; These authors co-supervised this work.

Publikováno v: Pediatrics [Pediatrics] 2022 Oct 01; Vol. 150 (4).

Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation.

Autor: Mead BE; Harvard-MIT Program in Health Sciences and Technology, MIT, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.; Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Hattori K; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Levy L; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Imada S; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA., Goto N; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA., Vukovic M; Harvard-MIT Program in Health Sciences and Technology, MIT, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.; Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Division of Gastroenterology Boston Children's Hospital, Program in Immunology, Harvard Medical School, Boston, MA, USA., Sze D; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kummerlowe C; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Matute JD; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Neonatology, Department of Pediatrics, MGH Harvard Medical School, Boston, MA, USA., Duan J; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Langer R; Harvard-MIT Program in Health Sciences and Technology, MIT, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.; Department of Chemical Engineering, MIT, Cambridge, MA, USA., Blumberg RS; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ordovas-Montanes J; Harvard Stem Cell Institute, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Gastroenterology Boston Children's Hospital, Program in Immunology, Harvard Medical School, Boston, MA, USA., Yilmaz ÖH; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Department of Pathology, MGH, Harvard Medical School, Boston, MA, USA., Karp JM; Harvard-MIT Program in Health Sciences and Technology, MIT, Cambridge, MA, USA. jmkarp@bwh.harvard.edu.; Harvard Stem Cell Institute, Cambridge, MA, USA. jmkarp@bwh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. jmkarp@bwh.harvard.edu.; Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jmkarp@bwh.harvard.edu., Shalek AK; Harvard-MIT Program in Health Sciences and Technology, MIT, Cambridge, MA, USA. shalek@mit.edu.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA. shalek@mit.edu.; Harvard Stem Cell Institute, Cambridge, MA, USA. shalek@mit.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. shalek@mit.edu.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA. shalek@mit.edu.; Department of Chemistry, MIT, Cambridge, MA, USA. shalek@mit.edu.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. shalek@mit.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2022 Apr; Vol. 6 (4), pp. 476-494. Date of Electronic Publication: 2022 Mar 21.

The healing power of language: caring for patients with limited english proficiency and COVID-19.

Autor: Herzberg EM; Division of Neonatology and Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA., Barrero-Castillero A; Division of Neonatology and Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Division of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Matute JD; Division of Neonatology and Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA. jmatute@mgh.harvard.edu.

Publikováno v: Pediatric research [Pediatr Res] 2022 Feb; Vol. 91 (3), pp. 526-528. Date of Electronic Publication: 2021 Mar 31.