Cryptosporidium life cycle small molecule probing implicates translational repression and an Apetala 2 transcription factor in macrogamont differentiation.

Autor: Hasan, Muhammad M.^1,2 (AUTHOR), Mattice, Ethan B.^1,2 (AUTHOR), Teixeira, José E.¹ (AUTHOR), Jumani, Rajiv S.^1,2 (AUTHOR), Stebbins, Erin E.¹ (AUTHOR), Klopfer, Connor E.¹ (AUTHOR), Franco, Sebastian E.¹ (AUTHOR), Love, Melissa S.³ (AUTHOR), McNamara, Case W.³ (AUTHOR), Huston, Christopher D.^1,2 (AUTHOR) christopher.huston@uvm.edu

Publikováno v: PLoS Pathogens. 4/26/2024, Vol. 20 Issue 4, p1-24. 24p.

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Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice.

Autor: Ajiboye J; Department of Medicine, University of Vermont Larner College of Medicine, Room 202 Stafford Hall, 95 Carrigan Drive, Burlington, Vermont, USA., Teixeira JE; Department of Medicine, University of Vermont Larner College of Medicine, Room 202 Stafford Hall, 95 Carrigan Drive, Burlington, Vermont, USA., Gasonoo M; Department of Chemistry, Saint Louis University, Room 206 Monsanto Hall, 3501 Laclede Avenue, Saint Louis, MO, USA., Mattice EB; Department of Medicine, University of Vermont Larner College of Medicine, Room 202 Stafford Hall, 95 Carrigan Drive, Burlington, Vermont, USA., Korwin-Mihavics B; Department of Medicine, University of Vermont Larner College of Medicine, Room 202 Stafford Hall, 95 Carrigan Drive, Burlington, Vermont, USA., Miller P; Department of Medicine, University of Vermont Larner College of Medicine, Room 202 Stafford Hall, 95 Carrigan Drive, Burlington, Vermont, USA., Cameron AC; Department of Medicine, University of Vermont Larner College of Medicine, Room 202 Stafford Hall, 95 Carrigan Drive, Burlington, Vermont, USA., Stebbins E; Department of Medicine, University of Vermont Larner College of Medicine, Room 202 Stafford Hall, 95 Carrigan Drive, Burlington, Vermont, USA., Campbell SD; Department of Molecular Microbiology and Immunology, Saint Louis University, Room 316 Doisy Research Center, 1100 South Grand Boulevard, Saint Louis, MO, USA., Griggs DW; Department of Molecular Microbiology and Immunology, Saint Louis University, Room 316 Doisy Research Center, 1100 South Grand Boulevard, Saint Louis, MO, USA., Spangenberg T; Global Health R&D of Merck Healthcare, Ares Trading S.A. (a subsidiary of Merck KGaA, Darmstadt, Germany), Route de Crassier 1, Eysins, Switzerland., Meyers MJ; Department of Chemistry, Saint Louis University, Room 206 Monsanto Hall, 3501 Laclede Avenue, Saint Louis, MO, USA. marvin.j.meyers@slu.edu., Huston CD; Department of Medicine, University of Vermont Larner College of Medicine, Room 202 Stafford Hall, 95 Carrigan Drive, Burlington, Vermont, USA. christopher.huston@uvm.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8272. Date of Electronic Publication: 2024 Sep 27.