Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Mature Thymocyte"'
Autor:
Jacy Gameiro, Carolina Francelin, Ieda Geniseli, Liana Verinaud, Patrícia Resende Alo Nagib, Wilson Savino
Publikováno v:
Neuroimmunomodulation. 27:28-37
Background: Previous work revealed the existence of a severe thymic atrophy with massive loss of immature CD4+CD8+ thymocytes in animals developing insulin-dependent diabetes, chemically induced by alloxan. Furthermore, the intrathymic expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d415ae4892dc4452699b518f217978
https://doi.org/10.1159/000506054
https://doi.org/10.1159/000506054
Autor:
Vinicius Cotta-de-Almeida, Daniella Arêas Mendes-da-Cruz, Ailin Lepletier, Daiane Cristina F Golbert, Guilherme Loss, Marbella Maria Fonseca, Wilson Savino, Marcelo Ribeiro-Alves, Ana Tereza Ribeiro de Vasconcelos, Eliane Santana-Van-Vliet
Publikováno v:
Cell Adhesion & Migration. :1-16
The thymus supports differentiation of T cell precursors. This process requires relocation of developing thymocytes throughout multiple microenvironments of the organ, mainly with thymic epithelial cells (TEC), which control intrathymic T cell differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d480f8678fa099c077520ae025743d3
https://doi.org/10.1080/19336918.2017.1327513
https://doi.org/10.1080/19336918.2017.1327513
Autor:
Antal Rot, Robert J. B. Nibbs, Maria H. Ulvmar, William W. Agace, Graham Anderson, Katarzyna M. Sitnik, Andrea J. White, William E. Jenkinson, Beth Lucas
Publikováno v:
European Journal of Immunology. 45:574-583
Thymus colonisation and thymocyte positioning are regulated by interactions between CCR7 and CCR9, and their respective ligands, CCL19/CCL21 and CCL25. The ligands of CCR7 and CCR9 also interact with the atypical receptor CCRL1 (also known as ACKR4),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44df5ade855d5ead379b81f3d17219fe
https://doi.org/10.1002/eji.201445015
https://doi.org/10.1002/eji.201445015
Autor:
Johan Auwerx, Ying Cui, Ruth T. Yu, Ronald M. Evans, Jianrong Wang, Hui Xiao, Caroline Zhang, Shuo Zhang, Annette R. Atkins, Ye Zheng, Na Zhang, Ruihong Zhu, Nanhai He, Michael Downes, Dexian Quan, Christopher Liddle, Qibin Leng, Chunhui Yang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3242d1c20b7cc73aa028e8a5866a31
https://doi.org/10.1038/s41467-017-00931-8
https://doi.org/10.1038/s41467-017-00931-8
Autor:
Diana Varol, Steffen Jung, Zohar Barnett-Itzhaki, Tegest Aychek, Yifat Segal Hayoun, Ido Amit, Alexander Mildner, Nardi Lampl, Elik Chapnik, Natalia Rivkin, Eran Hornstein, Sigalit Boura-Halfon, Franziska Paul, Anita Bringmann
Publikováno v:
European journal of immunology. 47(7)
T-cell development is a spatially and temporally regulated process, orchestrated by well-defined contributions of transcription factors and cytokines. Here, we identify the noncoding RNA miR-142 as an additional regulatory layer within murine thymocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98fb7e9701fc676a53a00c3dac9109e
https://pubmed.ncbi.nlm.nih.gov/28471480
https://pubmed.ncbi.nlm.nih.gov/28471480
Publikováno v:
The Journal of Immunology. 188:2575-2582
We studied whether CD8 T cell responses that are mediated by unconventional MHC class Ib molecules are IL-15 dependent in mice. CD8+ T cell responses to Listeria monocytogenes infection that are restricted by the MHC class Ib molecule H2-M3 decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a791f62271809d1dda186002097b365b
https://doi.org/10.4049/jimmunol.1102393
https://doi.org/10.4049/jimmunol.1102393
Autor:
Duško Kosec, K. Radojević, Gordana Leposavić, Milica Perišić, Bosiljka Plećaš-Solarović, Vesna Pešić, Ivan Pilipović
Publikováno v:
International Immunopharmacology
Age-related increase in the density of thymic noradrenergic fibres and noradrenaline (NA) concentration is proposed to be associated with thymic involution and altered thymopoiesis. To test this hypothesis thymocyte differentiation/maturation and thy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc112e1830632ecda7186a0631e1e5f
https://doi.org/10.1016/j.intimp.2007.01.017
https://doi.org/10.1016/j.intimp.2007.01.017
Publikováno v:
Cell Death & Differentiation. 11:69-79
Cellular FLICE-inhibitory protein (c-FLIP) inhibits death receptor-mediated apoptosis by specific interaction with FADD and procaspase-8, and may thus interfere with activation events mediated by FADD and caspase-8. Recent studies, however, suggest t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1268255181affe566f72d36a34ecb30c
https://doi.org/10.1038/sj.cdd.4401316
https://doi.org/10.1038/sj.cdd.4401316
Autor:
Bruno Lucas, Claude Penit, Sandrine Léaument, Armelle Le Campion, Florence Vasseur, Nicole Dautigny
Publikováno v:
The Journal of Immunology. 168:1664-1671
In normal mice, single-positive thymocytes proliferate before being exported into the peripheral T cell pool. We measured the in vivo proliferation rates of mature thymocytes in several TCR transgenic mice. Different monoclonal TCR transgenic single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b922e30b9007d0a684f55c1cd4918f
https://doi.org/10.4049/jimmunol.168.4.1664
https://doi.org/10.4049/jimmunol.168.4.1664
Autor:
Lucile Miquerol, Sophie Ezine, Bernadette Nabarra, Axel Kahn, Florence Vasseur, Geoffroy de Ribains, Cécile Godard, Catherine Martinon
Publikováno v:
Clinical and Developmental Immunology, Vol 9, Iss 4, Pp 223-231 (2002)
Developmental Immunology
Developmental Immunology
Bone marrow progenitors migrate to the thymus, where they proliferate and differentiate into immunologically competent T cells. In this report we show that mice transgenic for SV40 T and t antigens under the control of the L-pyruvate kinase promoter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005fba59e426d6fac42bdfb623604e04
https://doaj.org/article/1ed030e85baa4a3c9bf058b48e3b7779
https://doaj.org/article/1ed030e85baa4a3c9bf058b48e3b7779