The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.

Autor: Baumgartner CK; AbbVie, North Chicago, IL, USA. christina.baumgartner@abbvie.com., Ebrahimi-Nik H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Ohio State University Comprehensive Cancer Center and Pelotonia Institute for Immuno-Oncology, Columbus, OH, USA., Iracheta-Vellve A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Pfizer, Groton, CT, USA., Hamel KM; AbbVie, North Chicago, IL, USA., Olander KE; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Davis TGR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., McGuire KA; AbbVie, North Chicago, IL, USA., Halvorsen GT; AbbVie, North Chicago, IL, USA., Avila OI; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Patel CH; Calico Life Sciences, South San Francisco, CA, USA., Kim SY; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Kammula AV; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Muscato AJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Halliwill K; AbbVie, South San Francisco, CA, USA., Geda P; AbbVie, North Chicago, IL, USA.; Bristol Myers Squibb, Summit, NJ, USA., Klinge KL; AbbVie, North Chicago, IL, USA., Xiong Z; AbbVie, North Chicago, IL, USA.; Ipsen Biosciences, Cambridge, MA, USA., Duggan R; AbbVie, North Chicago, IL, USA., Mu L; AbbVie, North Chicago, IL, USA., Yeary MD; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Patti JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Balon TM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Mathew R; AbbVie, South San Francisco, CA, USA., Backus C; AbbVie, South San Francisco, CA, USA., Kennedy DE; AbbVie, North Chicago, IL, USA., Chen A; AbbVie, North Chicago, IL, USA., Longenecker K; AbbVie, North Chicago, IL, USA., Klahn JT; AbbVie, North Chicago, IL, USA., Hrusch CL; AbbVie, North Chicago, IL, USA., Krishnan N; AbbVie, North Chicago, IL, USA.; Monte Rosa Therapeutics, Boston, MA, USA., Hutchins CW; AbbVie, North Chicago, IL, USA., Dunning JP; AbbVie, North Chicago, IL, USA., Bulic M; AbbVie, North Chicago, IL, USA., Tiwari P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Colvin KJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Chuong CL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Kohnle IC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Boghossian A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ronan M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wu MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Suermondt JSMT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Knudsen NH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Cheruiyot CK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Sen DR; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Griffin GK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Golub TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., El-Bardeesy N; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Decker JH; AbbVie, North Chicago, IL, USA., Yang Y; AbbVie, North Chicago, IL, USA., Guffroy M; AbbVie, North Chicago, IL, USA., Fossey S; AbbVie, North Chicago, IL, USA., Trusk P; AbbVie, North Chicago, IL, USA., Sun IM; Calico Life Sciences, South San Francisco, CA, USA., Liu Y; Calico Life Sciences, South San Francisco, CA, USA., Qiu W; AbbVie, North Chicago, IL, USA., Sun Q; AbbVie, North Chicago, IL, USA., Paddock MN; Calico Life Sciences, South San Francisco, CA, USA., Farney EP; AbbVie, North Chicago, IL, USA., Matulenko MA; AbbVie, North Chicago, IL, USA., Beauregard C; Calico Life Sciences, South San Francisco, CA, USA.; Vir Biotechnology, San Francisco, CA, USA., Frost JM; AbbVie, North Chicago, IL, USA. jennifer.frost@abbvie.com., Yates KB; Broad Institute of MIT and Harvard, Cambridge, MA, USA. yates@broadinstitute.org.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. yates@broadinstitute.org., Kym PR; AbbVie, North Chicago, IL, USA. phil.r.kym@abbvie.com., Manguso RT; Broad Institute of MIT and Harvard, Cambridge, MA, USA. rmanguso@mgh.harvard.edu.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. rmanguso@mgh.harvard.edu.

Publikováno v: Nature [Nature] 2023 Oct; Vol. 622 (7984), pp. 850-862. Date of Electronic Publication: 2023 Oct 04.

Scalable Asymmetric Syntheses of Foslevodopa and Foscarbidopa Drug Substances for the Treatment of Parkinson's Disease.

Autor: Huters AD, Stambuli J, Klix RC, Matulenko MA, Chan VS, Simanis J, Hill DR, Reddy RE, Towne TB, Bellettini JR, Kotecki BJ, Cardinal-David B, Ji J, Voight EA, Shou M, Balaraman S; Anthem Biosciences, No. 49 Canara Bank Road, Bommasandra Industrial Area, Bangalore 560 099, Karnataka, India., Ashok A; Anthem Biosciences, No. 49 Canara Bank Road, Bommasandra Industrial Area, Bangalore 560 099, Karnataka, India., Ghosh S; Anthem Biosciences, No. 49 Canara Bank Road, Bommasandra Industrial Area, Bangalore 560 099, Karnataka, India.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2022 Feb 18; Vol. 87 (4), pp. 1986-1995. Date of Electronic Publication: 2021 Jul 19.

Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).

Autor: Wagner R; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Randolph JT; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Patel SV; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Nelson L; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Matulenko MA; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Keddy R; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Pratt JK; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Liu D; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Krueger AC; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Donner PL; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Hutchinson DK; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Flentge C; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Betebenner D; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Rockway T; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Maring CJ; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Ng TI; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Krishnan P; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Pilot-Matias T; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Collins C; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Panchal N; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Reisch T; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Dekhtyar T; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Mondal R; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Stolarik DF; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Gao Y; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Gao W; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Beno DA; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Kati WM; Global Pharmaceutical Research and Development , AbbVie , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 May 10; Vol. 61 (9), pp. 4052-4066. Date of Electronic Publication: 2018 Apr 23.

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