Zobrazeno 1 - 10
of 856
pro vyhledávání: '"Mature messenger RNA"'
Autor:
Andreas Kremling
Publikováno v:
Metabolic Engineering. 67:145-152
The allocation of resources during bacterial growth is strongly related to the availability of ribosomes and RNA polymerase molecules. Here, coarse-grained models offer a promising start due to their simple structure and the limited number of kinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2109ce3937447b130a395b1af4e556de
https://doi.org/10.1016/j.ymben.2021.06.006
https://doi.org/10.1016/j.ymben.2021.06.006
Autor:
Paul Kang, Bernice Fellows, Ajay A. Vashisht, William Martelly, James A. Wohlschlegel, Shalini Sharma
Publikováno v:
RNA Biol
During spliceosome assembly, interactions that bring the 5′ and 3′ ends of an intron in proximity are critical for the production of mature mRNA. Here, we report synergistic roles for the stem-loops 3 (SL3) and 4 (SL4) of the human U1 small nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb33b764bb0b6e52b375554551b7bf16
https://doi.org/10.1080/15476286.2021.1932360
https://doi.org/10.1080/15476286.2021.1932360
Autor:
Shihoko Kojima, Benjamin A Unruh
Publikováno v:
J Biol Rhythms
The identification and characterization of rhythmically expressed mRNAs have been an active area of research over the past 20 years, as these mRNAs are believed to produce the daily rhythms in a wide range of biological processes. Circadian transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aade86d7f3cf53d3398d7c70185b7e4d
https://doi.org/10.1177/0748730420957498
https://doi.org/10.1177/0748730420957498
Autor:
Sam-Yong Park, Kanako Kuwasako, Yutaka Muto, Takeshi Urano, Gyosuke Sakashita, Hisashi Yoshida, Eiji Obayashi, Yuko Nariai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
The accurate exclusion of introns by RNA splicing is critical for the production of mature mRNA. U2AF1 binds specifically to the 3´ splice site, which includes an essential AG dinucleotide. Even a single amino acid mutation of U2AF1 can cause seriou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc926103e39d6ef66fbd6a791cdf5e20
http://link.springer.com/article/10.1038/s41467-020-18559-6
http://link.springer.com/article/10.1038/s41467-020-18559-6
Autor:
Miroslaw Smietanski, Mateusz Fido, Victoria H. Cowling, Adam Mamot, Jacek Jemielity, Joanna Kowalska, Renata Kasprzyk, Przemyslaw Wanat, Michal Kopcial
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
In eukaryotes, mature mRNA is formed through modifications of precursor mRNA, one of which is 5' cap biosynthesis, involving RNA cap guanine-N7 methyltransferase (N7-MTase). N7-MTases are also encoded by some eukaryotic viruses and facilitate their r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ff6eb0421ccd225ae9c55682b4c5ff
https://doi.org/10.1002/chem.202001036
https://doi.org/10.1002/chem.202001036
Publikováno v:
Annual Review of Biochemistry
The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades of biochemistry and genetics combined with recent structural studies of the spliceosome have produced a detailed view of the mechanism of splicing. In this review, we a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d389e941a6e987844fe920f463879a0d
https://doi.org/10.1146/annurev-biochem-091719-064225
https://doi.org/10.1146/annurev-biochem-091719-064225
Autor:
Zhixing Cao, Ramon Grima
Publikováno v:
Cao, Z & Grima, R 2020, ' Analytical distributions for detailed models of stochastic gene expression in eukaryotic cells ', Proceedings of the National Academy of Sciences, vol. 117, no. 9, pp. 4682-4692 . https://doi.org/10.1073/pnas.1910888117
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance The random nature of gene expression is well established experimentally. Mathematical modeling provides a means of understanding the factors leading to the observed stochasticity. In this article, we extend the classical two-state model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741c3ab6f90ce511c6ca48a4f53eea2a
https://doi.org/10.1073/pnas.1910888117
https://doi.org/10.1073/pnas.1910888117
Autor:
Ramon Grima, Xiaoming Fu, Libin Xu, Heta P. Patel, Stefano Coppola, Zhixing Cao, Tineke L. Lenstra
Transcriptional rates are often estimated by fitting the distribution of mature mRNA numbers measured using smFISH (single molecule fluorescence in situ hybridization) with the distribution predicted by the telegraph model of gene expression, which d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da30784189df0392d0a446100f4fc4e7
https://doi.org/10.1101/2021.11.09.467882
https://doi.org/10.1101/2021.11.09.467882
Autor:
Rakesh N. Veedu, Akilandeswari Ashwini Balachandran, Suxiang Chen, Sarah D. Diermeier, Prithi Raguraman
Publikováno v:
Cancers
Cancers, Vol 13, Iss 5555, p 5555 (2021)
Cancers, Vol 13, Iss 5555, p 5555 (2021)
Simple Summary Splicing is an important mechanism by which precursor mRNA is modified into mature mRNA. This splicing plays a major role in the generation of different proteins required for cells. Cancer cells modulate this splicing in such a way tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15dfd48e24fccc1a723268279c4e438f
http://europepmc.org/articles/PMC8583451
http://europepmc.org/articles/PMC8583451
Publikováno v:
Braichenko, S, Holehouse, J & Grima, R 2021, ' Distinguishing between models of mammalian gene expression : Telegraph-like models versus mechanistic models ', Journal of The Royal Society Interface, vol. 18, no. 183 . https://doi.org/10.1098/rsif.2021.0510
Journal of the Royal Society Interface
Journal of the Royal Society Interface
Funding Information: S.B. and R.G. were supported by a Leverhulme Trust grant no. (RPG-2018-423). J.H. was supported by a BBSRC EASTBIO PhD studentship. Two-state models (telegraph-like models) have a successful history of predicting distributions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a9b6f1b9954dab140f4bcdb0339274
https://www.pure.ed.ac.uk/ws/files/235779750/rsif.2021.0510.pdf
https://www.pure.ed.ac.uk/ws/files/235779750/rsif.2021.0510.pdf